全文获取类型
收费全文 | 650篇 |
免费 | 34篇 |
国内免费 | 1篇 |
出版年
2022年 | 5篇 |
2021年 | 28篇 |
2020年 | 18篇 |
2019年 | 3篇 |
2018年 | 7篇 |
2017年 | 7篇 |
2016年 | 7篇 |
2015年 | 14篇 |
2014年 | 18篇 |
2013年 | 36篇 |
2012年 | 42篇 |
2011年 | 38篇 |
2010年 | 26篇 |
2009年 | 25篇 |
2008年 | 37篇 |
2007年 | 33篇 |
2006年 | 27篇 |
2005年 | 25篇 |
2004年 | 22篇 |
2003年 | 20篇 |
2002年 | 10篇 |
2001年 | 17篇 |
2000年 | 17篇 |
1999年 | 19篇 |
1998年 | 7篇 |
1997年 | 17篇 |
1996年 | 4篇 |
1995年 | 7篇 |
1994年 | 8篇 |
1993年 | 3篇 |
1992年 | 10篇 |
1991年 | 5篇 |
1990年 | 7篇 |
1989年 | 6篇 |
1988年 | 4篇 |
1987年 | 10篇 |
1986年 | 10篇 |
1985年 | 6篇 |
1984年 | 5篇 |
1983年 | 7篇 |
1982年 | 9篇 |
1981年 | 4篇 |
1980年 | 8篇 |
1979年 | 11篇 |
1978年 | 9篇 |
1976年 | 3篇 |
1972年 | 6篇 |
1966年 | 2篇 |
1965年 | 3篇 |
1963年 | 3篇 |
排序方式: 共有685条查询结果,搜索用时 140 毫秒
21.
Jayaraman Selvaraj Veeraraghavan Vishnupriya Hussain Sardar Janardhana Papayya Balakrishna Josephine Rex Surapaneni Krishna Mohan Periyasamy Vijayalakshmi Rajagopal Ponnulakshmi 《Bioinformation》2020,16(11):801
Beta-catenin is linked with colorectal cancer (CRC). Therefore, it is of interest to design and develop novel compounds to combat CRC. Hence, we document compounds (chlorogenic acid, gallic acid, protocatechuic acid, quercetin and vanillic acid) from Lycopersicon esculentum with optimal binding features for further consideration. 相似文献
22.
Sarkar Monaj Kumar Kar Amrita Jayaraman Adithyan Shanmugam Karthi Vadivel Vellingiri Mahapatra Santanu Kar 《Molecular biology reports》2021,48(6):5327-5334
Molecular Biology Reports - Myricitrin, a naturally occurring flavonoid in Madhuca longifolia, possesses several medicinal properties. Even though our earlier work revealed its role against the... 相似文献
23.
Gayatri Jayaraman Karikalan Sinha Subodh Kumar Roy Pranita Mandal Pranab Kumar 《Plant Molecular Biology Reporter》2021,39(3):520-545
Plant Molecular Biology Reporter - Polyploidization plays an important role in the genesis of cultivated wheat (hexaploid and tetraploid) from its diploid progenitors. Thus, evolution during... 相似文献
24.
25.
Lavanya Prathap Selvaraj Jayaraman Anitha Roy Preetha Santhakumar M Jeevitha 《Bioinformation》2021,17(2):363
Inflammation is a process triggered by pro-inflammatory cytokines and anti-inflammatory molecules. Therefore, it is of interest to document the anti-inflammatory activity of Stachydrine and Sakuranetin against the inflammatory target proteins IL-6 and TNF-α by using molecular docking analysis. Both compounds showed good binding features with the selected target proteins. Compared to Sakuranetin, the Stachydrine have low binding energy and good hydrogen bond interactions. Hence, data show that Stachydrine possessed high and specific inhibitory activity on tumor necrosis factor-α and interleukin-6. 相似文献
26.
BS Sabna Thankappan Bency Mahendran Ramasamy Muthusamy Gayathri Femil selta Daniel Raja Angayarkanni Jayaraman 《Probiotics and antimicrobial proteins》2021,13(4):993-1004
Probiotics and Antimicrobial Proteins - Gamma-aminobutyric acid (GABA) is a principal inhibitory neurotransmitter in the central nervous system and is produced by irreversible decarboxylation of... 相似文献
27.
The signal produced by fluorescence in situ hybridization (FISH) often is inconsistent among cells and sensitivity is low. Small DNA targets on the chromatin are difficult to detect. We report here an improved nick translation procedure for Texas red and Alexa Fluor 488 direct labeling of FISH probes. Brighter probes can be obtained by adding excess DNA polymerase I. Using such probes, a 30?kb yeast transgene, and the rp1, rp3 and zein multigene clusters were clearly detected. 相似文献
28.
Huynh Vu Pradeep Singh Laurie Lewis Joseph G. Zendegui Krishna Jayaraman 《Nucleosides, nucleotides & nucleic acids》2013,32(8):853-864
Abstract DMT-Cholesteryl succinylamino solid supports (CPG, loading: 33 μmole/gram and TentaGel loading: 152 μmole/gram) and DMT-cholesteryl phosphoramidite were prepared for use in automated DNA synthesis of cholesteryl modified TFOs in the synthesis scales from 0.2 to 300 μmole. The modified TFOs were found to have a 5 to 50 fold increase in their uptake properties. 相似文献
29.
Annan Sudarsan Arun Kumar Gurusamy Umamaheswaran Ramamoorthy Padmapriya Jayaraman Balachandar Chandrasekaran Adithan 《Molecular biology reports》2013,40(2):1275-1281
Myocardial infarction (MI) is a complex multi-factorial, polygenic disorder which results from an interaction between a person’s genetic makeup and various environmental factors. Nitric oxide (NO), a potent vasodilator produced by endothelial cells, plays an important role in the regulation of blood pressure, regional blood flow and also inhibits platelet aggregation, vascular smooth muscle cell proliferation and leukocyte adhesion to vascular endothelium. Our aim was to analyze the association of NOS3 (endothelial nitric oxide synthase 3) 894G>T and ?786T>C gene polymorphisms and MI risk in the South Indian population. A total of 287 MI patients, 279 risk control patients and 321 healthy controls were recruited for the retrospective study. Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). There was no significant association observed between NOS3 894G>T, ?786T>C polymorphisms and MI. A significant difference was observed in the distribution of GT genotype of the NOS3 894G>T polymorphism between the cases and the risk controls (p = 0.05) but the odds ratio (0.6) did not show risk for MI. The present study showed lack of association between NOS3 gene polymorphisms and MI in South Indian population. 相似文献
30.
Uxmal and Tulum are two important Mayan sites in the Yucatan peninsula. The buildings are mainly composed of limestone and grey/black discoloration is seen on exposed walls and copious greenish biofilms on inner walls. The principal microorganisms detected on interior walls at both Uxmal and Tulum were cyanobacteria; heterotrophic bacteria and filamentous fungi were also present. A dark‐pigmented mitosporic fungus and Bacillus cereus, both isolated from Uxmal, were shown to be acidogenic in laboratory cultures. Cyanobacteria belonging to rock‐degrading genera Synechocystis and Gloeocapsa were identified at both sites. Surface analysis previously showed that calcium ions were present in the biofilms on buildings at Uxmal and Tulum, suggesting the deposition of biosolubilized stone. Apart from their potential to degrade the substrate, the coccoid cyanobacteria supply organic nutrients for bacteria and fungi, which can produce organic acids, further increasing stone degradation. 相似文献