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371.
Farid Kazemi Mazyar Azar Foad Kazemi Tahereh Hadisinia Javad Teymori Ghazale Geraily 《Reports of Practical Oncology and Radiotherapy》2021,26(6):915
BackgroundStereotactic radiosurgery (SRS) method has been considered the first-line treatment option to treat patients involved with pre-optic nerve tumors. However, studies have shown that using fractionated SRS, normal tissue sparing and tumor dose can be strongly increased simultaneously. Our main goal was to illustrate the effects of fractionated SRS approach in optic nerve tumor treatment and its adjacent sensitive structures.Materials and methods19 patients involved in optic nerve tumor with clinical symptoms of vision loss were treated with Gamma Knife radiosurgery in three sessions with 12 hours intervals between them. The prescribed dose was about 6.0 ± 1.2 Gy. Patient-related parameters including pre-treatment and after-treatment tumor size, visual acuity and visual field were evaluated using the Snell chart and MRI imaging. Patients were followed for about 14 months.ResultThe overall result showed vision improvement for patients with low and moderate visual loss. However, there was no significant improvement in patients with severe visual loss. Relative improvement was observed in blind patients, although poorly. There was no evidence of growth, recurrence, or new tumor after treatment in patients.ConclusionFractionated gamma knife radiosurgery offers a safe and effective alternative for benign lesions adjacent to the optic nerve. 相似文献
372.
Zahereh Karimi Javad Daneshmoghadam Hamid Ghaedi Ehsan Khalili Ghodratollah Panahi Mehrnoosh Shanaki 《Reports of Biochemistry & Molecular Biology》2022,10(4):580
Background:Genome-wide association studies (GWAS) have been the primary tool for an unbiased study of the genetic background of coronary artery disease (CAD). They have identified a list of single-nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD). In this study, we aimed to replicate the association of rs2954029 and rs6982502, a GWAS identified SNP, to CAD in an Iranian population.Methods:A sample of 285 subjects undergoing coronary angiography, including 134 CAD patients and 151 healthy. The genotype determination of rs2954029 and rs6982502 SNPs performed using the high-resolution melting analysis (HRM) technique.Results:Our results revealed that the TT genotype of rs2954029 (p= 0.009) and rs6982502 (p< 0.001) were significantly higher in CAD patients compared with controls. Binary logistic regression showed that rs6982502 and rs2954029 increase the risk of CAD incidence (2.470 times, p= 0.011, 95% CI= [1.219-4.751], and 2.174 times, p= 0.033, 95% CI= [1.066-4.433] respectively). After adjusting for confounders, we found that rs6982502 and rs2954029 are significantly associated with CAD risk.Conclusion:These data showed that the TT genotype of rs2954029 and rs6982502 is associated with the risk of CAD in a hospital-based sample of the Iranian population, which has replicated the result of recent GWAS studies.Key Words: Coronary Artery Disease (CAD), Genome-Wide Association Studies (GWAS), High-Resolution Melting (HRM), Single-Nucleotide Polymorphisms (SNP) 相似文献
373.
Hadi?Pirasteh-AnoshehEmail authorView authors OrcID profile Yahya?Emam Mohammad?Javad?Rousta Muhammad?Ashraf 《Journal of Plant Growth Regulation》2017,36(1):227-239
In this research, the effect of different SA concentrations (0, 0.5, 1.0, 1.5, and 2.0 mM) on biological and grain yield as well as Na+, K+, Cl?, Ca2+, and Mg2+ distribution and accumulation in barley plants was examined under nonsaline (2 dS m?1) and saline (12 dS m?1) conditions in a three-year field study (2012–2015 growing seasons). Storage factor (SF) was defined as the concentration of an ion in the root, as a proportion of total uptake of that ion, to quantify ion partitioning between root and shoot. Salt stress decreased SF for K+, Ca2+, and Mg2+ and enhanced it for Na+ and Cl?, which led to reduce grain and biological yield. Nonetheless, foliar-applied SA in varying concentrations could lower some of these adverse effects on ion transport and accumulation. At the 2nd and 3rd years, unfavorable climatic conditions such as less precipitation and higher temperature intensified salt stress and decreased the alleviating impact of SA. Foliar application of SA at higher levels increased SF for Na+ and Cl? ions and decreased that for K+ indicating that SA helped barley plants keep more Na+ and Cl? and less K+ ions in the root system, which suggested the probable role of SA in altering ion transport within the plant in favor of salt stress tolerance. SF was found to be more correlated with grain yield under both nonsaline and saline conditions. Overall, SF might be considered as a potential criterion for salt tolerance in barley plants. 相似文献
374.
A novel recombinant anti‐epidermal growth factor receptor peptide vaccine capable of active immunization and reduction of tumor volume in a mouse model
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Majid Asadi‐Ghalehni Mohamad Javad Rasaee Masoumeh RajabiBazl Masood Khosravani Majid Motaghinejad Masoud Javanmardi Saeed Khalili Helmout Modjtahedi Esmaeil Sadroddiny 《Microbiology and immunology》2017,61(12):531-538
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Somayeh Igder Javad Mohammadiasl Shima Azadpour Esrafil Mansouri Hassan Ashktorab Pooneh Mokarram 《Journal of cellular biochemistry》2020,121(4):2901-2908
Colorectal cancer (CRC), regardless of standard procedures of treatment and screening, is still considered one of the deadliest cancers in the Western world, and in economically developed Asian countries, especially Iran. The current study was undertaken to investigate whether changes in the level of Cripto-1 (CR-1) expression and KRAS mutations have a cumulative effect on the onset and progression of CRC. Fifty colorectal tissue samples, including 35 colorectal carcinomas with matching adjacent mucosa, and 15 colorectal adenomas, were chosen for analysis. Twenty-five CRC biopsies and 15 adenoma were analyzed for KRAS mutations by DNA sequencing (Sanger sequencing), and all 50 patients (35 CRCs and 15 adenomas) were evaluated by immunohistochemistry for the CR-1 protein expression. The inducible somatic KRAS mutation (G12D) was observed in nine (36%) of CRC patients, and in two (13.3%) of adenoma patients. The CR-1 expression level in both adenomas (P < .05) and carcinomas (P < .001), were significantly different, compared with the matching adjacent mucosa. The intensity of CR-1 staining in adenomas was less than the intensity of staining, detected in the CRCs (P < .001). The G12D KRAS mutation and CR-1 abnormalities are significantly associated as two signature biomarkers with potential clinical characteristics for the detection of CRC development. 相似文献
377.
Mehrnaz Ghafari Fateme Haghiralsadat Soudeh Khanamani Falahati-pour Javad Zavar Reza 《Journal of cellular biochemistry》2020,121(7):3584-3592
Cisplatin is one of the conventional drugs used in chemotherapy which has a potent antitumor function. However, due to the dangerous side effects, including the damage to DNA of the normal cells, its clinical use is limited. The aim of this study was to prepare and characterize nanoliposome containing cisplatin. We optimized liposome formulations through the modification of the proportion of SPC80 (soybeanphospholipids with 75% phosphatidylcholine) and cholesterol content. Then, novel PEGylated liposomal formulations containing SPC80: cholesterol: DSPE-mPEG (at ratios of 85:10:5) were designed and developed to serve as a therapy to achieve more improved pharmaceutical efficiency. Zeta Sizer showed that PEGylated nanoliposomes had a mean diameter of 119.7 ± 2.1 nm, a zeta potential of −26.03 ± 1.34 mV, and entrapment efficiency of 96.65 ± 3%. The optimum formulations represented sustained, thermo-sensitive release, and augmented cellular uptake. The cytotoxic effect of the liposomal drug was higher than the free medication drug that confirmed the efficiency of cellular uptake. This study suggests that nanoliposome-loaded cisplatin plays a vital role in improving drug efficacy and the reduction of dosage. 相似文献
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379.
Kandi Mohammad Reza Mohammadnejad Javad Shafiee Ardestani Mehdi Zabihollahi Rezvan Soleymani Sepehr Aghasadeghi Mohammad Reza Baesi Kazem 《Molecular biology reports》2019,46(1):143-149
Molecular Biology Reports - The development of new combinations to empower better protection against HIV infection is particularly important. Anionic polymers can block HIV infection. In the... 相似文献
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