Molecular and histopathological profiling of imiquimod induced dermatosis in Swiss Wistar rats: contribution to the rat model for novel anti-psoriasis treatments

Molecular Biology Reports - Imiquimod (IMQ) induced human-like psoriasis in mice has been shown to be effective in testing and development of novel treatments. The IMQ psoriasis model has become...     

Sesquiterpenes from Kleinia species

The investigation of four Kleinia species afforded, in addition to known compounds, seven new germacrane and three oplopane derivatives, all highly oxygenated. This kind of sesquiterpene seems to be characteristic of the genus Kleinia and related succulent species, and its tentative grouping is discussed.     

Reproductive traits and population dynamics of benthic invertebrates indicate episodic recruitment patterns across an Arctic polar front

Climate‐induced changes in the ocean and sea ice environment of the Arctic are beginning to generate major and rapid changes in Arctic ecosystems, but the effects of directional forcing on the persistence and distribution of species remain poorly understood. Here, we examine the reproductive traits and population dynamics of the bivalve Astarte crenata and sea star Ctenodiscus crispatus across a north–south transect that intersects the polar front in the Barents Sea. Both species present large oocytes indicative of short pelagic or direct development that do not differ in size–frequency between 74.5 and 81.3º latitude. However, despite gametogenic maturity, we found low frequencies of certain size classes within populations that may indicate periodic recruitment failure. We suggest that recruitment of A. crenata could occur periodically when conditions are favorable, while populations of C. crispatus are characterized by episodic recruitment failures. Pyloric caeca indices in C. crispatus show that food uptake is greatest at, and north of, the polar front, providing credence to the view that interannual variations in the quantity and quality of primary production and its flux to the seafloor, linked to the variable extent and thickness of sea ice, are likely to be strong determinants of physiological fitness. Our findings provide evidence that the distribution and long‐term survival of species is not only a simple function of adaptive capacity to specific environmental changes, but will also be contingent on the frequency and occurrence of years where environmental conditions support reproduction and settlement.     

Further eudesmanolides and xanthanolides from Telekia speciosa

The re-investigation of the aerial parts of Telekia speciosa afforded five new sesquiterpene lactones, two eudesmanolides and three xanthanolides, all closely related to those isolated before from this species or from related genera. The structures were elucidated by ¹H NMR spectroscopy.     

Derivation and analysis of new stand-level mortality models based on existing growth equations

Considering that, the temporal trend in stocking, expressed as number of trees per unit area, is the opposite of that of growth, and that both trajectories are sigmoidal, we derived a temporal trajectory of density decrease by reversing the temporal trend of a generalized growth function. We derived and analysed twelve stand-level mortality models by using four data sets from monospecific even-aged stands. Stand dominant height rather than stand age was incorporated as an indicator of the growth stage and a careful examination of the models conformity with the essential logical properties of the stand-level survival models was conducted. We first tested the models adequacy and general predictive performance by fitting them to parameterization data sets and subsequently assessing them with validation data. The regression equations were re-fitted afterwards over the total data sets to make use of all available information in the final parameter estimates. Nine model formulations were successfully fitted and four of them were the most adequate in describing stand density decrease with dominant height growth. The site-specific effect was incorporated in the newly derived models through the predictor variable and the stand-specific starting density was accounted for through a specific model parameter. These new dominant height-dependent mortality equations can be considered for inclusion in the framework of stand-level growth models as transition functions.