全文获取类型
收费全文 | 1280篇 |
免费 | 53篇 |
国内免费 | 1篇 |
出版年
2021年 | 22篇 |
2020年 | 16篇 |
2019年 | 14篇 |
2018年 | 32篇 |
2017年 | 21篇 |
2016年 | 34篇 |
2015年 | 45篇 |
2014年 | 51篇 |
2013年 | 103篇 |
2012年 | 77篇 |
2011年 | 90篇 |
2010年 | 57篇 |
2009年 | 48篇 |
2008年 | 61篇 |
2007年 | 60篇 |
2006年 | 84篇 |
2005年 | 58篇 |
2004年 | 40篇 |
2003年 | 43篇 |
2002年 | 31篇 |
2001年 | 20篇 |
2000年 | 9篇 |
1999年 | 13篇 |
1998年 | 9篇 |
1997年 | 6篇 |
1996年 | 10篇 |
1995年 | 16篇 |
1994年 | 11篇 |
1993年 | 8篇 |
1992年 | 16篇 |
1991年 | 6篇 |
1989年 | 8篇 |
1988年 | 6篇 |
1985年 | 9篇 |
1984年 | 8篇 |
1982年 | 10篇 |
1981年 | 7篇 |
1979年 | 6篇 |
1978年 | 6篇 |
1976年 | 6篇 |
1975年 | 7篇 |
1967年 | 7篇 |
1961年 | 7篇 |
1959年 | 5篇 |
1958年 | 5篇 |
1957年 | 8篇 |
1956年 | 7篇 |
1928年 | 5篇 |
1927年 | 8篇 |
1917年 | 5篇 |
排序方式: 共有1334条查询结果,搜索用时 578 毫秒
991.
Durovska J Bazovska S Pancak J Zaborska M Derdakova M Traubner P 《Neuro endocrinology letters》2011,32(4):411-414
The work describes three cases of patients at various ages, diagnosed for CNS demyelinating disease. The presence of specific antibodies to B. burgdorferi sensu lato, and findings of B. burgdorferi s.l. DNA, identified in one case as the genospecies B. garinii in the liquor, indicated previous experience with the infection. Presumably, persistence of borrelia in the organism could act as one of the autoimmune process triggers, resulting in the demyelinating disease. 相似文献
992.
Stiborova M Mares J Levova K Pavlickova J Barta F Hodek P Frei E Schmeiser HH 《Neuro endocrinology letters》2011,32(Z1):121-130
993.
994.
Snajdr J Cajthaml T Valášková V Merhautová V Petránková M Spetz P Leppänen K Baldrian P 《FEMS microbiology ecology》2011,75(2):291-303
The links among the changes in litter chemistry, the activity of extracellular enzymes and the microbial community composition were observed in Quercus petraea litter. Three phases of decomposition could be distinguished. In the early 4-month stage, with high activities of β-glucosidase, β-xylosidase and cellobiohydrolase, 16.4% of litter was decomposed. Hemicelluloses were rapidly removed while cellulose and lignin degradation was slow. In months 4-12, with high endocellulase and endoxylanase activities, decomposition of cellulose prevailed and 31.8% of litter mass was lost. After the third phase of decomposition until month 24 with high activity of ligninolytic enzymes, the litter mass loss reached 67.9%. After 2 years of decay, cellulose decomposition was almost complete and most of the remaining polysaccharides were in the form of hemicelluloses. Fungi largely dominated over bacteria as leaf endophytes and also in the litter immediately before contact with soil, and this fungal dominance lasted until month 4. Bacterial biomass (measured as phospholipid fatty acid content) in litter increased with time but also changed qualitatively, showing an increasing number of Actinobacteria. This paper shows that the dynamics of decomposition of individual litter components changes with time in accordance with the changes in the microbial community composition and its production of extracellular enzymes. 相似文献
995.
Encephalization has many contexts and implications. On one hand, it is concerned with the transformation of eating habits, social relationships and communication, cognitive skills and the mind. Along with the increase in brain size on the other hand, encephalization is connected with the creation of more complex brain structures, namely in the cerebral cortex. It is imperative to inquire into the mechanisms which are linked with brain growth and to find out which of these mechanisms allow it and determine it. There exist a number of theories for understanding human brain evolution which originate from neurological sciences. These theories are the concept of radial units, minicolumns, mirror neurons, and neurocognitive networks. Over the course of evolution, it is evident that a whole range of changes have taken place in regards to heredity. These changes include new mutations of genes in the microcephalin complex, gene duplications, gene co-expression, and genomic imprinting. This complex study of the growth and reorganization of the brain and the functioning of hereditary factors and their external influences creates an opportunity to consider the implications of cultural evolution and cognitive faculties. 相似文献
996.
997.
? Allopolyploidy, a driving force in plant evolution, can induce rapid structural changes in parental subgenomes. Here, we examined the fate of homologous subtelomeric satellites in intrasection allotetraploid Nicotiana arentsii formed from N. undulata and N. wigandioides progenitors < 200,000 yr ago. ? We cloned and sequenced a number of monomers from progenitors and the allotetraploid. Structural features of both cloned and genomic monomers were studied using double-strand conformation polymorphism analysis. ? Two homologous satellites were isolated from N. undulata (called NUNSSP) and N. wigandioides (NWISSP). While the NUNSSP monomers were highly homogeneous in nucleotide sequences, the NWISSP monomers formed two separate clades. Likewise, the genomic NUNSSP monomers showed less DNA conformation heterogeneity than NWISSP monomers, with distinct conformations. While both satellites predominantly occupy subtelomeric positions, a fraction of the NWISSP repeats was found in an intercalary location, supporting the hypothesis that dispersion prevents the repeats becoming homogeneous. Sequence, structural and chromosomal features of the parental satellites were faithfully inherited by N. arentsii. ? Our study revealed that intergenomic homogenization of subtelomeric satellite repeats does not occur in N. arentsii allotetraploid. We propose that the sequence and structural divergence of subtelomeric satellites may render allopolyploid chromosomes less vulnerable to intergenomic exchanges. 相似文献
998.
Lucie Muchova Katerina Vanova Jaroslav Zelenka Martin Lenicek Tomas Petr Martin Vejrazka Eva Sticova Hendrik Jan Vreman Ronald James Wong Libor Vitek 《Journal of cellular and molecular medicine》2011,15(5):1156-1165
High plasma concentrations of bile acids (BA) and bilirubin are hallmarks of cholestasis. BA are implicated in the pathogenesis of cholestatic liver damage through mechanisms involving oxidative stress, whereas bilirubin is a strong antioxidant. We evaluated the roles of bilirubin and BA on mediating oxidative stress in rats following bile duct ligation (BDL). Adult female Wistar and Gunn rats intraperitoneally anaesthetized with ketamine and xylazine underwent BDL or sham operation. Cholestatic markers, antioxidant capacity, lipid peroxidation and heme oxygenase (HO) activity were determined in plasma and/or liver tissue 5 days after surgery. HepG2‐rNtcp cells were used for in vitro experiments. Plasma bilirubin levels in control and BDL animals positively correlated with plasma antioxidant capacity. Peroxyl radical scavenging capacity was significantly higher in the plasma of BDL Wistar rats (210 ± 12%, P < 0.0001) compared to controls, but not in the liver tissues. Furthermore after BDL, lipid peroxidation in the livers increased (179 ± 37%, P < 0.01), whereas liver HO activity significantly decreased to 61% of control levels (P < 0.001). Addition of taurocholic acid (TCA, ≥50 μmol/l) to liver homogenates increased lipid peroxidation (P < 0.01) in Wistar, but not in Gunn rats or after the addition of bilirubin. In HepG2‐rNtcp cells, TCA decreased both HO activity and intracellular bilirubin levels. We conclude that even though plasma bilirubin is a marker of cholestasis and hepatocyte dysfunction, it is also an endogenous antioxidant, which may counteract the pro‐oxidative effects of BA in circulation. However, in an animal model of obstructive cholestasis, we found that BA compromise intracellular bilirubin levels making hepatocytes more susceptible to oxidative damage. 相似文献
999.
1000.
Karin Nuernberg Jaroslav Slamecka Jozef Mojto Jozef Gasparik Gerd Nuernberg 《European Journal of Wildlife Research》2011,57(4):795-803
The aim of this investigation was to characterise the fatty acid composition within intramuscular fat (IMF) of two muscles
(breast and thigh) from 28 pheasants, ten wild ducks and 27 black coots from Slovakia. A high variability for all single fatty
acids (FA) and the total fat concentration in muscles of wild birds was identified. Black coots deposited the highest fat
in breast muscle whereas wild ducks and pheasants accumulated more lipids in thigh muscle. In general, the content of polyunsaturated
fatty acids (PUFA) of the IMF in wild bird muscles was high, and the saturated FA concentration was lower compared with muscles
of domestic farm animals. The ratio between PUFA and saturated fatty acids (PSQ) ranked between 0.6 and 1.2, and the ratio
of n-6/n-3 fatty acid was favourably low in black coot and wild pheasants (3.2 and 2.9, respectively). Farmed pheasants had increased
IMF and more saturated and n-6 fatty acids deposited in thigh muscle but not in breast muscle. 相似文献