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941.
Arne Andersson Per-Ola Carlsson Carina Carlsson Richard Olsson Astrid Nordin Magnus Johansson Fredrik Palm Björn Tyrberg Örjan Källskog Linda Tillmar Nils Welsh Göran Mattsson Leif Jansson 《Cell biochemistry and biophysics》2004,40(3):55
Engraftment (i.e., the adaptation of transplanted pancreatic islets to their new surroundings with regard to revascularization, reinnervation, and reorganization of other stromal compartments) is of crucial importance for the survival and function of the endocrine cells. Previous studies suggest that transplantation induces both vascular and stromal dysfunctions in the implanted islets when compared with endogenous islets. Thus the vascular density and the blood perfusion of islet grafts is decreased and accompanied with a capillary hypertension. This leads to hypoxic conditions, with an associated shift toward anaerobic metabolism in grafted islets. An improved engraftment will prevent or compensate for the vascular/stromal dysfunction seen in transplanted islets and thereby augment survival of the islet implant. By such means the number of islets needed to cure the recipient will be lessened. This will increase the number of patients that can be transplanted with the limited material available. 相似文献
942.
Nuclear protein coding sequences from gymnosperms are currently scarce. We have determined 4 kb of nuclear protein coding sequences from gymnosperms and have collected and analyzed >60 kb of nuclear sequences from gymnosperms and nonspermatophytes in order to better understand processes influencing genome evolution in plants. We show that conifers possess both biased and nonbiased genes with respect to GC content, as found in monocots, suggesting that the common ancestor of conifers and monocots may have possessed both biased and nonbiased genes. The lack of biased genes in dicots is suggested to be a derived character for this lineage. We present a simple but speculative model of land-plant genome evolution which considers changes in GC bias and CpG frequency, respectively, as independent processes and which can account for several puzzling aspects of observed nucleotide frequencies in plant genes.Abbreviations GC
guanosine plus cytosine
- GapC
glycolytic glyceraldehyde-3-phosphate dehydrogenase, EC 1.2.1.12
- GapA
Calvin cycle glyceraldehyde-3-phosphate dehydrogenase, EC 1.2.1.13
- O/E
ratio of observed-to-expected dinucleotide frequencies
Correspondence to: W. Martin 相似文献
943.
J. A. Hokanson B. W. Brown J. R. Thompson B. Jansson B. Drewinkos 《Cell proliferation》1986,19(1):1-10
Abstract. We present a computer-based mathematical model that can simulate characteristic features of the clinical time course of human myeloma. It asserts that therapy resistance in myeloma cells is an inherited trait associated with the longer inter-mitotic times of some cells and that the strength of this trait affects tumour growth characteristics. These kinetic differences within the malignant cell clone may also influence therapeutic efficacy. In the model, the same total therapy, administered in different time-dose fractions, could be 'curative' or 'minimally effective' depending on kinetic properties. For example, as others have shown, in myeloma pulsed intermittent therapy is often more effective than low dose continuous therapy. According to our model this finding is compatible with a high coefficient of inheritability of resistance from one cell generation to the next. the model also suggests that if there are subclones of varying resistance, a therapy must have some effect on each of them if it is to be employed in a curative fashion. While many aspects of the model are not yet clinically testable, exploration of its concepts might increase knowledge about fundamental neoplastic mechanisms. 相似文献
944.
Nematophagous fungi in the rhizosphere of agricultural crops 总被引:1,自引:0,他引:1
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