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881.
Meiyu Cheng Nan Lin Delu Dong Jiaoyan Ma Jing Su Liankun Sun 《European journal of cell biology》2021,100(1):151144
In response to mitochondrial damage, mitochondria activate mitochondrial dynamics to maintain normal functions, and an imbalance in mitochondrial dynamics triggers multiple programmed cell death processes. Recent studies have shown that phosphoglycerate mutase 5 (PGAM5) is associated with mitochondrial damage. PGAM5 activates mitochondrial biogenesis and mitophagy to promote a cellular compensatory response when mitochondria are mildly damaged, whereas severe damage to mitochondria leads to PGAM5 inducing excessive mitochondria fission, disruption to mitochondrial movement, and amplification of apoptosis, necroptosis and mitophagic death signals, which eventually evoke cell death. PGAM5 functions mainly through protein-protein interactions and specific Ser/Thr/His protein phosphatase activity. PGAM5 is also regulated by mitochondrial proteases. Detection of PGAM5 and its interacting protein partners should enable a more accurate evaluation of mitochondrial damage and a more precise method for the diagnosis and treatment of diseases. 相似文献
882.
Kopruszinski Caroline M. Swiokla Juliana Lee Yeon Sun Navratilova Edita VanderVeen Laurie Yang Miao Liu Yi Miyazaki Takahiro Schmidt William K. Zalevsky Jonathan Porreca Frank 《Cellular and molecular neurobiology》2021,41(5):949-960
Cellular and Molecular Neurobiology - Pharmacological evaluation of the mu-opioid receptor (MOR) agonist properties of NKTR-181 in rodent models. Graded noxious stimulus intensities were used in... 相似文献
883.
Molecular Biology Reports - Chemosensory receptors in the dendritic membrane of olfactory cells are critical for the molecular recognition and discrimination of odorants. Tropidothorax elegans is a... 相似文献
884.
Nam Jin-Sik Park Seo-Yeon Lee Seon-Ok Lee Hyo-Jeong Jang Hye-Lim Rhee Young Ha 《Molecular biology reports》2021,48(3):2173-2181
Molecular Biology Reports - The pawpaw tree has several beneficial effects. However, no studies have been conducted to address the mechanisms underlying the cytotoxic effects of pawpaw extracts... 相似文献
885.
Molecular and Cellular Biochemistry - Xp11 translocation renal cell carcinoma (tRCC) characterized by the rearrangement of the TFE3 is recently identified as a unique subtype of RCC that urgently... 相似文献
886.
Weixu Wang Huanhuan Tan Mingwan Sun Yiqing Han Wei Chen Shengnu Qiu Ke Zheng Gang Wei Ting Ni 《Nucleic acids research》2021,49(9):e54
With the tremendous increase of publicly available single-cell RNA-sequencing (scRNA-seq) datasets, bioinformatics methods based on gene co-expression network are becoming efficient tools for analyzing scRNA-seq data, improving cell type prediction accuracy and in turn facilitating biological discovery. However, the current methods are mainly based on overall co-expression correlation and overlook co-expression that exists in only a subset of cells, thus fail to discover certain rare cell types and sensitive to batch effect. Here, we developed independent component analysis-based gene co-expression network inference (ICAnet) that decomposed scRNA-seq data into a series of independent gene expression components and inferred co-expression modules, which improved cell clustering and rare cell-type discovery. ICAnet showed efficient performance for cell clustering and batch integration using scRNA-seq datasets spanning multiple cells/tissues/donors/library types. It works stably on datasets produced by different library construction strategies and with different sequencing depths and cell numbers. We demonstrated the capability of ICAnet to discover rare cell types in multiple independent scRNA-seq datasets from different sources. Importantly, the identified modules activated in acute myeloid leukemia scRNA-seq datasets have the potential to serve as new diagnostic markers. Thus, ICAnet is a competitive tool for cell clustering and biological interpretations of single-cell RNA-seq data analysis. 相似文献
887.
Dong Chengya Wen Shaohong Zhao Shunying Sun Si Zhao Shangfeng Dong Wen Han Pingxin Chen Qingfang Gong Ting Chen Wentao Liu Wenqian Liu Xiangrong 《Neurochemical research》2021,46(4):755-769
Neurochemical Research - Cerebral ischemia leads to reactive astrogliosis and glial scar formation. Glial scarring can impede functional restoration during the recovery phase of stroke. Salidroside... 相似文献
888.
Wang Han Shen Yi-Jia Li Xiu-Juan Xia Jun Sun Li Xu Yehao Ma Yu Li Dai Xiong Yuan-Chang 《Neurochemical research》2021,46(5):1214-1223
Neurochemical Research - Paclitaxel is a common chemotherapeutic agent in cancer treatment, while it often causes chemotherapy-induced peripheral neuropathy (CIPN), which... 相似文献
889.
890.
Wang Guang-Long An Ya-Hong Wang Ya-Hui Liu Jie-Xia Wang Ji-Zhong Sun Min Xiong Ai-Sheng 《Journal of Plant Growth Regulation》2021,40(2):787-797
Journal of Plant Growth Regulation - Gibberellins (GAs) are a group of plant hormones that play important roles in various processes. Previous studies demonstrated that GA can increase the... 相似文献