全文获取类型
收费全文 | 204篇 |
免费 | 10篇 |
专业分类
214篇 |
出版年
2022年 | 1篇 |
2021年 | 3篇 |
2020年 | 4篇 |
2019年 | 1篇 |
2018年 | 8篇 |
2017年 | 8篇 |
2016年 | 4篇 |
2015年 | 8篇 |
2014年 | 12篇 |
2013年 | 12篇 |
2012年 | 14篇 |
2011年 | 10篇 |
2010年 | 7篇 |
2009年 | 3篇 |
2008年 | 5篇 |
2007年 | 10篇 |
2006年 | 8篇 |
2005年 | 5篇 |
2004年 | 7篇 |
2003年 | 4篇 |
2002年 | 10篇 |
2001年 | 3篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 4篇 |
1997年 | 3篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 4篇 |
1991年 | 9篇 |
1990年 | 7篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有214条查询结果,搜索用时 15 毫秒
191.
Ana Patrícia Marques Janete Cunha-Santos Helena Leal Lígia Sousa-Ferreira Luís Pereira de Almeida Cláudia Cavadas Joana Rosmaninho-Salgado 《Biochimica et Biophysica Acta (BBA)/General Subjects》2018,1862(3):403-413
Background
During the development of obesity the expansion of white adipose tissue (WAT) leads to a dysregulation and an excessive remodeling of extracellular matrix (ECM), leading to fibrosis formation. These ECM changes have high impact on WAT physiology and may change obesity progression. Blocking WAT fibrosis may have beneficial effects on the efficacy of diet regimen or therapeutical approaches in obesity. Since dipeptidyl peptidase IV (DPP-IV) inhibitors prevent fibrosis in tissues, such as heart, liver and kidney, the objective of this study was to assess whether vildagliptin, a DPP-IV inhibitor, prevents fibrosis in WAT in a mouse model of obesity, and to investigate the mechanisms underlying this effect.Methods
We evaluated the inhibitory effect of vildagliptin on fibrosis markers on WAT of high-fat diet (HFD)-induced obese mice and on 3T3-L1 cell line of mouse adipocytes treated with a fibrosis inducer, transforming growth factor beta 1 (TGFβ1).Results
Vildagliptin prevents the increase of fibrosis markers in WAT of HFD-fed mice and reduces blood glucose, serum triglycerides, total cholesterol and leptin levels. In the in vitro study, the inhibition of DPP-IV with vildagliptin, neuropeptide Y (NPY) treatment and NPY Y1 receptor activation prevents ECM deposition and fibrosis markers increase induced by TGFβ1 treatment.Conclusions
Vildagliptin prevents fibrosis formation in adipose tissue in obese mice, at least partially through NPY and NPY Y1 receptor activation.General significance
This study highlights the importance of vildagliptin in the treatment of fibrosis that occur in obesity. 相似文献192.
193.
194.
195.
R Jiménez M Burgos A Sánchez R Díaz de la Guardia 《Cytogenetics and cell genetics》1990,53(2-3):97-102
Spermatocytes from the mole, Talpa occidentalis, a species that includes both XX males and intersexes, were surface-spread and silver-stained to substage meiotic prophase from early zygonema through pachynema. In zygonema, only the Z2 and Z3 substages were found. This stage differed in comparison with such species as the Chinese hamster, laboratory mouse, and deer mouse, which belong to orders other than Insectivora. Pachynema, in which five substages were established (P1-P5), seems to be a more homogeneous stage, and remarkable differences with respect to the above-mentioned species were not found. Synaptic adjustment was demonstrated in X-Y pairing. Nonhomologous pairing was evident at the Y-centromeric region and considered likely in the proximal arm of this chromosome. In addition to sequencing the events taking place during zygonema and pachynema in males from a wild population in which some members show sex reversal, our finding represents the first attempt to substage zygonema and pachynema in an Insectivore species, thus contributing to current knowledge of the nature and degree of variability in the mammalian synaptic process. 相似文献
196.
Francisco J. Romera Esteban Alcántara Manuel Díaz de la Guardia 《Physiologia plantarum》1997,101(1):143-148
The effect of bicarbonate and selected metal ions on the development of enhanced root Fe(III) reducing capacity (a response to Fe deficiency of dicotyledons) was studied in young plants of cucumber ( Cucumis sativus L. cv. Ashley) grown in nutrient solution. Pretreatment of 11-day-old Fe-deficient cucumber plants with 20 m M NaHCO3 , for at least 23 h prior to determination of root Fe(III) reducing capacity, markedly inhibited this response. The inhibitory effect of bicarbonate could be partly reversed by a 4- to 8-h treatment with either 10 μ M MnSO4 , 10 μ M FeEDDHA, 2 μ M ZnSO4 , 0.5 μ M NiCl2 , or 0.25 μ M , or CoSO4 (final concentrations), added to the nutrient solution. By contrast, the addition of other salts of metal ions, like CuSO4 and Cd(NO3 )2 , at 0.25, 0.5 or 1 μ M , or MgSO4 , at 0.5, 1 or 2 m M (final concentrations), had no beneficial effect. The results suggest that bicarbonate may inhibit the development of root Fe(III) reducing capacity by diminishing the availability of certain metal ions required for this response. 相似文献
197.
198.
199.
We studied the role of chromatin accessibility and methylation in the banding patterns produced by means of in situ nick-translation (NT) and restriction enzyme (RE) banding techniques. For these studies we used the X chromosomes of Microtus cabrerae because of their large segment with four different types of constitutive heterochromatin and because in these chromosomes we can also compare active and inactive euchromatin. The results demonstrate that constitutive heterochromatin in the X chromosomes of M. cabrerae is methylated at specific sequences in both active and inactive Xs. They also show that NT-based techniques are suitable for detecting weak differences in chromatin accessibility, such as differences between active and inactive euchromatin, and are able to distinguish methylation only at the accessible sites. Thus, when methylation has to be mapped in situ, additional experiments have to be performed in order to distinguish findings due to differential accessibility. RE banding seems less sensitive to slight differences in chromatin accessibility, and might thus be more suitable than in situ NT-based techniques for methylation mapping. In harmony with these results, HpaII-based RE banding is able to distinguish between active and inactive euchromatin, possibly depending on its methylation status. 相似文献
200.
Summary Metalloenzymes as biochemical markers of nutritional status have been studied for 30 years since Brown and Hendricks proposed
the use of enzyme activities as indicators for the diagnosis of micronutrient deficiencies. Enzyme activities can be used
in other lines of research, such as the characterization of particular reactions of genotypes to nutritive imbalances.
Catalase, peroxidase and superoxide dismutase activities were assayed in soybean cultivars growing in nutrient solutions with
different Fe/Mn ratios. Considerable differences were observed between cultivars. Relationships between growth and enzyme
activity were also studied.
Although more information is required, our results provide an introduction to the knowledge of the mechanisms developed by
genotypes in response to Fe−Mn imbalances. 相似文献