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John M. Hancock Niels C. Adams Vassilis Aidinis Andrew Blake Judith A. Blake Molly Bogue Steve D. M. Brown Elissa J. Chesler Duncan Davidson Christopher Duran Janan T. Eppig Valérie Gailus-Durner Hilary Gates Georgios V. Gkoutos Simon Greenaway Martin Hrabé de Angelis George Kollias Sophie Leblanc Kirsty Lee Christoph Lengger Holger Maier Ann-Marie Mallon Hiroshi Masuya David G. Melvin Werner Müller Helen Parkinson Glenn Proctor Eli Reuveni Paul Schofield Aadya Shukla Cynthia Smith Tetsuro Toyoda Laurent Vasseur Shigeharu Wakana Alison Walling Jacqui White Joe Wood Michalis Zouberakis 《Mammalian genome》2008,19(3):219-220
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Blake JA Richardson JE Bult CJ Kadin JA Eppig JT;Mouse Genome Database Group 《Nucleic acids research》2003,31(1):193-195
The Mouse Genome Database (MGD) (http://www.informatics.jax.org) one component of a community database resource for the laboratory mouse, a key model organism for interpreting the human genome and for understanding human biology. MGD strives to provide an extensively integrated information resource with experimental details annotated from both literature and on-line genomic data sources. MGD curates and presents the consensus representation of genotype (sequence) to phenotype information including highly detailed information about genes and gene products. Primary foci of integration are through representations of relationships between genes, sequences and phenotypes. MGD collaborates with other bioinformatics groups to curate a definitive set of information about the laboratory mouse. Recent developments include a general implementation of database structures for controlled vocabularies and the integration of a phenotype classification system. 相似文献
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Ingrid T. Katz Busisiwe Nkala Janan Dietrich Melissa Wallace Linda-Gail Bekker Kathryn Pollenz Laura M. Bogart Alexi A. Wright Alexander C. Tsai David R. Bangsberg Glenda E. Gray 《PloS one》2013,8(8)
Background
In South Africa, the prevalence of oncogenic Human Papillomavirus (HPV) may be as high as 64%, and cervical cancer is the leading cause of cancer-related death among women. The development of efficacious prophylactic vaccines has provided an opportunity for primary prevention. Given the importance of psycho-social forces in vaccine uptake, we sought to elucidate factors influencing HPV vaccination among a sample of low-income South African adolescents receiving the vaccine for the first time in Soweto.Methods
The HPV vaccine was introduced to adolescents in low-income townships throughout South Africa as part of a nationwide trial to understand adolescent involvement in future vaccine research targeting human immunodeficiency virus (HIV). We performed in-depth semi-structured interviews with purposively-sampled adolescents and their care providers to understand what forces shaped HPV vaccine uptake. Interviews were recorded, transcribed, translated, and examined using thematic analysis.Results
Of 224 adolescents recruited, 201 initiated the vaccine; 192 (95.5%) received a second immunization; and 164 (81.6%) completed three doses. In our qualitative study of 39 adolescent-caregiver dyads, we found that factors driving vaccine uptake reflected a socio-cultural backdrop of high HIV endemnicity, sexual violence, poverty, and an abundance of female-headed households. Adolescents exercised a high level of autonomy and often initiated decision-making. Healthcare providers and peers provided support and guidance that was absent at home. The impact of the HIV epidemic on decision-making was substantial, leading participants to mistakenly conflate HPV and HIV.Conclusions
In a setting of perceived rampant sexual violence and epidemic levels of HIV, adolescents and caregivers sought to decrease harm by seeking a vaccine targeting a sexually transmitted infection (STI). Despite careful consenting, there was confusion regarding the vaccine’s target. Future interventions promoting STI vaccines will need to provide substantial information for participants, particularly adolescents who may exercise a significant level of autonomy in decision-making. 相似文献39.
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A mouse phenome project 总被引:3,自引:3,他引:0
A community-wide effort to establish baseline phenotypic data on commonly used and genetically diverse inbred mouse strains
and to provide the information through a publicly accessible database.
Received: 21 April 2000 / Accepted: 25 April 2000 相似文献