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171.
Haiyan Wang Yongyong Yan Janak L. Pathak Wei Hong Jing Zeng Dongyang Qian Binwei Hao Haiqing Li Jinlan Gu Richard T. Jaspers Gang Wu Ming Shao Gongyong Peng Haifeng Lan 《Journal of cellular and molecular medicine》2023,27(4):515-528
Due to the lack of effective treatments, osteoarthritis (OA) remains a challenge for clinicians. Quercetin, a bioflavonoid, has shown potent anti-inflammatory effects. However, its effect on preventing OA progression and the underlying mechanisms are still unclear. In this study, Sprague–Dawley male rats were divided into five groups: control group, OA group (monosodium iodoacetate intra-articular injection), and three quercetin-treated groups. Quercetin-treated groups were treated with intragastric quercetin once a day for 28 days. Gross observation and histopathological analysis showed cartilage degradation and matrix loss in the OA group. High-dose quercetin-group joints showed failure in OA progression. High-dose quercetin inhibited the OA-induced expression of MMP-3, MMP-13, ADAMTS4, and ADAMTS5 and promoted the OA-reduced expression of aggrecan and collagen II. Levels of most inflammatory cytokines and growth factors tested in synovial fluid and serum were upregulated in the OA group and these increases were reversed by high-dose quercetin. Similarly, subchondral trabecular bone was degraded in the OA group and this effect was reversed in the high-dose quercetin group. Our findings indicate that quercetin has a protective effect against OA development and progression possibly via maintaining the inflammatory cascade homeostasis. Therefore, quercetin could be a potential therapeutic agent to prevent OA progression in risk groups. 相似文献
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sec:abstractnak Autonomic computing—self-configuring, self-healing, self-managing applications, systems and networks—is a
promising solution to ever-increasing system complexity and the spiraling costs of human management as systems scale to global
proportions. Most results to date, however, suggest ways to architect new software designed from the ground up as autonomic systems, whereas in the real world organizations continue to use stovepipe
legacy systems and/or build “systems of systems” that draw from a gamut of disparate technologies from numerous vendors. Our
goal is to retrofit autonomic computing onto such systems, externally, without any need to understand, modify or even recompile the target system's
code. We present an autonomic infrastructure that operates similarly to active middleware, to explicitly add autonomic services
to pre-existing systems via continual monitoring and a feedback loop that performs reconfiguration and/or repair as needed.
Our lightweight design and separation of concerns enables easy adoption of individual components for use with a variety of
target systems, independent of the rest of the full infrastructure. This work has been validated by several case studies spanning
multiple real-world application domains. 相似文献
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The uptake and metabolism of 30 micrograms/kg [3H]-Leu-enkephalin ([3H]-LE) following either intraperitoneal (IP) or subcutaneous (SC) administration to Swiss Webster mice was examined. Uptake of [3H] was rapid, with peak levels of radioactivity in plasma observed at 5 or 10 min following IP or SC peptide injection, respectively. The majority (80-99% +/- 0.8) of plasma radioactivity at all postinjection plasma collection time points was in the form of tyrosine-containing enkephalin metabolites, indicating a substantial and rapid in vivo hydrolysis rate for exogenously administered LE. Leu-enkephalin is metabolized in vivo faster than previously reported in vitro in mouse plasma. However, despite this extensive hydrolysis, levels of intact LE remaining in plasma following its systemic administration are within or above endogenous LE plasma levels. 相似文献
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THE EVOLUTION AND ANATOMY OF THE CEREBELLUM 总被引:2,自引:0,他引:2