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41.
Four new leaf mutants, crinkled-leaf, waxy-leaf, narrow-leaf and unifoliate were induced in black gram, Phaseolus mungo, following treatments with X-rays and/or ethyl methanesulfonate (EMS). The crinkled-leaf and waxy-leaf mutants had normal fertility and vitality, whereas the narrow-leaf mutant was partially sterile and the unifoliate (an extreme dwarf) completely sterile. All the mutants except unifoliate behaved as monogenic recessive to the normal. 相似文献
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Simon Borna Ales Drobek Jarmila Kralova Daniela Glatzova Iva Splichalova Matej Fabisik Jana Pokorna Tereza Skopcova Pavla Angelisova Veronika Kanderova Julia Starkova Petr Stanek Orest V. Matveichuk Nataliia Pavliuchenko Katarzyna Kwiatkowska Majd B. Protty Michael G. Tomlinson Meritxell Alberich‐Jorda Vladimir Korinek Tomas Brdicka 《Journal of cellular and molecular medicine》2020,24(2):1980-1992
WW domain binding protein 1‐like (WBP1L), also known as outcome predictor of acute leukaemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which correlates with ETV6‐RUNX1 (t(12;21)(p13;q22)) translocation and favourable prognosis in childhood leukaemia. It has a broad expression pattern in haematopoietic and in non‐haematopoietic cells. However, its physiological function has been unknown. Here, we show that WBP1L negatively regulates signalling through a critical chemokine receptor CXCR4 in multiple leucocyte subsets and cell lines. We also show that WBP1L interacts with NEDD4‐family ubiquitin ligases and regulates CXCR4 ubiquitination and expression. Moreover, analysis of Wbp1l‐deficient mice revealed alterations in B cell development and enhanced efficiency of bone marrow cell transplantation. Collectively, our data show that WBP1L is a novel regulator of CXCR4 signalling and haematopoiesis. 相似文献
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Guilherme Jeremias Fernando J. M. Gonalves Joana L. Pereira Jana Asselman 《Biological reviews of the Cambridge Philosophical Society》2020,95(3):822-846
Epigenetic mechanisms have gained relevance in human health and environmental studies, due to their pivotal role in disease, gene × environment interactions and adaptation to environmental change and/or contamination. Epigenetic mechanisms are highly responsive to external stimuli and a wide range of chemicals has been shown to determine specific epigenetic patterns in several organisms. Furthermore, the mitotic/meiotic inheritance of such epigenetic marks as well as the resulting changes in gene expression and cell/organismal phenotypes has now been demonstrated. Therefore, epigenetic signatures are interesting candidates for linking environmental exposures to disease as well as informing on past exposures to stressors. Accordingly, epigenetic biomarkers could be useful tools in both prospective and retrospective risk assessment but epigenetic endpoints are currently not yet incorporated into risk assessments. Achieving a better understanding on this apparent impasse, as well as identifying routes to promote the application of epigenetic biomarkers within environmental risk assessment frameworks are the objectives of this review. We first compile evidence from human health studies supporting the use of epigenetic exposure‐associated changes as reliable biomarkers of exposure. Then, specifically focusing on environmental science, we examine the potential and challenges of developing epigenetic biomarkers for environmental fields, and discuss useful organisms and appropriate sequencing techniques to foster their development in this context. Finally, we discuss the practical incorporation of epigenetic biomarkers in the environmental risk assessment of chemicals, highlighting critical data gaps and making key recommendations for future research within a regulatory context. 相似文献
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Alexandre P. Hercos Ana Carolina Prado-Valladares Jana M. del Favero Nagila A. Zuchi Túlio F. Teixeira Fábio E. A. Albuquerque Helder L. de Queiroz 《Zeitschrift fur angewandte Ichthyologie》2021,37(6):985-988
Length-weight relationships (LWRs) were estimated for 16 ornamental fish species from Amanã Lake and nine tributary streams, in Central Brazilian Amazonia. Sampling was carried out bimonthly for a year (2007–2008), using two sets of four gillnets (20 m × 2 m, 2,5; 3,5; 04; 4,5 cm stretch mesh size); trawls were performed with seine nets (35 m × 6 m, 3 mm stretch mesh size); native fish-traps (fyke-net like fish-traps woven from local lianas), and dip nets (0.5 m × 0.5 m stretch mesh size). Measurements were done for standard length (SL – 0.1 cm precision) and total weight (Wt – 0.01 g precision). This study provides information on the length–weight relationships for all sampled species and, in addition, provides new maximum standard lengths for six species. 相似文献
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Kalocayova Barbora Snurikova Denisa Vlkovicova Jana Navarova-Stara Veronika Michalikova Dominika Ujhazy Eduard Gasparova Zdenka Vrbjar Norbert 《Molecular and cellular biochemistry》2021,476(12):4323-4330
Molecular and Cellular Biochemistry - Previously it was shown that for reduction of anxiety and stress of experimental animals, preventive handling seems to be one of the most effective methods.... 相似文献
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