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Dieback and canker diseases are a major problem in ornamental shrubs and trees of Ahvaz, southwestern Iran. Symptomatic stems and branches were collected from two urban parks in the downtown regions of Ahvaz to identify the dieback-causing agents of Lantana camara. Accordingly, two isolates of a new species, Allophoma hayatii sp. nov., were obtained, which are described and illustrated. This species is identified based on morphological characters and analyses of nucleotide sequences of four regions, including internal transcribed spacer 1 and 2 and 5.8S nrDNA (ITS), partial large subunit 28S nrDNA (LSU-D1/D2), a partial sequence of the β-tubulin (tub2) and part of the RNA polymerase II (rpb2). The isolates of A. hayatii generated a well-supported clade in the trees constructed from multi-locus phylogenetic analysis, distinct from other previously known species of Allophoma. Pathogenicity of both isolates was verified by the inoculation of stem fragments of L. camara. These findings confirm A. hayatii as the causal agents of dieback and canker of L. camara in Ahvaz. 相似文献
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Enhancement of muscarinic receptor-coupled phosphatidyl inositol hydrolysis in diabetic bladder 总被引:1,自引:0,他引:1
Hiromitsu Mimata Marcia A. Wheeler Yuji Fukumoto Hiroshi Takigawa Tadashi Nishimoto Robert M. Weiss Jamshid Latifpour 《Molecular and cellular biochemistry》1995,152(1):71-76
We previously have shown an increase in muscarinic receptor density in streptozotocin (STZ)-induced diabetic and sucrosefed diuretic rat detrusor that correlates with an increase in the contractile response to muscarinic agonist (J Pharmacol Exp Ther 248: 81, 1989; Diabetes 40: 265, 1991). To investigate the signal transduction pathway involved in this altered functional response, we examined muscarinic receptor-coupled phosphatidylinositol metabolism in STZ-diabetic, sucrose-fed diuretic and age-matched control rat bladders. [3H]myo-inositol uptake was similar in all groups, but incorporation of myo-inositol into phosphatidylinositol (PI) was significantly increased in the diabetic bladder compared to the sucrose-fed and control rat bladders. Carbachol-induced increase in inositol phosphate (IPs) production was higher in the diabetic bladder than in bladders from control and sucrose-fed animals although the EC50 values were similar for all groups. Enhanced inositol phosphate production after muscarinic agonist stimulation may be due not only to the upregulation of muscarinic receptors but also to the increased incorporation of myo-inositol into PI in the STZ-induced diabetic bladder. 相似文献
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Jonas Eriksson Ström Jamshid Pourazar Robert Linder Anders Blomberg Anne Lindberg Anders Bucht Annelie F. Behndig 《Respiratory research》2018,19(1):244
Background
Cytotoxic lymphocytes are increased in the airways of COPD patients. Whether this increase is driven primarily by the disease or by smoking is not clear, nor whether it correlates with the rate of decline in lung function.Methods
Bronchoscopy with BAL was performed in 52 subjects recruited from the longitudinal OLIN COPD study according to pre-determined criteria; 12 with COPD and a rapid decline in lung function (loss of FEV1?≥?60?ml/year), 10 with COPD and a non-rapid decline in lung function (loss of FEV1?≤?30?ml/year), 15 current and ex-smokers and 15 non-smokers with normal lung function. BAL lymphocyte subsets were determined using flow cytometry.Results
In BAL fluid, the proportions of NK, iNKT and NKT-like cells all increased with pack-years. Within the COPD group, NK cells – but not iNKT or NKT-like cells – were significantly elevated also in subjects that had quit smoking. In contrast, current smoking was associated with a marked increase in iNKT and NKT-like cells but not in NK cells. Rate of lung function decline did not significantly affect any of the results.Conclusions
In summary, increased proportions of NK cells in BAL fluid were associated with COPD; iNKT and NKT-like cells with current smoking but not with COPD. Interestingly, NK cell percentages did not normalize in COPD subjects that had quit smoking, indicating that these cells might play a role in the continued disease progression seen in COPD even after smoking cessation.Trial registration
Clinicaltrials.gov identifier NCT02729220.46.
Maryam Ebrahimi Nik Amir Abbas Momtazi-Borojeni Parvin Zamani Jamshid Gholizadeh Navashenaq Mehrdad Iranshahi Mahmoud Reza Jaafari Bizhan Malaekeh-Nikouei 《Journal of cellular physiology》2019,234(9):14721-14733
A number of antiangiogenic drugs have been approved by the Food and Drug Administration which are used in cancer therapy, and variety of other agents in several stages of clinical development or in preclinical assessment. Among these, combretastatin A4 (CA-4) is an under-researched inhibitor of angiogenesis that shows potential activity in the treatment of advanced tumors with migration capacity. However, its clinical application has been limited due to poor water solubility, low bioavailability, rapid metabolism, and systemic elimination. During the last decade, numerous investigations have been done to overcome these problems by using different CA-4 delivery systems or developing produgs of CA-4 or its structural analogs. Nevertheless, these strategies could not be efficient out of the undesired side effects on normal tissues. Nanoliposomal CA-4 not only benefits from the advantage of using liposomal drugs as opposed to free drugs but also can accumulate in the tumor site via specific targeting ligands, which leads to efficient targeting and enhancement of bioavailability. To the best of our knowledge, we consider an important attempt to understand different factors that might influence the CA-4 loading and release pattern of liposomes and the consequent results in tumor therapy. In this review, we shed light on various studied liposomal CA-4 formulations showing application thereof in cancer treatment. 相似文献
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Mahmoud Hassani Fatemeh Hajari Taheri Zahra Sharifzadeh Arash Arashkia Jamshid Hadjati Wytske M. van Weerden Mohammad Hossein Modarressi Mohsen Abolhassani 《Journal of cellular biochemistry》2019,120(6):10787-10795
Adoptive transfer of T cells expressing chimeric antigen receptors (CARs) is considered to be a novel anticancer therapy. To date, in most cases, single-chain variable fragments (scFvs) of murine origin have been used in CARs. However, this structure has limitations relating to the potential immunogenicity of mouse antigens in humans and the relatively large size of scFvs. For the first time, we used camelid nanobody (VHH) to construct CAR T cells against prostate specific membrane antigen (PSMA). The nanobody against PSMA (NBP) was used to show the feasibility of CAR T cells against prostate cancer cells. T cells were transfected, and then the surface expression of the CAR T cells was confirmed. Then, the functions of VHH-CAR T cell were evaluated upon coculture with prostate cancer cells. At the end, the cytotoxicity potential of NBPII-CAR in T cells was approximated by determining the cell surface expression of CD107a after encountering PSMA. Our data show the specificity of VHH-CAR T cells against PSMA+ cells (LNCaP), not only by increasing the interleukin 2 (IL-2) cytokine (about 400 pg/mL), but also the expression of CD69 by almost 38%. In addition, VHH-CAR T cells were proliferated by nearly 60% when cocultured with LNCaP, as compared with PSMA negative prostate cancer cell (DU-145), which led to the upregulation of CD107a in T cells upto 31%. These results clearly show the possibility of using VHH-based CAR T cells for targeted immunotherapy, which may be developed to target virtually any tumor-associated antigen for adoptive T-cell immunotherapy of solid tumors. 相似文献
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Cheraghi Hossein Zendehdel Morteza GhiasiGhalehkandi Jamshid Tajik Parviz Panahi Negar 《International journal of peptide research and therapeutics》2019,25(3):1105-1111
International Journal of Peptide Research and Therapeutics - The correlation between leptin, nutritional status and reproductive performance is known but its effect on male obese is not fully... 相似文献
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Jamshid J. Tehrani 《Evolution》2011,4(3):390-396
Ever since the publication of The Origin of Species, anthropologists and archaeologists have been in turns enchanted and repulsed by the idea that cultural diversity can be
explained by a Darwinian model of descent with modification. Over the last decade, this debate has intensified following the
publication of a number of studies that have sought to reconstruct cultural histories using modern computational methods of
phylogenetic analysis imported from biology. In this paper, I focus on evolution of tribal textile assemblages in Iran and
Central Asia. Using cladistic phylogenetic analysis, I show that similarities and differences among the assemblages can be
largely explained in terms of descent with modification from ancestral assemblages. Interestingly, the phylogenetic signal
in design characters is just as strong (if not stronger) than the signal in technical characters. This may seem surprising
given that techniques, like genes, are transmitted “vertically” from mothers to daughters whereas designs are frequently transmitted
“horizontally” among peers. However, a closer examination reveals that the transmission of designs between weavers mainly
occurs within, rather than between groups, and that, as in many cultures past and present, there are important constraints
on the latter. This highlights that differences in the ways in which genes and cultural traits are transmitted among individuals
should not be assumed to lead to differences in macro-level patterns of evolution, as many archaeologists and anthropologists
have supposed. 相似文献