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781.
Ping Wang Lin Zhou Pierce Jamieson Lin Zhang Zhixue Zhao Kevin Babilonia Wenyong Shao Lizhu Wu Roma Mustafa Imran Amin Alessandra Diomaiuti Daniela Pontiggia Simone Ferrari Yuxia Hou Ping He Libo Shan 《The Plant cell》2020,32(12):3978
Plant receptor-like kinases (RLKs) are important players in response to pathogen infections. Verticillium and Fusarium wilts, caused by Verticillium dahliae (Vd) and Fusarium oxysporum f. sp vasinfectum (Fov), respectively, are among the most devastating diseases in cotton (Gossypium spp). To understand the cotton response to these soil-borne fungal pathogens, we performed a genome-wide in silico characterization and functional screen of diverse RLKs for their involvement in cotton wilt diseases. We identified Gossypium hirsutum GhWAK7A, a wall-associated kinase, that positively regulates cotton response to both Vd and Fov infections. Chitin, the major constituent of the fungal cell wall, is perceived by lysin-motif-containing RLKs (LYKs/CERK1), leading to the activation of plant defense against fungal pathogens. A conserved chitin sensing and signaling system is present in cotton, including chitin-induced GhLYK5-GhCERK1 dimerization and phosphorylation, and contributes to cotton defense against Vd and Fov. Importantly, GhWAK7A directly interacts with both GhLYK5 and GhCERK1 and promotes chitin-induced GhLYK5-GhCERK1 dimerization. GhWAK7A phosphorylates GhLYK5, which itself does not have kinase activity, but requires phosphorylation for its function. Consequently, GhWAK7A plays a crucial role in chitin-induced responses. Thus, our data reveal GhWAK7A as an important component in cotton response to fungal wilt pathogens by complexing with the chitin receptors. 相似文献
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Liver slices from control and inflamed rats were incubated in McCoy's medium and incorporation of [3H]leucine into liver and medium proteins and into albumin and alpha 1-acid glycoprotein was monitored over 48 hr. The release of the new acute phase reactant, sialyltransferase was also monitored in this system. Earlier observations in which liver slices were incubated for 6 hr showed that increased leucine incorporation into liver and medium proteins and alpha 1-acid glycoprotein, coupled with decreased incorporation into albumin, correlated with the acute phase response of these proteins. Increased incorporation of leucine into these proteins was found following 48 hr incubation in McCoy's medium showing that slices were able to express the changes characteristic of the acute phase response over this longer time period of incubation. Sialyltransferase was released into medium in a linear fashion up to 15 hr and continued to increase for 30 hr in this system; there was a substantial increase in release of enzyme activity from slices from inflamed rats when compared to controls. Monokine-conditioned medium prepared from peritoneal exudate cells isolated from rats at various times after lipopolysaccharide administration was used to induce the acute phase response by intraperitoneal injection. Slices were prepared from these rats and sialyltransferase release from slices was monitored. Monokines prepared from peritoneal exudate cells isolated from rats at about 30 hr were most effective in stimulating sialyltransferase release from liver slices. 相似文献
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Léa Cristina Castellucci Lucas Frederico de Almeida Sarra Elisabeth Jamieson Michaela Fakiola Edgar Marcelino de Carvalho Jenefer Mary Blackwell 《Memórias do Instituto Oswaldo Cruz》2014,109(3):279-288
American cutaneous leishmaniasis (ACL) is a vector-transmitted infectious disease
with an estimated 1.5 million new cases per year. In Brazil, ACL represents a
significant public health problem, with approximately 30,000 new reported cases
annually, representing an incidence of 18.5 cases per 100,000 inhabitants. Corte de
Pedra is in a region endemic for ACL in the state of Bahia (BA), northeastern Brazil,
with 500-1,300 patients treated annually. Over the last decade, population and
family-based candidate gene studies were conducted in Corte de Pedra, founded on
previous knowledge from studies on mice and humans. Notwithstanding limitations
related to sample size and power, these studies contribute important genetic
biomarkers that identify novel pathways of disease pathogenesis and possible new
therapeutic targets. The present paper is a narrative review about ACL immunogenetics
in BA, highlighting in particular the interacting roles of the wound healing gene
FLI1 with interleukin-6 and genes SMAD2 and
SMAD3 of the transforming growth factor beta signalling pathway.
This research highlights the need for well-powered genetic and functional studies on
Leishmania braziliensis infection as essential to define and
validate the role of host genes in determining resistance/susceptibility regarding
this disease. 相似文献
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