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201.
A.Ian Scott L.C. Beadling N.H. Georgopapadakou C.R. Subbarayan 《Bioorganic chemistry》1974,3(2):238-248
6-MSA3 synthase has been purified 190-fold with 33% yield. The purification was found to be dependent on the presence of glycerol. The acetylenic inhibitors 3-pentynoyl- and 2-hexynoyl-NAC completely inhibit 6-MSA production at concentrations in which fatty acid synthesis, TAL production as well as NADPH oxidation are only partially affected. These results confirm earlier studies on the specificity of inhibition by acetylenic inhibitors and support a mechanism wherein the NADPH-mediated reduction step occurs on a 6-carbon rather than on an 8-carbon intermediate. 相似文献
202.
Acid -glucosidase in amniotic fluid 总被引:2,自引:0,他引:2
A L Fluharty M L Scott M T Porter H Kihara M G Wilson J W Towner 《Biochemical medicine》1973,7(1):39-51
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208.
T. Gilbert Scott 《The Histochemical journal》1969,1(3):215-229
Synopsis A method for the photometric assay of 5-nucleotidase in histochemical preparations of brain is described. The method, which is based upon the determination of the specular density under the microscope of the final reaction product, is shown to be valid statistically because of the correlation of the values obtained by it with those obtained by biochemical assay of the enzyme in adjacent sections. Correlation of the specular density with the amount of lead in the final reaction product is also shown. The accuracy of the method of assay is good as judged by a coefficient of variation of 9.1% in a series of replicate measurements. The assay of the amount of enzymic activity by this method shows that it is linearly proportional to the incubation time for periods of up to 2 hr, and also for sections ranging in thickness from 5 to 20 . 相似文献
209.
D. Crowther C. J. T. Bateman C. P. Vartan J. M. A. Whitehouse J. S. Malpas G. Hamilton Fairley Ronald Bodley Scott 《BMJ (Clinical research ed.)》1970,4(5734):513-517
Cytosine arabinoside and daunorubicin used in an intensive intermittent regimen have been shown to be an effective combination for the induction of complete remissions in 14 out of 23 adult patients with acute myelogenous leukaemia. This gives an overall complete remission rate of 60%. A further patient had a good partial remission. The addition of L-asparaginase to the regimen has not increased the incidence of remission and there were more side effects in the L-asparaginasetreated group. Of the 10 patients treated with L-asparaginase in addition to cytosine arabinoside and daunorubicin, five achieved a complete remission. Of the 13 patients treated with cytosine arabinoside and daunorubicin without L-asparaginase, nine achieved a complete remission and one a good partial remission. 相似文献
210.
R. Morley D. W. Eccleston C. P. Douglas W. E. J. Greville D. J. Scott J. Anderson 《BMJ (Clinical research ed.)》1970,3(5720):442-443
Three cases of xylene poisoning occurred after prolonged inhalation of paint fumes. Analysis showed that xylene comprised more than 90% of the solvent in the paint, the total solvent comprising 34% of the paint by weight. One patient was dead on admission, while the other two recovered after at least 15 hours'' loss of consciousness. Both patients had transient liver cell damage, and one temporary impairment of renal function. 相似文献