全文获取类型
收费全文 | 109510篇 |
免费 | 9968篇 |
国内免费 | 69篇 |
出版年
2022年 | 623篇 |
2021年 | 1453篇 |
2020年 | 902篇 |
2019年 | 1109篇 |
2018年 | 1429篇 |
2017年 | 1324篇 |
2016年 | 2206篇 |
2015年 | 3694篇 |
2014年 | 4202篇 |
2013年 | 5481篇 |
2012年 | 7026篇 |
2011年 | 7078篇 |
2010年 | 4652篇 |
2009年 | 4190篇 |
2008年 | 5999篇 |
2007年 | 6287篇 |
2006年 | 6104篇 |
2005年 | 5754篇 |
2004年 | 5680篇 |
2003年 | 5460篇 |
2002年 | 5141篇 |
2001年 | 1169篇 |
2000年 | 864篇 |
1999年 | 1299篇 |
1998年 | 1568篇 |
1997年 | 1157篇 |
1996年 | 1037篇 |
1995年 | 981篇 |
1994年 | 936篇 |
1993年 | 1004篇 |
1992年 | 1004篇 |
1991年 | 860篇 |
1990年 | 832篇 |
1989年 | 806篇 |
1988年 | 793篇 |
1987年 | 745篇 |
1986年 | 782篇 |
1985年 | 861篇 |
1984年 | 1052篇 |
1983年 | 906篇 |
1982年 | 1124篇 |
1981年 | 1178篇 |
1980年 | 1037篇 |
1979年 | 714篇 |
1978年 | 778篇 |
1977年 | 724篇 |
1976年 | 698篇 |
1975年 | 559篇 |
1974年 | 668篇 |
1973年 | 613篇 |
排序方式: 共有10000条查询结果,搜索用时 203 毫秒
151.
Lens regeneration in adult salamanders occurs at the pupillary margin of the mid-dorsal iris where pigmented epithelial cells (PEC) re-enter the cell cycle and transdifferentiate into lens. It is not understood how the injury caused by removal of the lens (lentectomy) in one location is linked to initiating the response in a different spatial location (dorsal iris) and to this particular sector. We propose that the blood provides a link between the localised coagulation and signal transduction pathways that lead to regeneration. A transmembrane protein (tissue factor) is expressed in a striking patch-like domain in the dorsal iris of the newt that localises coagulation specifically to this location, but is not expressed in the axolotl, a related species that does not show thrombin activation after lentectomy and cannot regenerate its lens. Our hypothesis is that tissue factor expression localises the initiation of regeneration through the activation of thrombin and the recruitment of blood cells, leading to local growth factor release. This is the first example of gene expression in a patch of cells that prefigures the location of a regenerative response, and links the immune system with the initiation of a regenerative program. 相似文献
152.
Willoughby de Broke Rudyard Kipling Hugh Elliot E. Ray Lankester Leonard Hill Laurence R. Philipps Wm. Arbuthnot Lane James Crichton-Browne H. Bryan Donkin Francis Lloyd R. A. Lyster John MacAlister F. W. Mott William Osler C. W. Saleeby J. H. Sequeira Humphry Rolleston Hugh Wansey Bayly 《BMJ (Clinical research ed.)》1919,2(3074):725
153.
154.
155.
156.
157.
Summary Eight Hawaiian Dubautia species grow in habitats as varied as exposed lava, dry scrub, mesic forest, wet forest, and bog. These species also differ in diploid chromosome number, with four species having 13 pairs of chromosomes and four species having 14 pairs. This ecological and chromosomal variation is paralleled by significant interspecific variation in tissue elastic properties. The four 13-paired species from dry habitats exhibit significantly lower tissue elastic moduli near full hydration (E
i) than the four 14-paired species from mesic to wet habitats. Values of E
i range from 2 to 4 MPa among the former species and from 9 to 18 MPa among the latter species. The turgor dependence of the elastic modulus also differs markedly between the two groups of species. As a result of these differences in tissue elastic properties, the capacity for maintaining high turgor pressures as tissue water content decreases is much greater in the 13-paired species from dry habitats than in the 14-paired species from mesic to wet habitats. These results indicate that the evolutionary diversification of the Dubautia species has been accompanied by a significant degree of change at the physiological level. 相似文献
158.
159.
The Escherichia coli dnaW mutation is an allele of the adk gene 总被引:3,自引:0,他引:3
Joan M. Henson Aleksandra Blinkowa James R. Walker 《Molecular & general genetics : MGG》1982,186(4):488-492
Summary A dnaW mutant, isolated on the basis of inability to effect conjugal DNA transfer at high temperature, has been shown by complementation and enzyme assay to be defective in the adk (adenylate kinase; EC 2.7.4.3) locus. The adk mutant, known to have reduced ATP concentration at the nonpermissive temperature (Cousin and Belaich 1966), was used to demonstrate a donor energy requirement for stable aggregate formation and for chromosome transfer in conjugation. 相似文献
160.