排序方式: 共有27条查询结果,搜索用时 15 毫秒
11.
Muhammad Kamran Fabrizio Frontalini Dang-Peng Xi Kamran Mirza Arman Jafarian Khalid Latif Fahad Ali Muhammad Kashif Nadir Fawad Muhammad Shafi Xiao-Qiao Wan 《Palaeoworld》2021,30(2):337-355
The Middle Eocene Climatic Optimum (MECO) at ~40 Ma is a significant global warming event associated with pronounced changes in the hydrosphere, atmosphere, and biosphere. The Kohat Formation in the Kohat Basin (eastern Tethys, Pakistan) is studied for identifying the response of larger benthic foraminifera (LBF) to MECO. The LBF assemblages in the Kohat Formation, covering from the Shallow Benthic Zones (SBZ) 15 to 17, suggest middle Lutetian to early Bartonian in age. Microfacies analyses indicate a lagoonal (inner carbonate ramp facies belt) to open marine (middle carbonate ramp facies belt) paleodepositional environment of the Kohat Formation. A distinct positive δ13C shift marks the stratigraphic position of the MECO in this formation. At the Peak-MECO event that is marked by the onset of the positive carbon isotope excursion (CIE), no evident compositional variation in the LBF assemblages is observed. However, significant changes in the LBF assemblages with the local first and last occurrences of some LBF genera can be observed in the Post-MECO and CIE recovery phase. These changes are verified by the sudden disappearance of Alveolina and orthophragminids and initial dominance of larger shell-size Nummulites fabianii, Heterostegina, and Linderina species accompanied by an increase in the species diversity. Here, we argue that the change in the observed LBF assemblages in the uppermost part of the Kohat Formation might be related to a larger foraminiferal turnover occurring during the Post-MECO event and corresponds to the CIE recovery phase. 相似文献
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Heat shock protein 70 modulates neural progenitor cells dynamics in human neuroblastoma SH‐SY5Y cells exposed to high glucose content
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14.
Behboodi Negin Farazestanian Marjaneh Rastgar-Moghadam Azam Mehramiz Mehrane Karimi Ehsan Rajabian Majid Rahmani Farzad Khorrami Shadi Jafarian Amirhosein Sharifi-Sistani Noorieh Ferns Gordon A. Avan Amir Hasanzadeh Malihe 《Molecular biology reports》2021,48(2):1433-1437
Molecular Biology Reports - Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine involved in the regulation of the immune system and potentially the progression of cervical... 相似文献
15.
Immunolocalization of Na+/K+‐ATPase,Na+/K+/2Cl− co‐transporter (NKCC) and mRNA expression of Na+/K+‐ATPase α‐subunit during short‐term salinity transfer in the gills of Persian sturgeon (Acipenser persicus,Borodin, 1897) juveniles
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S. A. Shirangi M. R. Kalbassi S. Khodabandeh H. Jafarian J.‐H. Lignot 《Zeitschrift fur angewandte Ichthyologie》2017,33(3):347-353
The study tests the physiological responses of Persian sturgeon, Acipenser persicus, during the abrupt release of juveniles from freshwater (FW) into brackish waters (BW = 11‰) of the Caspian Sea. Fish weight at release was 2‐3 g (2.55 ± 0.41 g; 8.8 ± 0.58 cm TL). Totals of 160 individuals were randomly distributed into four fiber‐glass aerated tanks (volume 60‐L). Two tanks served as controls (FW groups), and two as exposure tanks for BW (Caspian Sea water = CSW). Fish were sampled at 0, 3, 6, 12, 24, 48 and 96 hr after abrupt transfer to CSW. Plasma osmolality, immunolocalization of Na+, K+ ‐ATPase (NKA) and Na+/K+/2Cl– (NKCC) Co‐transporter, NKA activity and the NKA α‐subunit mRNA expression were analyzed. Blood osmolality of fish transferred from FW to CSW increased significantly within hours post‐transfer (p < .05) and remained at a high level for up to 96 hr. Immunolocalization of NKCC indicated co‐localization with NKA in the chloride cells in the gill epithelium. A partial sequence of the NKA α‐subunit (632 bp) is described. Its expression levels were up‐regulated at 12 and 48 hr following salinity transfer (p < .05). However, NKA activity sharply increased in CSW specimens by almost 2.8‐fold (p < .05) between 48 and 96 hr after transfer. Gill NKCC co‐transporter abundance increased, coinciding with increased gill NKA activity. The increased activity of NKCC during salt excretion in CSW may lead to an influx of Na+ into the chloride cells. Consequently, NKA activity increases to maintain intracellular Na+ homeostasis. 相似文献
16.
Larijani B Arjmand B Amoli MM Ao Z Jafarian A Mahdavi-Mazdah M Ghanaati H Baradar-Jalili R Sharghi S Norouzi-Javidan A Aghayan HR 《Cell and tissue banking》2012,13(4):569-575
It has been predicted that one of the greatest increase in prevalence of diabetes will happen in the Middle East bear in the next decades. The aim of standard therapeutic strategies for diabetes is better control of complications. In contrast, some new strategies like cell and gene therapy have aimed to cure the disease. In recent years, significant progress has occurred in beta-cell replacement therapies with a progressive improvement of short-term and long term outcomes. In year 2005, considering the impact of the disease in Iran and the promising results of the Edmonton protocol, the funding for establishing a current Good Manufacturing Practice (cGMP) islet processing facility by Endocrinology and Metabolism Research Center was approved by Tehran University of Medical Sciences. Several islet isolations were performed following establishment of cGMP facility and recruitment of all required equipments for process validation and experimental purpose. Finally the first successful clinical islet isolation and transplantation was performed in September 2010. In spite of a high cost of the procedure it is considered beneficial and may prevent long term complications and the costs associated with secondary cares. In this article we will briefly describe our experience in setting up a cGMP islet processing facility which can provide valuable information for regional countries interested to establish similar facilities. 相似文献
17.
Aghamaali MR Jafarian V Sariri R Molakarimi M Rasti B Taghdir M Sajedi RH Hosseinkhani S 《The protein journal》2011,30(8):566-574
A comparison of the two most famous groups of calcium-regulated photoproteins, cnidarians and ctenophores, showed unexpectedly
high degree of structural similarity regardless of their low sequence identity. It was suggested these photoproteins can play
an important role in understanding the structural basis of bioluminescence activity. Based on this postulate, in this study
the cDNA of mnemiopsin from luminous ctenophore Mnemiopsis
leidyi was cloned, expressed, purified and sequenced. The purified cDNA, with 621 base pairs, coded a 206 residues protein. Sequence
of mnemiopsin showed 93.5 and 51% similarity to other ctenophore proteins and cnidarians, respectively. The cDNA encoding
apo-mnemiopsin of M. leidyi was expressed in Escherichia coli. The purified apo-protein showed a single band on SDS-PAGE (molecular weight ~27 kDa). A semi-synthetic mnemiopsin was prepared
using coelenterazine and EDTA and its luminescence activity was measured in the presence of CaCl2. The results showed an optimum pH of 9.0 and lower calcium sensitivity compared to aequorin. Comparison of amino acid residues
in substrate binding site indicated that binding pocket of ctenophores contains less aromatic residues than cnidarians. This
can lead to a decline in the number of stacking interactions between substrate and protein which can affect the stability
of coelenterazine in binding cavity. Structural comparison of photoproteins with low sequence identity and high 3D structural
similarity, can present a new insight into the mechanism of light emission in photoproteins. 相似文献
18.
Jaleh Varshosaz Abbas Jafarian Golnaz Salehi Behzad Zolfaghari 《Journal of liposome research》2014,24(3):191-203
Quercetin (QT) is a potential chemotherapeutic drug with low solubility that seriously limits its clinical use. The aim of this study was enhancing cellular penetration of QT by sterol containing solid lipid nanoparticles (SLNs) which make bilayers fluent for targeting hepatocellular carcinoma cells. Three variables including sterol type (cholesterol, stigmasterol and stigmastanol), drug and sterol content were studied in a surface response D-optimal design for preparation of QT-SLNs by emulsification solvent evaporation method. The studied responses included particle size, zeta potential, drug loading capacity and 24?h release efficiency (RE24%). Scanning electron and atomic force microscopy were used to study the morphology of QT-SLNs and their thermal behavior was studied by DSC analysis. Cytotoxicity of QT-SLNs was determined by MTT assay on HepG-2 cells and cellular uptake by fluorescence microscopy method. Optimized QT-SLNs obtained from cholesterol and QT with the ratio of 2:1 that showed particle size of 78.0?±?7.0?nm, zeta potential of??22.7?±?1.3?mV, drug loading efficiency of 99.9?±?0.5% and RE24 of 56.3?±?3.4%. IC50 of QT in cholesterol SLNs was about six and two times less than free QT and phytosterol SLNs, respectively, and caused more accumulation of QT in HepG2 cells. Blank phytosterol SLNs were toxic on cells. 相似文献
19.
Mohammadzadeh Ali Masdari Mohammad Gharehchopogh Farhad Soleimanian Jafarian Ahmad 《Cluster computing》2021,24(2):1479-1503
Cluster Computing - Workflow is composed of some interdependent tasks and workflow scheduling in the cloud environment that refers to sorting the workflow tasks on virtual machines on the cloud... 相似文献
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Mohammad Mahdi Najafpour Fahimeh Rahimi Davood Jafarian Sedigh Robert Carpentier Julian J. Eaton-Rye Jian-Ren Shen Suleyman I. Allakhverdiev 《Photosynthesis research》2013,117(1-3):423-429
In this report, gold or silver deposited on layered manganese oxide has been synthesized by a simple method and characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction spectrometry, atomic absorption spectroscopy, and energy-dispersive X-ray mapping. The gold deposited on layered manganese oxide showed efficient catalytic activity toward water oxidation in the presence of cerium(IV) ammonium nitrate. The properties associated with this compound suggest it is a functional model for the water-oxidizing complex in photosystem II. 相似文献