Effect of sevoflurane and halothane anesthesia on cognitive function and immune function in young rats

In the current study, we scrutinized the effect of sevoflurane and halothane on cognitive and immune function in young rats. The rats were divided into following groups: sevoflurane, halothane and sevoflurane + halothane groups, respectively. The rats were regularly treated with the pre-determined treatment. We also scrutinized the serum proinflammatory cytokines including IL-10, IL-4 and IL-2; brain level IL-1β; hippocampal neuronal apoptosis concentration were estimated. The water maze test was performed in rats for the estimation of cognitive ability. During the water maze test, on the 1st day the sevoflurane group showed the latency; sevoflurane and sevoflurane + halothane group demonstrated the declined latency gradually as compared to the control group rats after the 3 days. The latency of the control, halothane, sevoflurane + halothane group rats showed the reduced latency and also showed the reduced crossing circle times. The hippocampal neuron apoptosis was significantly increased in halothane and sevoflurane + halothane group as compared to control group rats, respectively. Control group rats demonstrated the increased neuron apoptosis. The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1β was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group. Sevoflurane can inhibit the anesthesia effect of halothane on the immune and cognitive function of rats.     

Associations of HSP90AA2 gene polymorphisms with disease susceptibility,glucocorticoids efficacy and health-related quality of life in Chinese systemic lupus erythematosus patients

Although the current glucocorticoids (GCs) treatment for systemic lupus erythematosus (SLE) is effective to a certain extent, the difference in therapeutic effect between patients is still a widespread problem. Some patients can have repeated attacks that greatly diminish their quality of life. This study was conducted to investigate the relationship between HSP90AA2 polymorphisms and disease susceptibility, GCs efficacy and health-related quality of life (HRQoL) in Chinese SLE patients. A case–control study was performed in 470 SLE patients and 470 normal controls. Then, 444 patients in the case group were followed up for 12 weeks to observe efficacy of GCs and improvement of HRQoL. Two single nucleotide polymorphisms (SNPs) of HSP90AA2 were selected for genotyping: rs1826330 and rs6484340. HRQoL was assessed using the SF-36 questionnaire. The minor T allele of rs1826330 and the TT haplotype formed by rs1826330 and rs6484340 showed associations with decreased SLE risk (T allele: P_BH?=?0.022; TT haplotype: P_BH?=?0.033). A significant association between rs6484340 and improvement of HRQoL was revealed in the follow-up study. Five subscales of SF-36 were appeared to be influenced by rs6484340: total score of SF-36 (additive model: P_BH?=?0.026), physical function (additive model: P_BH?=?0.026), role-physical (recessive model: P_BH?=?0.041), mental health (dominant model: P_BH?=?0.047), and physical component summary (additive model: P_BH?=?0.026). No statistical significance was found between HSP90AA2 gene polymorphisms and GCs efficacy. These results revealed a genetic association between HSP90AA2 and SLE. Remarkably, HSP90AA2 has an impact on the improvement of HRQoL in Chinese population with SLE.     

3′-半分子5′-末端双链结构阻止tRNA连接酶酶促反应

用定点突变技术将不同核苷酸引入酵母苯丙氨酸tRNA反密码子环32,37和38位.体外转录制备tRNA前体,其32,37和38位的核苷酸与野生型tRNA前体相应位点的核苷酸不同.用纯化的酵母tRNA内切酶和tRNA连接酶对这些tR-NA前体进行剪接加工.结果说明,这些位点的核苷酸不仅影响tRNA内切酶对tR-NA前体的酶切效率,而且3’-半分子5’-末端双链结构阻止tRNA连接酶将相应的tRNA半分子连接成整分子tRNA.     

植物叶片衰老与氧化胁迫

叶片衰老是叶片生长发育进程中的最后阶段,与活性氧伤害有着密切的关系。介绍了植物叶片衰老过程中活性氧产生及清除系统的变化,讨论了对水分胁迫与氧化胁迫的交叉抗性,并对下一步的研究作出了展望。     

The Major Types of Caryopses of the Chinese Gramineae in Relation to Systematics

Examinations were made on the morphology of caryopses of 324 grass species representing over 109 genera and 31 tribes. The evolutionary tendency of the important characteristics and the relation with distribution areas and habitats are discussed. According to the shape of caryopses, the morphology of ventral faces and hilum, the proportion of embryos to caryopses in size, the existence or absence of the top fine hairs, the persistence or shedding of styles, the size of fruits and especially the outline of the middle cross section, etc., the caryopses may be divided into three major types and seven subtypes: Bambusoid (including True Bambusoid, Arundinoid, Oryzoid, Stipoid), Panicoid (including True Panicoid, Eragrostoid) and Pooid (including the Subtype Pooid only). In this study, the different types of caryopses are found to be correlated with the characteristics of embryos, seedlings, habits and chromosomes, and on these grounds, the genera of the Gramineae are grouped into seven corresponding subfamilies: Bambusoideae, Oryzoideae, Arundinoideae, Stipoideae, Eragrostoideae, Panicoideae and Pooideae.     

Studies on Morphological Evolution,Classification and Distribution of the Triticeae in China

_{The classification and the relationships among the genera of Chinese Triticeae were studied based on morphological characters with reference to geographical distribution and habitat conditions. The spike of Triticeae might have been derived from a panicled inflorescence like that in the Bromeae through a racemose inflorescence like the one in the Brachypodieae. There might be three evolutionary lines in the tribe. 1. Pedicels of the panicled inflorescence have become short and bracts decreased in size, which has resulted in a panicled spike with indefinite spikelets or false solitary spikelets at each node of rachis. The middle ribes of both glumes and lemmas and rachilla are not in a single plane. 2. A simple spike with usual solitary spikelets at each node of rachis has been derived from the raceme. The middle ribe of both glumes and lemmas and rachilla are in a single plane. 3. A cymose spike with 3-spikelets at each node of rachis has evolved from the cymose panicle. The glume on the central spikelet is behind the lemma, while those on the lateral spikelets are on lateral sides of the lemmas. From what we have described above Triticeae may be divided into three subtribes: Elyminae, Triticinae and Hordeinae. Then according to the morphological characters of glume, lemma and other organs as well as the habitats and distribution, the native and introduced triticeous plants are classified into 13 genera (Leymus, Elymus, Roegneria, Elytrigia, Aegilops, Triticum, Agropyron, Eremopyrum, Secale, Haynaldia, Psathyrostachys, Hordeum and Hystrix) and their relationships are also discussed meanwhile.}