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141.
142.
Biological data is often tabular but finding statistically valid connections between entities in a sequence of tables can
be problematic - for example, connecting particular entities in a drug property table to gene properties in a second table,
using a third table associating genes with drugs. Here we present an approach (CRIT) to find connections such as these and
show how it can be applied in a variety of genomic contexts including chemogenomics data. 相似文献
143.
144.
Succinic acid, an intermediate of tricarboxylic acid cycle, is produced and accumulated by anaerobic microorganisms. The long-standing interest in the production of this organic acid is because it is a key compound in producing more than 30 commercially important products. The detection of succinic acid is generally carried out by gas chromatography (GC), enzymatic assays, ion-exclusion chromatography (IEC) or by high performance liquid chromatography (HPLC). However, these methods are time consuming, require sophisticated instrumentation and are expensive. In the present investigation we are reporting two rapid, cost effective screening methods for the detection of this important organic acid. These methods can be utilized to screen a large number of microbes producing succinic acid in a very short span of time. 相似文献
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146.
We describe a new therapeutic approach for the treatment of lethal sepsis using cell-penetrating lipopeptides-termed pepducins-that target either individual or multiple chemokine receptors. Interleukin-8 (IL-8), a ligand for the CXCR1 and CXCR2 receptors, is the most potent endogenous proinflammatory chemokine in sepsis. IL-8 levels rise in blood and lung fluids to activate neutrophils and other cells, and correlate with shock, lung injury and high mortality. We show that pepducins derived from either the i1 or i3 intracellular loops of CXCR1 and CXCR2 prevent the IL-8 response of both receptors and reverse the lethal sequelae of sepsis, including disseminated intravascular coagulation and multi-organ failure in mice. Conversely, pepducins selective for CXCR4 cause a massive leukocytosis that does not affect survival. CXCR1 and CXCR2 pepducins conferred nearly 100% survival even when treatment was postponed, suggesting that our approach might be beneficial in the setting of advanced disease. 相似文献
147.
Whole-proteome prediction of protein function via graph-theoretic analysis of interaction maps 总被引:2,自引:0,他引:2
Nabieva E Jim K Agarwal A Chazelle B Singh M 《Bioinformatics (Oxford, England)》2005,21(Z1):i302-i310
148.
Agarwal A Srivastava K Puri SK Sinha S Chauhan PM 《Bioorganic & medicinal chemistry letters》2005,15(23):5218-5221
A small library of 20 trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial and antitubercular activities. Out of the total screened compounds, 16 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25-2microg/mL and 8 compounds have shown antitubercular activity against Mycobacterium tuberculosis H(37)Ra, at a concentration of 12.5microg/mL. 相似文献
149.
Agarwal A Srivastava K Puri SK Chauhan PM 《Bioorganic & medicinal chemistry letters》2005,15(3):531-533
A series of 2,4,6-trisubstituted-1,3,5-triazines (2a-s) were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 19 compounds synthesized eight compounds showed MIC in the range of 1-2 microg/mL. These compounds are in vitro several times more active than cycloguanil. 相似文献
150.
Agarwal A Srivastava K Puri SK Sinha S Chauhan PM 《Bioorganic & medicinal chemistry letters》2005,15(22):4923-4926
A library of 30 trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial and antitubercular activity. Out of the 30 compounds synthesized, 23 compounds have shown in vitro antimalarial activity against Plasmodium falciparum in the range of 0.25-2 microg/mL and 16 compounds have shown antitubercular activity against Mycobacterium tuberculosis H37Ra, at a concentration of 25 microg/mL. 相似文献