全文获取类型
收费全文 | 702篇 |
免费 | 77篇 |
出版年
2021年 | 8篇 |
2019年 | 9篇 |
2018年 | 13篇 |
2017年 | 6篇 |
2016年 | 11篇 |
2015年 | 22篇 |
2014年 | 26篇 |
2013年 | 30篇 |
2012年 | 34篇 |
2011年 | 30篇 |
2010年 | 40篇 |
2009年 | 33篇 |
2008年 | 29篇 |
2007年 | 28篇 |
2006年 | 31篇 |
2005年 | 33篇 |
2004年 | 23篇 |
2003年 | 23篇 |
2002年 | 20篇 |
2001年 | 21篇 |
2000年 | 23篇 |
1999年 | 14篇 |
1998年 | 12篇 |
1997年 | 12篇 |
1996年 | 9篇 |
1995年 | 11篇 |
1994年 | 6篇 |
1993年 | 9篇 |
1992年 | 8篇 |
1991年 | 14篇 |
1990年 | 6篇 |
1989年 | 10篇 |
1988年 | 13篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1985年 | 7篇 |
1984年 | 7篇 |
1983年 | 8篇 |
1982年 | 23篇 |
1981年 | 8篇 |
1980年 | 7篇 |
1979年 | 11篇 |
1978年 | 9篇 |
1977年 | 14篇 |
1976年 | 12篇 |
1975年 | 7篇 |
1974年 | 4篇 |
1972年 | 7篇 |
1971年 | 7篇 |
1970年 | 3篇 |
排序方式: 共有779条查询结果,搜索用时 540 毫秒
101.
Jerry M. Baskin 《植被学杂志》2004,15(1):139-140
Book reviewed in this article: Delcourt, H.R. 2002. Forests in Peril: Tracking Deciduous Trees from Ice‐Age Refugia into the Greenhouse World. vii + 234 pp. The MacDonald and Woodward Publishing Company, Blacksburg, VA. ISBN 0–939923–89–0 (paper). Price: USD 22.95. 相似文献
102.
Judith van Holten Kris Reedquist Pascale Sattonet-Roche Tom JM Smeets Christine Plater-Zyberk Margriet J Vervoordeldonk Paul P Tak 《Arthritis research & therapy》2004,6(3):R239
We investigated the therapeutic potential and mechanism of action of IFN-β protein for the treatment of rheumatoid arthritis
(RA). Collagen-induced arthritis was induced in DBA/1 mice. At the first clinical sign of disease, mice were given daily injections
of recombinant mouse IFN-β or saline for 7 days. Disease progression was monitored by visual clinical scoring and measurement
of paw swelling. Inflammation and joint destruction were assessed histologically 8 days after the onset of arthritis. Proteoglycan
depletion was determined by safranin O staining. Expression of cytokines, receptor activator of NF-κB ligand, and c-Fos was
evaluated immunohistochemically. The IL-1-induced expression of IL-6, IL-8, and granulocyte/macrophage-colony-stimulating
factor (GM-CSF) was studied by ELISA in supernatant of RA and osteoarthritis fibroblast-like synoviocytes incubated with IFN-β.
We also examined the effect of IFN-β on NF-κB activity. IFN-β, at 0.25 μg/injection and higher, significantly reduced disease
severity in two experiments, each using 8–10 mice per treatment group. IFN-β-treated animals displayed significantly less
cartilage and bone destruction than controls, paralleled by a decreased number of positive cells of two gene products required
for osteoclastogenesis, receptor activator of NF-κB ligand and c-Fos. Tumor necrosis factor α and IL-6 expression were significantly
reduced, while IL-10 production was increased after IFN-β treatment. IFN-β reduced expression of IL-6, IL-8, and GM-CSF in
RA and osteoarthritis fibroblast-like synoviocytes, correlating with reduced NF-κB activity. The data support the view that
IFN-β is a potential therapy for RA that might help to diminish both joint inflammation and destruction by cytokine modulation. 相似文献
103.
104.
105.
106.
The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75. These autoantigens have been reported to associate into a large complex consisting of 11 to 16 proteins and to play a role in ribosome synthesis. Recently, it was discovered that the PM/Scl complex is the human counterpart of the yeast (Saccharomyces cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3' → 5' exoribonucleases. To date, 10 human exosome components have been identified, although only some of these were studied in more detail. In this review, we discuss some recent advances in the characterization of the PM/Scl complex. 相似文献
107.
On the alignment of cellulose microfibrils by cortical microtubules: A review and a model 总被引:34,自引:0,他引:34
Tobias I. Baskin 《Protoplasma》2001,215(1-4):150-171
Summary The hypothesis that microtubules align microfibrils, termed the alignment hypothesis, states that there is a causal link between the orientation of cortical microtubules and the orientation of nascent microfibrils. I have assessed the generality of this hypothesis by reviewing what is known about the relation between microtubules and microfibrils in a wide group of examples: in algae of the family Characeae,Closterium acerosum, Oocystis solitaria, and certain genera of green coenocytes and in land plant tip-growing cells, xylem, diffusely growing cells, and protoplasts. The salient features about microfibril alignment to emerge are as follows. Cellulose microfibrils can be aligned by cortical microtubules, thus supporting the alignment hypothesis. Alignment of microfibrils can occur independently of microtubules, showing that an alternative to the alignment hypothesis must exist. Microfibril organization is often random, suggesting that self-assembly is insufficient. Microfibril organization differs on different faces of the same cell, suggesting that microfibrils are aligned locally, not with respect to the entire cell. Nascent microfibrils appear to associate tightly with the plasma membrane. To account for these observations, I present a model that posits alignment to be mediated through binding the nascent microfibril. The model, termed templated incorporation, postulates that the nascent microfibril is incorporated into the cell wall by binding to a scaffold that is oriented; further, the scaffold is built and oriented around either already incorporated microfibrils or plasma membrane proteins, or both. The role of cortical microtubules is to bind and orient components of the scaffold at the plasma membrane. In this way, spatial information to align the microfibrils may come from either the cell wall or the cell interior, and microfibril alignment with and without microtubules are subsets of a single mechanism.Dedicated to Professor Brian E. S. Gunning on the occasion of his 65th birthday 相似文献
108.
109.
110.