全文获取类型
收费全文 | 222篇 |
免费 | 23篇 |
出版年
2022年 | 2篇 |
2021年 | 7篇 |
2019年 | 2篇 |
2018年 | 4篇 |
2017年 | 7篇 |
2016年 | 4篇 |
2015年 | 13篇 |
2014年 | 9篇 |
2013年 | 19篇 |
2012年 | 16篇 |
2011年 | 13篇 |
2010年 | 6篇 |
2009年 | 9篇 |
2008年 | 7篇 |
2007年 | 4篇 |
2006年 | 6篇 |
2005年 | 4篇 |
2004年 | 4篇 |
2003年 | 2篇 |
2002年 | 2篇 |
2001年 | 4篇 |
2000年 | 2篇 |
1999年 | 6篇 |
1998年 | 8篇 |
1997年 | 6篇 |
1996年 | 5篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 5篇 |
1992年 | 2篇 |
1991年 | 8篇 |
1990年 | 5篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 4篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 5篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有245条查询结果,搜索用时 15 毫秒
21.
Genetic determination and linkage mapping of Plasmodium falciparum malaria related traits in Senegal
Sakuntabhai A Ndiaye R Casadémont I Peerapittayamongkol C Peerapittayamonkol C Rogier C Tortevoye P Tall A Paul R Turbpaiboon C Phimpraphi W Trape JF Spiegel A Heath S Mercereau-Puijalon O Dieye A Julier C 《PloS one》2008,3(4):e2000
Plasmodium falciparum malaria episodes may vary considerably in their severity and clinical manifestations. There is good evidence that host genetic factors contribute to this variability. To date, most genetic studies aiming at the identification of these genes have used a case/control study design for severe malaria, exploring specific candidate genes. Here, we performed a family-based genetic study of falciparum malaria related phenotypes in two independent longitudinal survey cohorts, as a first step towards the identification of genes and mechanisms involved in the outcome of infection. We studied two Senegalese villages, Dielmo and Ndiop that differ in ethnicity, malaria transmission and endemicity. We performed genome-scan linkage analysis of several malaria-related phenotypes both during clinical attacks and asymptomatic infection. We show evidence for a strong genetic contribution to both the number of clinical falciparum malaria attacks and the asymptomatic parasite density. The asymptomatic parasite density showed linkage to chromosome 5q31 (LOD = 2.26, empirical p = 0.0014, Dielmo), confirming previous findings in other studies. Suggestive linkage values were also obtained at three additional chromosome regions: the number of clinical malaria attacks on chromosome 5p15 (LOD = 2.57, empirical p = 0.001, Dielmo) and 13q13 (LOD = 2.37, empirical p = 0.0014 Dielmo), and the maximum parasite density during asymptomatic infection on chromosome 12q21 (LOD = 3.1, empirical p<10(-4), Ndiop). While regions of linkage show little overlap with genes known to be involved in severe malaria, the four regions appear to overlap with regions linked to asthma or atopy related traits, suggesting that common immune related pathways may be involved. 相似文献
22.
23.
24.
Plant and Soil - Soil-feeding termite mounds are an important, highly specific soil microbial compartment in semi-arid savannas. The aim of this study was to determine the role of these mounds in... 相似文献
25.
Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. 总被引:16,自引:0,他引:16
Arnaud André Mailleux Bradley Spencer-Dene Christian Dillon Delphine Ndiaye Catherine Savona-Baron Nobuyuki Itoh Shigeaki Kato Clive Dickson Jean Paul Thiery Saverio Bellusci 《Development (Cambridge, England)》2002,129(1):53-60
The mouse develops five pairs of mammary glands that arise during mid-gestation from five pairs of placodes of ectodermal origin. We have investigated the molecular mechanisms of mammary placode development using Lef1 as a marker for the epithelial component of the placode, and mice deficient for Fgf10 or Fgfr2b, both of which fail to develop normal mammary glands. Mammary placode induction involves two different signaling pathways, a FGF10/FGFR2b-dependent pathway for placodes 1, 2, 3 and 5 and a FGF10/FGFR2b-independent pathway for placode 4. Our results also suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor. 相似文献
26.
27.
We consider metabolic networks with reversible enzymatic reactions. The model is written as a system of ordinary differential equations, possibly with inputs and outputs. We prove the global stability of the equilibrium (if it exists), using techniques of monotone systems and compartmental matrices. We show that the equilibrium does not always exist. Finally, we consider a metabolic system coupled with a genetic network, and we study the dependence of the metabolic equilibrium (if it exists) with respect to concentrations of enzymes. We give some conclusions concerning the dynamical behavior of coupled genetic/metabolic systems. 相似文献
28.
29.
30.
Methodological improvements now allow routine analyses of highly degraded DNA samples as found in museum specimens. Using these methods could be useful in studying such groups as rodents of the genus Gerbillus for which i) the taxonomy is still highly debated, ii) collection of fresh specimens may prove difficult. Here we address precise taxonomic questions using a small portion of the cytochrome b gene obtained from 45 dry skin/skull museum samples (from 1913 to 1974) originating from two African and three Asian countries. The specimens were labelled Gerbillus
gerbillus, Gerbillus
andersoni, Gerbillus
nanus, Gerbillus
amoenus, Gerbillus
perpallidus and Gerbillus
pyramidum, and molecular results mostly confirmed these assignations. The close relationship between Gerbillus
nanus (Asian origin) and Gerbillus
amoenus (African origin) confirmed that they represent vicariant sibling species which differentiated in allopatry on either side of the Red Sea. In the closely related Gerbillus
perpallidus and Gerbillus
pyramidum, specimens considered as belonging to one Gerbillus
pyramidum subspecies (Gerbillus
pyramidum
floweri) appeared closer to Gerbillus
perpallidus suggesting that they (Gerbillus
pyramidum
floweri and Gerbillus
perpallidus) may represent a unique species, distributed on both sides of the Nile River, for which the correct name should be Gerbillus
floweri. Furthermore, the three other Gerbillus
pyramidum subspecies grouped together with no apparent genetic structure suggesting that they may not yet represent genetically differentiated lineages. This study confirms the importance of using these methods on museum samples, which can open new perspectives in this particular group as well as in other groups of interest. 相似文献