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121.
Krishanu Mukherjee Everly Conway de Macario Alberto JL Macario Luciano Brocchieri 《BMC evolutionary biology》2010,10(1):64
Background
Chaperonin proteins are well known for the critical role they play in protein folding and in disease. However, the recent identification of three diverged chaperonin paralogs associated with the human Bardet-Biedl and McKusick-Kaufman Syndromes (BBS and MKKS, respectively) indicates that the eukaryotic chaperonin-gene family is larger and more differentiated than previously thought. The availability of complete genome sequences makes possible a definitive characterization of the complete set of chaperonin sequences in human and other species. 相似文献122.
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Combining protein evolution and secondary structure 总被引:10,自引:9,他引:10
An evolutionary model that combines protein secondary structure and amino
acid replacement is introduced. It allows likelihood analysis of aligned
protein sequences and does not require the underlying secondary (or
tertiary) structures of these sequences to be known. One component of the
model describes the organization of secondary structure along a protein
sequence and another specifies the evolutionary process for each category
of secondary structure. A database of proteins with known secondary
structures is used to estimate model parameters representing these two
components. Phylogeny, the third component of the model, can be estimated
from the data set of interest. As an example, we employ our model to
analyze a set of sucrose synthase sequences. For the evolution of sucrose
synthase, a parametric bootstrap approach indicates that our model is
statistically preferable to one that ignores secondary structure.
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I Saltvedt A Prestmo E Einarsen LG Johnsen JL Helbostad O Sletvold 《BMC research notes》2012,5(1):355
ABSTRACT: BACKGROUND: Hip fractures are common among frail elderly persons and often have serious consequences on function, mobility and mortality. Traditional treatment of these patients is performed in orthopedic departments without additional geriatric assessment. However, studies have shown that interdisciplinary geriatric treatment may be beneficial compared to traditional treatment. The aim of the present study is to investigate whether treatment of these patients in a Department of Geriatrics (DG) during the entire hospital stay gives additional benefits as compared to conventional treatment in a Department of Orthopaedic Surgery (DOS). FINDINGS: A new clinical pathway for in-hospital treatment of hip fracture patients was developed. In this pathway patients were treated pre-and postoperatively in DG. Comprehensive geriatric assessment was performed as an interdisciplinary, multidimensional, systematic assessment of all patients focusing on each patient's capabilities and limitations as recommended in guidelines and systematic reviews. Identification and treatment of co-morbidities, pain relief, hydration, oxygenation, nutrition, elimination, prevention and management of delirium, assessment of falls and osteoporosis were emphasized. Discharge planning started as early as possible. Initiation of rehabilitation with focus on early mobilisation and development of individual plans was initiated in hospital and continued after discharge from hospital. Fracture specific treatment was based upon standard treatment for the hospital, expert opinions and a review of the literature. CONCLUSION: A new treatment program for old hip fracture patients was developed, introduced and run in the DG, the potential benefits of which being compared with traditional care of hip fracture patients in the DOS in a randomised clinical trial. 相似文献