全文获取类型
收费全文 | 789篇 |
免费 | 100篇 |
出版年
2020年 | 7篇 |
2019年 | 14篇 |
2018年 | 8篇 |
2017年 | 12篇 |
2016年 | 10篇 |
2015年 | 26篇 |
2014年 | 26篇 |
2013年 | 36篇 |
2012年 | 52篇 |
2011年 | 50篇 |
2010年 | 19篇 |
2009年 | 24篇 |
2008年 | 23篇 |
2007年 | 37篇 |
2006年 | 27篇 |
2005年 | 23篇 |
2004年 | 28篇 |
2003年 | 21篇 |
2002年 | 23篇 |
2001年 | 26篇 |
2000年 | 29篇 |
1999年 | 18篇 |
1998年 | 15篇 |
1997年 | 13篇 |
1996年 | 10篇 |
1995年 | 12篇 |
1994年 | 15篇 |
1993年 | 7篇 |
1992年 | 17篇 |
1991年 | 12篇 |
1990年 | 9篇 |
1989年 | 12篇 |
1988年 | 12篇 |
1987年 | 10篇 |
1986年 | 11篇 |
1985年 | 10篇 |
1983年 | 7篇 |
1981年 | 7篇 |
1980年 | 12篇 |
1979年 | 13篇 |
1978年 | 15篇 |
1977年 | 9篇 |
1976年 | 5篇 |
1975年 | 9篇 |
1974年 | 7篇 |
1973年 | 11篇 |
1972年 | 10篇 |
1971年 | 6篇 |
1969年 | 12篇 |
1966年 | 9篇 |
排序方式: 共有889条查询结果,搜索用时 828 毫秒
111.
Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones. 总被引:4,自引:0,他引:4
Helen F Boyd Stephen C M Fell Deirdre M B Hickey Robert J Ife Colin A Leach Colin H Macphee Kevin J Milliner Ivan L Pinto D Anthony Rawlings Stephen A Smith Ian G Stansfield Steven J Stanway Colin J Theobald Caroline M Whittaker 《Bioorganic & medicinal chemistry letters》2002,12(1):51-55
A series of 1-(biphenylmethylamidoalkyl)-pyrimidones has been designed as nanomolar inhibitors of recombinant lipoprotein-associated phospholipase A(2) with high potency in whole human plasma. 5-(Pyrazolylmethyl) derivative 16 and 5-(methoxypyrimidinylmethyl) derivative 27 demonstrated excellent pharmacodynamic profiles which correlated well with their pharmacokinetic effects. 相似文献
112.
113.
114.
115.
116.
117.
Lopa Leach Bryan M. Eaton J. Anthony Firth Dr. Soli F. Contractor 《Cell and tissue research》1989,257(3):603-607
Summary Endogenous immunoglobulin-G was localised in ultrathin frozen sections of human term placenta by use of an indirect immuno electron-histochemical methodology. Immunoreactivity of endogenous IgG to rabbit anti-human immunoglobulin-G antibody was visualised by use of protein-A — colloidal gold complex. Gold marked the syncytiotrophoblast in both coated and uncoated regions of the apical plasmalemma, in vesicles and multivesicular bodies, and in vesicles near the basal plasmalemma. Immunoreactivity was also seen in the interstitial space between the trophoblast and the fetal endothelial layer as well as in various types of vesicles within the endothelial cells. No immunoreactivity was seen in the intercellular clefts of the endothelium. The pattern of localisation observed is consistent with receptor-mediated uptake of immunoglobulin-G into the syncytiotrophoblast of the human placenta followed by release into the interstitial space and then vesciular transport through the endothelium. 相似文献
118.
119.
120.
Routine neurological examination of patients one hour after cardiac arrest seems to be of value in determining the prognosis for life and likelihood of intellectual impairment.In 48 patients 53 episodes of cardiac arrest were followed by serial neurological examinations. Patients were divided into two groups according to neurological findings one hour after cardiac arrest. Patients in group 1 were unresponsive or at most responded in a reflex fashion to painful stimuli at one hour; these patients died or survived with intellectual damage. Patients in group 2 responded purposefully at one hour and survived without neurological damage. These patients commonly showed transient confusional states and a variety of other non-focal abnormalities, and focal signs were seen occasionally. 相似文献