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Presotto Andréa Remillard Caren Spagnoletti Noemi Salmi Roberta Verderane Michele Stafford Kathleen dos Santos Ricardo Rodrigues Madden Marguerite Fragaszy Dorothy Visalberghi Elisabetta Izar Patrícia 《International journal of primatology》2020,41(4):596-613
International Journal of Primatology - Animal traditions are increasingly threatened by human impact on natural habitats, posing a challenge to conservation policies. In northeastern Brazil,... 相似文献
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Simone P. Barbosa Lívia C. Lins Francisco A. Fonseca Lívia N. Matos Ana C. Aguirre Henrique T. Bianco Jonatas B. Amaral Carolina N. França Jose M. Santana Maria C. Izar 《Life sciences》2013,92(14-16):845-851
AimsHigh-risk subjects with elevated C-reactive protein (CRP) are at high risk for cardiovascular events and frequently require potent statins or combined lipid-lowering therapy to achieve lipid targets and decrease inflammation. Our study aimed at evaluating the effects of three lipid-modifying therapies on LDL-cholesterol, CRP levels and markers of cholesterol absorption and synthesis.Main methodsA prospective intervention study was performed in high cardiovascular risk individuals receiving atorvastatin 10 mg daily for four weeks. Those with CRP ≥ 2.0 mg/L were randomized to another four-week treatment period with atorvastatin 40 mg, ezetimibe 10 mg or the combination of atorvastatin 40 mg / ezetimibe 10 mg. Lipids, markers of cholesterol absorption (campesterol and β-sitosterol), and synthesis (desmosterol), as well as CRP were quantified at baseline and end of study.Key findingsOne hundred and twenty two individuals were included. Atorvastatin alone or combined with ezetimibe reduced both LDL-cholesterol and CRP (P < 0.002 vs. baseline; Wilcoxon); ezetimibe did not modify CRP. Ezetimibe-based therapies reduced absorption markers and their ratios to cholesterol (P < 0.0001 vs. baseline, for all; Wilcoxon), whereas atorvastatin alone increased campesterol/cholesterol and β-sitosterol/cholesterol ratios (P < 0.05 vs. baseline; Wilcoxon). In addition, ezetimibe also increased desmosterol and desmosterol/cholesterol ratio (P < 0.0001 vs. baseline; Wilcoxon).SignificanceThese results contribute to understanding the link between cellular cholesterol homeostasis, inflammation and lipid-modifying therapies. Our findings highlight the broader benefit of combined therapy with a potent statin and ezetimibe decreasing inflammation, and preventing increase in cholesterol biosynthesis, an effect not observed with ezetimibe alone. 相似文献
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Henrique Andrade R. Fonseca Francisco A. Fonseca Andrea M. Monteiro Henrique T. Bianco Paulo Boschcov Sergio A. Brandão Luiz Juliano Magnus Gidlund Maria C. Izar 《Cell biochemistry and biophysics》2013,67(3):1451-1460
Obesity and hypertension have been recognized as inflammatory diseases capable of activating the immune system, thus contributing to an increased cardiovascular risk. However, the link between adaptive immunity, obesity, and hypertension is poorly understood. We investigated the relationship of the body mass index (BMI) on the inflammatory, vascular, and immune responses in patients with hypertension naïve of anti-hypertensive treatment. Hypertensive patients (N = 88) were divided into three groups: normal weight (NW), overweight (OW), and obese (OB) subjects. Anti-oxidized LDL autoantibodies (anti-oxLDL Abs), anti-ApoB-D peptide (anti-ApoB-D) Abs, interleukin (IL)-8 and IL-10, flow-mediated dilation (FMD) of the brachial artery, and 24-h ambulatory blood pressure monitoring (ABPM) were assessed. OB patients presented lower levels of anti-oxLDL Abs and IL-10, higher levels of IL-8, and impaired FMD, when compared to NW and OW (P < 0.05), without differences between groups regarding anti-ApoB-D Abs. After adjusting for age, systolic and diastolic blood pressure, anti-oxLDL Abs were inversely correlated with BMI and waist circumference (r = ?0.24, P = 0.02 and r = ?0.25, P = 0.02, respectively), whereas ApoB-D correlated with 24-h ABPM (r = 0.22, P = 0.05 for systolic, and r = 0.29, P = 0.01 for diastolic blood pressure). Regression analyses showed inverse associations of anti-oxLDL Abs with BMI (β = ?0.05, P = 0.01) and waist circumference (β = ?0.01, P = 0.02); anti-ApoB-D Abs were associated with systolic and diastolic 24-h ABPM (β = 0.96, P = 0.04; β = 1.02, P = 0.005, for systolic and diastolic 24-h ABPM, respectively). Among hypertensive patients, obesity modulates the immune and inflammatory milieu, determining an unfavorable balance of cytokines and reduction in titers of anti-oxLDL Abs. Twenty-four hour ABPM is associated with titers of anti-ApoB-D Abs. 相似文献
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Alfaro JW Matthews L Boyette AH Macfarlan SJ Phillips KA Falótico T Ottoni E Verderane M Izar P Schulte M Melin A Fedigan L Janson C Alfaro ME 《American journal of primatology》2012,74(4):299-314
The frequency of anointing bouts and the materials used for self- and social anointing vary across capuchin species in captivity, but there is little published data on capuchin anointing in the wild. Here we present previously unpublished data on anointing behaviors from capuchin monkey populations at ten different field sites and incorporate these data into a review of the anointing literature for captive and wild capuchins. Using a comparative phylogenetic framework, we test four hypotheses derived primarily from captive literature for variation in anointing between wild untufted capuchins (Cebus) and tufted capuchins (Sapajus), including that (1) the frequency of anointing is higher in Cebus, (2) Cebus uses a higher proportion of plant species to insect species for anointing compared with Sapajus, (3) anointing material diversity is higher in Cebus, and (4) social indices of anointing are higher in Cebus. We found that wild Cebus anoints more with plant parts, including fruits, whereas wild Sapajus anoints more with ants and other arthropods. Cebus capucinus in particular uses more plant species per site for anointing compared with other capuchins and may specialize in anointing as an activity independent from foraging, whereas most other capuchin species tend to eat the substances they use for anointing. In agreement with captive studies, we found evidence that wild Cebus anoints at a significantly higher frequency than Sapajus. However, contrary to the captive literature, we found no difference in the range of sociality for anointing between Cebus and Sapajus in the wild. We review anointing in the context of other Neotropical primate rubbing behaviors and consider the evidence for anointing as self-medication; as a mechanism for enhanced sociality; and as a behavioral response to chemical stimuli. 相似文献
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Izar P Verderane MP Peternelli-Dos-Santos L Mendonça-Furtado O Presotto A Tokuda M Visalberghi E Fragaszy D 《American journal of primatology》2012,74(4):315-331
Socioecological models assume that primates adapt their social behavior to ecological conditions, and predict that food availability and distribution, predation risk and risk of infanticide by males affect patterns of social organization, social structure and mating system of primates. However, adaptability and variation of social behavior may be constrained by conservative adaptations and by phylogenetic inertia. The comparative study of closely related species can help to identify the relative contribution of ecological and of genetic determinants to primate social systems. We compared ecological features and social behavior of two species of the genus Sapajus, S. nigritus in Carlos Botelho State Park, an area of Atlantic Forest in S?o Paulo state, and S. libidinosus in Fazenda Boa Vista, a semi-arid habitat in Piauí state, Brazil. S. libidinosus perceived higher predation risk and fed on clumped, high quality, and usurpable resources (fruits) all year round, whereas S. nigritus perceived lower predation risk and relied on evenly distributed, low-quality food sources (leaves) during periods of fruit shortage. As predicted by socioecology models, S. libidinosus females were philopatric and established linear and stable dominance hierarchies, coalitions, and grooming relationships. S. nigritus females competed less often, and could transfer between groups, which might explain the lack of coalitions and grooming bonds among them. Both populations presented similar group size and composition and the same polygynous mating system. The species differed from each other in accordance with differences in the characteristics of their main food sources, as predicted by socioecological models, suggesting that phylogenetic inertia does not constrain social relationships established among female Sapajus. The similarity in mating systems indicates that this element of the social system is not affected by ecological variables and thus, is a more conservative behavioral feature of the genus Sapajus. 相似文献
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Noemi Spagnoletti Tadeu Campioni Morone Cardoso Dorothy Fragaszy Patrícia Izar 《International journal of primatology》2017,38(2):243-262
Foraging on anthropogenic food by wildlife is a prevalent form of human–wildlife interaction. Few studies have evaluated the impact of wildlife crop foraging in Neotropical areas where small-scale agriculture is practiced and the habitat has not been heavily altered. Our objectives were 1) to evaluate the perceptions of small-scale farmers living in southern Piauí (Brazil) of the impact of bearded capuchins (Sapajus libidinosus) on their crops and 2) quantify crop losses due to the monkeys and other vertebrates. In 2013, we interviewed 78 residents about the impact of capuchins on their crops. Subsequently, we recorded foraging by vertebrate animals in corn fields, and evaluated farmers’ crop losses. The farmers showed a positive attitude toward the capuchins and their perceptions of wildlife behavior were generally accurate. The impact of wildlife varied in relation to the field’s location, number of foraging individuals, and time spent foraging, as well as plant growth patterns. Vertebrates consumed between 23 and 100 % of the crops. Capuchins consumed the majority of crop losses, though birds consumed up to a third. The presence of a watchman reduced losses from wildlife by 66 %. In conclusion, although capuchins forage flexibly on anthropogenic crops, in a society relying on subsistence agriculture, their impact is perceived to be moderate overall. Peaceful coexistence between humans and monkeys favors conservation actions targeted toward protection of the capuchins and their habitat, both of which are seriously threatened by industrial agriculture in this region. 相似文献
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Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state
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Priscila Suscke Michele Verderane Robson Santos de Oliveira Irene Delval Marcelo Fernández-Bolaños Patrícia Izar 《Primates; journal of primatology》2017,58(1):141-147
We describe seven encounters between different harpy eagle individuals (Harpia harpyja) and a group of yellow-breasted capuchin monkeys (Sapajus xanthosternos) in Una Biological Reserve. These interactions lasted 58 min on average. In each of those encounters, the capuchin monkeys used particular behavioral strategies against the harpy eagle that were not employed in reaction to other aerial predators. We did not observe any successful predation events, but after one of those encounters an infant disappeared from the capuchin group. As a whole, these observations indicate that the presence of harpy eagles in the group’s home range increases predation risk for capuchin monkeys. The present report also suggests a reoccupation by H. harpyja of this area, as no previous recent records identify harpy eagle occurrence in Una Biological Reserve. 相似文献
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