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51.
Shigehiro Namiki Satoshi Iwabuchi Ryohei Kanzaki 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》2008,194(5):501-515
Pheromone-source orientation behavior can be modified by coexisting plant volatiles. Some host plant volatiles enhance the
pheromonal responses of olfactory receptor neurons and increase the sensitivity of orientation behavior in the Lepidoptera
species. Although many electrophysiological studies have focused on the pheromonal response of olfactory interneurons, the
response to the mixture of pheromone and plant odor is not yet known. Using the silkmoth, Bombyx mori, we investigated the physiology of interneurons in the antennal lobe (AL), the primary olfactory center in the insect brain,
in response to a mixture of the primary pheromone component bombykol and cis-3-hexen-1-ol, a mulberry leaf volatile. Application of the mixture enhanced the pheromonal responses of projection neurons
innervating the macroglomerular complex in the AL. In contrast, the mixture of pheromone and cis-3-hexen-1-ol had little influence on the responses of projection neurons innervating the ordinary glomeruli whereas other
plant odors dynamically modified the response. Together this suggests moths can process plant odor information under conditions
of simultaneous exposure to sex pheromone. 相似文献
52.
53.
C Katsume G Fernandes K Iwabuchi K Ogasawara T Gotohda R A Good K Onoé 《Microbiology and immunology》1989,33(4):313-328
Early development of T lineage cells were compared between AKR and C3H mice by using two experimental strategies--neonatal thymectomy (NTx) and bone marrow transplantation (BMT)--between these two strains of mice. After NTx, AKR mice developed less wasting disease and showed better maintenance of several T cell functions. In addition, the response of neonatal spleen cells to PHA and ConA was much greater in AKR mice than in C3H mice. Further, when AKR mice were used as recipients of BMT, cell numbers recovered from thymuses between 2 and 7 weeks after reconstitution were consistently much greater (about 10 times greater) than those from chimeras where C3H mice were used as recipients, regardless of the donor strains of bone marrow cells. However, 4 weeks after BMT the proliferative responses to ConA were consistently higher in the donor-derived thymocytes from chimeras where AKR mice were used as bone marrow donors than in those from chimeras in which C3H were donors. The present findings suggest that these differences may be attributed to characteristics of recipient microenvironment (e.g., thymic stroma) which maintain developing thymocytes and supply them to the peripheral lymphoid tissue. Alternatively the differences may to some degree also be attributable to characteristics of the thymic progenitors themselves, which may determine the rates of maturation of thymocyte functions. 相似文献
54.
Tomohei Nakao Hiroko Fukushima Takashi Fukushima Ryoko Suzuki Sho Hosaka Yuni Yamaki Chie Kobayashi Atsushi Iwabuchi Kazuo Imagawa Aiko Sakai Toko Shinkai Kouji Masumoto Shingo Sakashita Tomohiko Masumoto Masashi Mizumoto Ryo Sumazaki Hideyuki Sakurai 《Reports of Practical Oncology and Radiotherapy》2018,23(5):442-450
Aim
To assess the feasibility of transferring to the University of Tsukuba Hospital for proton beam therapy (PBT) during intensive chemotherapy in children with Ewing sarcoma family of tumors (ESFT) who had been diagnosed and started their first-line treatment at prefectural or regional centers for pediatric oncology.Background
The treatment of ESFT relies on a multidisciplinary approach using intensive neoadjuvant and adjuvant chemotherapies with surgery and radiotherapy. Multi-agent chemotherapy comprising vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide (VDC-IE) is widely used for ESFT, and the interval between each course is very important for maintaining the intensity and effect of chemotherapy.Materials and methods
Clinical information of patients who received PBT and VDC-IE between April 2009 and May 2016 was collected retrospectively. The intervals between each course of VDC-IE and adverse events were assessed.Results
Fifteen patients were evaluated. No delays in the intervals of chemotherapy due to transfer were observed. There were no adverse events caused during/just after transfer and no increases in adverse events. The estimated 4-year overall and event-free survival rates were 94.6% and 84.8%, respectively.Discussion
Although the results of efficacy are preliminary, survival rates were comparable with past studies. More experience and follow-up are required to further assess the efficacy of PBT for patients with ESFT.Conclusion
Multidisciplinary therapy for children with ESFT involving transfer to our hospital for PBT during VDC-IE was feasible without treatment delay or an increase in adverse events. 相似文献55.
56.
Teiji Takechi Katsuhisa Koizumi Atsushi Azuma Masakazu Fukushima Katsutoshi Kobayashi Shinya Oda Katsuhiko Yanaga Leon Mullenders Peter Karran Masatsugu Ueda Yoshito Terai Minoru Ueki Masaru Sakamoto Aako Kondo Kiyohiko Miyake Yauko Koyamatsu Tsukasa Akiya Makoto Nakano Hiroshi Iwabuchi Tetsuya Muroya Yoshio Tenjin Kazunori Ochiai Tadao Tanaka Kyosuke Ymada Kazu Ueda Akihiko Misawa Aikou Okamoto Eizo Kimura Makoto Yasuda 《Human cell》2004,17(2):16-21
57.
R Ohwatari K Iwabuchi C Iwabuchi T Morohashi H Sawa K Hioki K Kobayashi S Fukuda Y Inuyama K Onoé 《Cellular immunology》2001,213(1):24-33
Using a class-I-restricted T cell receptor (TCR) transgenic mice (Tgm), 2C (Valpha3.1/Vbeta 8.2, specific for L(d) + LSPFPFDL), the development and cytokine production of tg-TCR(+) NKT cells were analyzed. We found that CD8(+) or double negative (DN) NKT cells constituted a major population of NKT cells in the H-2(b/b) 2C Tgm (positive selecting background) or the H-2(b/d) 2C Tgm (negative selecting background), respectively. Virtually no NKT cells were generated in the H-2(k/k) 2C Tgm (neutral selecting background). CD8(+) NKT cells in the H-2(b/b) 2C Tgm expressed CD8alphabeta heterodimers, whereas those in the H-2(b/d) 2C Tgm expressed CD8alphaalpha homodimers. These findings suggest that development of a subpopulation of NKT cells is influenced by the H-2 molecules. Upon stimulation with anti-CD3 mAb, tg-TCR(+) NKT cells generated in the H-2(b/b) and H-2(b/d) backgrounds produced IFN-gamma, but not IL-4. 相似文献
58.
59.
Segregative cell division and the cytoskeleton in two species of the genus Struvea (Cladophorales,Ulvophyceae, Chlorophyta)
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Kazuo Okuda Satoko Sekida Ami Hasebe Misa Iwabuchi Mitsunobu Kamiya Tasuku Hishinuma 《Phycological Research》2016,64(4):219-229
The detailed segregative cell division (SCD) processes and changes in the arrangement of cortical microtubules and actin filaments were examined in two species of Struvea. SCD was initiated by the appearance of annular constrictions along the lateral side of a mother cell. The constrictions decreased in diameter, became thin, tubular in shape, and pinched the protoplasm of the mother cell into several protoplasmic sections. The protoplasmic sections expanded and developed into daughter cells, which appressed each other, and were arranged in a single row. Lateral branches protruded from the upper parts of the daughter cells. The protoplasm of the lateral branches was divided by secondary SCDs and was distributed amongst the new daughter cells. SCD and lateral branch formation were essential for morphogenesis in Struvea. Cortical microtubules were arranged parallel and longitudinally to the cell axis before SCD. When SCD was initiated, there was considerable undulation of the cortical microtubules and several transverse bundles appeared in the cytoplasmic zone where annular constrictions occurred. A microtubule‐disrupting drug (amiprophos methyl) inhibited SCD. Actin filaments maintained reticulate patterns before and during SCD. These results demonstrated that SCD in Struvea species was quite distinct from that in Dictyosphaeria cavernosa reported previously. 相似文献
60.