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941.
Yinghong Hu Eline M. Hutter Philipp Rieder Irene Grill Jonas Hanisch Meltem F. Aygüler Alexander G. Hufnagel Matthias Handloser Thomas Bein Achim Hartschuh Kristofer Tvingstedt Vladimir Dyakonov Andreas Baumann Tom J. Savenije Michiel L. Petrus Pablo Docampo 《Liver Transplantation》2018,8(16)
Adding cesium (Cs) and rubidium (Rb) cations to FA0.83MA0.17Pb(I0.83Br0.17)3 hybrid lead halide perovskites results in a remarkable improvement in solar cell performance, but the origin of the enhancement has not been fully understood yet. In this work, time‐of‐flight, time‐resolved microwave conductivity, and thermally stimulated current measurements are performed to elucidate the impact of the inorganic cation additives on the trap landscape and charge transport properties within perovskite solar cells. These complementary techniques allow for the assessment of both local features within the perovskite crystals and macroscopic properties of films and full devices. Strikingly, Cs‐incorporation is shown to reduce the trap density and charge recombination rates in the perovskite layer. This is consistent with the significant improvements in the open‐circuit voltage and fill factor of Cs‐containing devices. By comparison, Rb‐addition results in an increased charge carrier mobility, which is accompanied by a minor increase in device efficiency and reduced current–voltage hysteresis. By mixing Cs and Rb in quadruple cation (Cs‐Rb‐FA‐MA) perovskites, the advantages of both inorganic cations can be combined. This study provides valuable insights into the role of these additives in multiple‐cation perovskite solar cells, which are essential for the design of high‐performance devices. 相似文献
942.
Perovskite Solar Cells: Understanding the Role of Cesium and Rubidium Additives in Perovskite Solar Cells: Trap States,Charge Transport,and Recombination (Adv. Energy Mater. 16/2018) 下载免费PDF全文
943.
Floral antagonists counteract pollinator‐mediated selection on attractiveness traits in the hummingbird‐pollinated Collaea cipoensis (Fabaceae) 下载免费PDF全文
Irene Gélvez‐Zúñiga Alberto L. Teixido Ana C. O. Neves Geraldo Wilson Fernandes 《Biotropica》2018,50(5):797-804
Pollinator‐mediated selection toward larger and abundant flowers is common in naturally pollen‐limited populations. However, floral antagonists may counteract this effect, maintaining smaller‐ and few‐flowered individuals within populations. We quantified pollinator and antagonist visit rates and determined a multiplicative female fitness component from attacked and non‐attacked flowers of the Brazilian hummingbird‐pollinated shrub Collaea cipoensis to determine the selective effects of pollinators and floral antagonists on flower size and number. We predicted that floral antagonists reduce the female fitness component and thus exert negative selective pressures on flower size and number, counteracting the positive effects of pollinators. Pollinators, mainly hummingbirds, comprised 4% of total floral visitation, whereas antagonist ants and bees accounted for 90% of visitation. Nectar‐robbers involved about 99% of floral antagonist visit rates, whereas florivores comprised the remaining 1%. Larger and abundant flowers increased both pollinator and antagonist visit rates and the female fitness component significantly decreased in flowers attacked by nectar‐robbers and florivores in comparison to non‐attacked flowers. We detected that pollinators favored larger‐ and many‐flowered individuals, whereas floral antagonists exerted negative selection on flower size and number. This study confirms that floral antagonists reduce female plant fitness and this pattern directly exerts negative selective pressures on flower size and number, counteracting pollinator‐mediated selection on floral attractiveness traits. 相似文献
944.
A motor neuron strategy to save time and energy in neurodegeneration: adaptive protein stoichiometry 下载免费PDF全文
945.
Sara Bachiller María Angustias Roca-Ceballos Irene García-Domínguez Eva María Pérez-Villegas David Martos-Carmona Miguel Ángel Pérez-Castro Luis Miguel Real José Luis Rosa Lucía Tabares José Luis Venero José Ángel Armengol Ángel Manuel Carrión Rocío Ruiz 《Molecular neurobiology》2018,55(12):8856-8868
A missense mutation in HERC1 provokes loss of cerebellar Purkinje cells, tremor, and unstable gait in tambaleante (tbl) mice. Recently, we have shown that before cerebellar degeneration takes place, the tbl mouse suffers from a reduction in the number of vesicles available for release at the neuromuscular junction (NMJ). The aim of the present work was to study to which extent the alteration in HERC1 may affect other cells in the nervous system and how this may influence the motor dysfunction observed in these mice. The functional analysis showed a consistent delay in the propagation of the action potential in mutant mice in comparison with control littermates. Morphological analyses of glial cells in motor axons revealed signs of compact myelin damage as tomacula and local hypermyelination foci. Moreover, we observed an alteration in non-myelinated terminal Schwann cells at the level of the NMJ. Additionally, we found a significant increment of phosphorylated Akt-2 in the sciatic nerve. Based on these findings, we propose a molecular model that could explain how mutated HERC1 in tbl mice affects the myelination process in the peripheral nervous system. Finally, since the myelin abnormalities found in tbl mice are histological hallmarks of neuropathic periphery diseases, tbl mutant mice could be considered as a new mouse model for this type of diseases. 相似文献
946.
June Bryan de la Peña Irene Joy dela Peña Raly James Custodio Chrislean Jun Botanas Hee Jin Kim Jae Hoon Cheong 《Molecular neurobiology》2018,55(5):3739-3754
Attention-deficit/hyperactivity disorder (ADHD) is a common, behavioral, and heterogeneous neurodevelopmental condition characterized by hyperactivity, impulsivity, and inattention. Symptoms of this disorder are managed by treatment with methylphenidate, amphetamine, and/or atomoxetine. The cause of ADHD is unknown, but substantial evidence indicates that this disorder has a significant genetic component. Transgenic animals have become an essential tool in uncovering the genetic factors underlying ADHD. Although they cannot accurately reflect the human condition, they can provide insights into the disorder that cannot be obtained from human studies due to various limitations. An ideal animal model of ADHD must have face (similarity in symptoms), predictive (similarity in response to treatment or medications), and construct (similarity in etiology or underlying pathophysiological mechanism) validity. As the exact etiology of ADHD remains unclear, the construct validity of animal models of ADHD would always be limited. The proposed transgenic animal models of ADHD have substantially increased and diversified over the years. In this paper, we compiled and explored the validity of proposed transgenic animal models of ADHD. Each of the reviewed transgenic animal models has strengths and limitations. Some fulfill most of the validity criteria of an animal model of ADHD and have been extensively used, while there are others that require further validation. Nevertheless, these transgenic animal models of ADHD have provided and will continue to provide valuable insights into the genetic underpinnings of this complex disorder. 相似文献
947.
Eva De Mol Elzbieta Szulc Claudio Di Sanza Paula Martínez-Cristóbal Carlos W. Bertoncini R. Bryn Fenwick Marta Frigolé-Vivas Marianela Masín Irene Hunter Víctor Buzón Isabelle Brun-Heath Jesús García Gianni De Fabritiis Eva Estébanez-Perpiñá Iain J. McEwan Ángel R. Nebreda Xavier Salvatella 《Structure (London, England : 1993)》2018,26(1):145-152.e3
948.
949.
Eleonora Mauri Robertino Dilena Antonio Boccazzi Dario Ronchi Daniela Piga Fabio Triulzi Delia Gagliardi Roberta Brusa Irene Faravelli Nereo Bresolin Francesca Magri Stefania Corti Giacomo P. Comi 《BMC neurology》2018,18(1):220
Background
Leber’s hereditary optic neuropathy (LHON) is a mitochondrial disease characterized by visual loss consequent to optic nerve atrophy. In some cases, LHON is associated with heterogeneous neurological extraocular manifestations and is referred to as “Leber plus disease”; rarely it is associated with a multiple sclerosis (MS)-like syndrome known as Harding disease, but no pediatric extraocular acute spinal onset is reported.Case presentation
We describe the case of a 5-year-old girl carrying the G3460A mtDNA mutation who was referred to clinical examination for bilateral upper and lower limb weakness with no sign of optic neuropathy. Spinal cord MRI showed hyperintense signal alterations in T2-weighted and restricted diffusion in DWI sequences in the anterior portion of the cervical and dorsal spinal cord resembling a spinal cord vascular injury. No association between this mutation and pediatric spinal cord lesions has previously been reported. Alternative diagnostic hypotheses, including infective, ischemic and inflammatory disorders, were not substantiated by clinical and instrumental investigations.Conclusions
Our case reports a novel pediatric clinical manifestation associated with the m.3460G?>?A mtDNA mutation, broadening the clinical spectrum of this disease. Early identification of new cases and monitoring of carriers beginning in childhood is important to prevent neurological deterioration and preserve long-term function.950.
The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival 下载免费PDF全文
Irene Orlow Yang Shi Peter A. Kanetsky Nancy E. Thomas Li Luo Sergio Corrales‐Guerrero Anne E. Cust Lidia Sacchetto Roberto Zanetti Stefano Rosso Bruce K. Armstrong Terence Dwyer Alison Venn Richard P. Gallagher Stephen B. Gruber Loraine D. Marrett Hoda Anton‐Culver Klaus Busam Colin B. Begg Marianne Berwick the GEM Study Group 《Pigment cell & melanoma research》2018,31(2):287-296
Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3′‐end haplotype were significant (p < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma‐specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined. 相似文献