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排序方式: 共有128条查询结果,搜索用时 15 毫秒
121.
I Guccini D Serio I Cond�� A Rufini B Tomassini A Mangiola G Maira C Anile D Fina F Pallone M P Mongiardi A Levi N Ventura R Testi F Malisan 《Cell death & disease》2011,2(2):e123
Defective expression of frataxin is responsible for the degenerative disease Friedreich''s ataxia. Frataxin is a protein required for cell survival since complete knockout is lethal. Frataxin protects tumor cells against oxidative stress and apoptosis but also acts as a tumor suppressor. The molecular bases of this apparent paradox are missing. We therefore sought to investigate the pathways through which frataxin enhances stress resistance in tumor cells. We found that frataxin expression is upregulated in several tumor cell lines in response to hypoxic stress, a condition often associated with tumor progression. Moreover, frataxin upregulation in response to hypoxia is dependent on hypoxia-inducible factors expression and modulates the activation of the tumor-suppressor p53. Importantly, we show for the first time that frataxin is in fact increased in human tumors in vivo. These results show that frataxin participates to the hypoxia-induced stress response in tumors, thus implying that modulation of its expression could have a critical role in tumor cell survival and/or progression. 相似文献
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Marcello Nicoletti Lamberto Tomassini Juan A. Garbarino Marisa Piovano Maria C. Chamy 《Biochemical Systematics and Ecology》1989,17(7-8):569-572
From Cruckshanksia verticillata, an endemic Chilean species of the family Rubiaceae, a new secoiridoid was isolated in addition to asperuloside and secologanin and identified as 7--methoxysweroside by spectroscopic means. The importance of the isolated iridoids in subfamilial classification of the genus Cruckshanksia is discussed. 相似文献
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Fabrizio Salvi Ilaria Bartolomei Michael H Smolensky Angelo Lorusso Elena Barbarossa Anna Maria Malagoni Paolo Zamboni Roberto Manfredini 《BMC neurology》2010,10(1):105
Background
Temporal, i.e., 24-hour, weekly, and seasonal patterns in the occurrence of acute cardiovascular and cerebrovascular events are well documented; however, little is known about temporal, especially seasonal, variation in multiple sclerosis (MS) and its relapses. This study investigated, by means of a validated chronobiological method, whether severe relapses of MS, ones requiring medical specialty consultation, display seasonal differences, and whether they are linked with seasonal differences in local meteorological variables. 相似文献128.