An investigation of basic assumption in enzyme kinetics using results of the geometric theory of differential equations

Up to the present time, the following property of the product component in the reversible one substrate-one intermediate-one product enzymic mechanism has been taken only as anassumption, viz., during the course of the reaction, the time-rate of change of product concentration is never negative and the product concentration never exceeds its equilibrium value. Applying the methods of the geometric theory of ordinary differential equations it is shown that this result follows as a direct deduction from the differential equations governing the mechanism together with the initial conditions. Further, the nature of the equilibrium point as a stable node is established.     

Coat proteins of strains of two RNA viruses: comparison of their amino acid sequences

Summary The amino acid sequences of four strains of tobacco mosaic virus isolated in different parts of the world are compared. The differences between the strains are discussed with respect to special proteinchemical features (such as beginning of the chain, deletion of amino acids, number of different amino acids, sizes and distribution of regions with invariable amino acids) and with respect to the possibility of deducing the most probable nucleotide sequence for the coat protein cistron of tobacco mosaic virus.The complete amino acid sequences of the two RNA bacteriophage strains fr and f₂ are compared. According to their coat proteins three groups of phages can be formed: 1) MS 2, f₂ M 12 and R 17, 2) fr and 3) Q.