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71.
Aim
The main aim of this study was to assess if the perception of thermal pain thresholds is associated with genetically inferred levels of expression of the 5-HT transporter (5-HTT). Additionally, the perception of the so-called thermal grill illusion (TGI) was assessed. Forty-four healthy individuals (27 females, 17 males) were selected a-priori based on their 5-HTTLPR/rs25531 (‘tri-allelic 5-HTTLPR’) genotype, with inferred high or low 5-HTT expression. Thresholds for heat- and cold-pain were determined along with the sensory and affective dimensions of the TGI.Results
Thresholds to heat- and cold-pain correlated strongly (rho = −0.58, p<0.001). Individuals in the low 5-HTT-expressing group were significantly less sensitive to heat-pain (p = 0.02) and cold-pain (p = 0.03), compared to the high-expressing group. A significant gender-by-genotype interaction also emerged for cold-pain perception (p = 0.02); low 5-HTT-expressing females were less sensitive. The TGI was rated as significantly more unpleasant (affective-motivational dimension) than painful (sensory-discriminatory dimension), (p<0.001). Females in the low 5-HTT expressing group rated the TGI as significantly less unpleasant than high 5-HTT expressing females (p<0.05), with no such differences among men.Conclusion/Significance
We demonstrate an association between inferred low 5-HTT expression and elevated thresholds to thermal pain in healthy non-depressed individuals. Despite the fact that reduced 5-HTT expression is a risk factor for chronic pain we found it to be related to hypoalgesia for threshold thermal pain. Low 5-HTT expression is, however, also a risk factor for depression where thermal insensitivity is often seen. Our results may thus contribute to a better understanding of the molecular underpinnings of such paradoxical hypoalgesia. The results point to a differential regulation of thermoafferent-information along the neuraxis on the basis of 5-HTT expression and gender. The TGI, suggested to rely on the central integration of thermoafferent-information, may prove a valuable tool in probing the affective-motivational dimension of these putative mechanisms. 相似文献72.
Terje Lislevand Bohumír Chutný Ingvar Byrkjedal Václav Pavel Martins Briedis Peter Adamik 《Bird Study》2013,60(4):508-515
Capsule Red-spotted Bluethroats Luscinia s. svecica from two European breeding populations spent the boreal winter on the Indian sub-continent.Aim Tracking the migration of Red-spotted Bluethroats from Europe to the hitherto unknown non-breeding areas and back.Methods Light-level geolocators were deployed on male Bluethroats at breeding sites in the Czech Republic (n?=?10) and in Norway (n?=?30). Recorded light intensity data were used to estimate the locations of non-breeding sites and migration phenology during the annual cycle.Results Bluethroats spent the boreal winter in India (n?=?3) and Pakistan (n?=?1), on average more than 6000?km from their breeding areas. Autumn migration started in August (n?=?1) or early September (n?=?2), and lasted for 26–74 days. Spring migration commenced on 8 and 9 April (n?=?2) and lasted for about a month. During both autumn and spring migration, birds stopped over two or three times for more than 3 days.Conclusion This study for the first time showed where Red-spotted Bluethroats from European breeding populations stay during the boreal winter. This seems to be the first time that a passerine bird has been tracked along the Indo-European flyway. 相似文献
73.
Lack of Adjustment Latitude at Work as a Trigger of Taking Sick Leave—A Swedish Case-Crossover Study
Hanna Hultin Johan Hallqvist Kristina Alexanderson Gun Johansson Christina Lindholm Ingvar Lundberg Jette M?ller 《PloS one》2013,8(4)
Objectives
Research has shown that individuals reporting a low level of adjustment latitude, defined as having few possibilities to temporarily adjust work demands to illness, have a higher risk of sick leave. To what extent lack of adjustment latitude influences the individual when making the decision to take sick leave is unknown. We hypothesize that ill individuals are more likely to take sick leave on days when they experience a lack of adjustment latitude at work than on days with access to adjustment latitude.Methods
A case-crossover design was applied to 546 sick-leave spells, extracted from a cohort of 1 430 employees at six Swedish workplaces, with a 3–12 month follow-up of all new sick-leave spells. Exposure to lack of adjustment latitude on the first sick-leave day was compared with exposure during several types of control periods sampled from the previous two months for the same individual.Results
Only 35% of the respondents reported variations in access to adjustment latitude, and 19% reported a constant lack of adjustment latitude during the two weeks prior to the sick-leave spell. Among those that did report variation, the risk of sick leave was lower on days with lack of adjustment latitude, than on days with access (Odds Ratio 0.36, 95% Confidence Interval 0.25–0.52).Conclusions
This is the first study to show the influence of adjustment latitude on the decision to take sick leave. Among those with variations in exposure, lack of adjustment latitude was a deterrent of sick leave, which is contrary to the à priori hypothesis. These results indicate that adjustment latitude may not only capture long-lasting effects of a flexible working environment, but also temporary possibilities to adjust work to being absent. Further studies are needed to disentangle the causal mechanisms of adjustment latitude on sick-leave. 相似文献74.
Ingvar Byrkjedal Gunnar Langhelle Thomas de Lange Wenneck Rupert Wienerroither 《Polar Biology》2011,34(3):465-467
Adolf’s eelpout, Lycodes adolfi, was found at five bottom trawl stations in 2007–2009, on the slope towards the Sofia Deep north of Spitsbergen, at depths
of 970–1,220 m and water temperatures below 0°C. Previously, the species has been known from cold and deep waters south of
74°N to both sides of Greenland and in the Norwegian Sea. The present material represents the first records from the Arctic
Ocean and may indicate a wider arctic distribution of this species. 相似文献
75.
76.
Resident female Northern Lapwings Vanellus vanellus fight to exclude settlement by secondary females
In systems with bi‐parental care, sexual conflict theory states that a transition from monogamy to polygyny should increase fitness prospects for males and reduce fitness prospects of resident females. Behavioural observations of Northern Lapwings Vanellus vanellus suggested that resident females try to monopolize their breeding resources by attacking females prospecting for secondary status, and males commonly respond by intervening on behalf of the prospecting females. In four territories the resident females successfully defended their monogamous status, in nine territories the resident females made at least one successful eviction before being forced to accept polygyny and in nine territories observed eviction attempts were unsuccessful. These observations indicate that mating status in Northern Lapwings is partly determined by the competitive ability of resident females. 相似文献
77.
Leknes IL 《Zoology (Jena, Germany)》2004,107(3):201-204
This paper describes the localization and structure of melano-macrophage centres (MMCs) in the liver of platyfish (Xiphophorus maculatus), compares these centres with corresponding structures in the spleen and kidney of various teleosts and gives suggestions about their functions. The MMCs were closely apposed to the endothelial layer of liver venules covered with pancreas tissue, i.e. portal venules, and contained numerous cells displaying large amounts of Prussian blue precipitations in tissue treated with acid ferrocyanide. Thus, these centres were rich in ferric compounds, probably haemosiderin, and are suggested to be involved in the normal storage, relocation and recycling of iron compounds from effete or damaged red blood cells of the portal venule system in this species. 相似文献
78.
79.
Berit Sverdrup Henrik K?llberg Camilla Bengtsson Ingvar Lundberg Leonid Padyukov Lars Alfredsson Lars Klareskog the Epidemiological Investigation of Rheumatoid Arthritis study group 《Arthritis research & therapy》2005,7(6):R1296
The aim of the present study was to investigate the association between exposure to mineral oil and the risk of developing
rheumatoid arthritis (RA), and in addition to perform a separate analysis on the major subphenotypes for the disease; namely,
rheumatoid factor (RF)-positive RA, RF-negative RA, anticitrulline-positive RA and anticitrulline-negative RA, respectively.
A population-based case–control study of incident cases of RA was performed among the population aged 18–70 years in a defined
area of Sweden during May 1996–December 2003. A case was defined as an individual from the study base who for the first time
received a diagnosis of RA according to the American College of Rheumatology criteria of 1987. Controls were randomly selected
from the study base with consideration taken for age, gender and residential area. Cases (n = 1,419) and controls (n = 1,674) answered an extensive questionnaire regarding lifestyle factors and occupational exposures, including different
types of mineral oils. Sera from cases and controls were investigated for RF and anticitrulline antibodies. 相似文献
80.
Ebba Brny Ingvar A. Bergdahl Lars-Eric Bratteby Thomas Lundh Gsta Samuelson Staffan Skerfving Agneta Oskarsson 《Journal of trace elements in medicine and biology》2003,17(3):165-170
Mercury and selenium in whole blood and serum of 245 17-year old Swedish adolescents were analysed. The relationships between these elements' concentrations and the consumption of fish as well as the number of dental amalgam fillings were studied. The geometric means (GM) of the mercury concentrations were 1.1 microg/L in blood and 0.43 microg/L in serum. The mean selenium concentration in blood was 110 microg/L and the GM of the serum selenium concentration 110 microg/L. Fish species with dietary restrictions due to elevated mercury Levels (i.e. pike, perch, pikeperch, burbot, eel and halibut) were consumed on average 0.7 times/month and fish species without such restrictions 4.1 times/month. Despite this comparatively low fish consumption, the adolescents' blood mercury concentrations were positively correlated with fish consumption. Of the adolescents, 39% had amalgam fillings (mean 2 +/- 1.5). Serum mercury was influenced by the number of amalgam fillings, by fish consumption, blood and serum levels of selenium and the residential area. Blood and serum selenium concentrations were not influenced by fish consumption, but were positively associated with the serum mercury concentration. 相似文献