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51.
Ola Myklebost Sissel Rogne Ingvar Hjermann Bjørnar Olaisen Hans Prydz 《Human genetics》1990,86(2):209-214
Summary We have analyzed the correlation between restriction site variants (RFLPs; restriction fragment length polymorphisms) of the apolipoprotein AI, AII, B, CI and CII genes and serum lipid levels in a sample of male Norwegians. We find no significant association between any of the RFLPs and lipid levels. 相似文献
52.
Natalie Durbeej Tom Palmstierna Ingvar Rosendahl Anne H. Berman Marianne Kristiansson Clara Hellner Gumpert 《PloS one》2015,10(9)
Substance abuse is related to offending and substance abuse treatment has been associated with reductions in criminal behavior. This cohort study aimed to explore the relationship between participation in substance abuse interventions and general criminal recidivism among offenders with a combination of mental health problems and substance use problems. In total, 150 Swedish offenders with self-reported mental health and substance use problems were followed for approximately three years with regard to participation in substance abuse interventions and criminal recidivism. Participants with at least three planned visits to specialized outpatient substance abuse clinics had a substantially reduced risk of reoffending as compared to those with fewer than three such visits (HR = 0.47, 95% CI 0.29–0.77). For those with at least three planned visits, general criminal recidivism was reduced by 75% during periods of participation in outpatient visits, as compared to periods of non-participation (HR = 0.25, 95% CI 0.11–0.60). For offenders with mental health problems and substance use problems, outpatient substance abuse interventions could be regarded as important from a clinical risk management perspective, and be encouraged. 相似文献
53.
Catherine A. Koss Leah G. Jarlsberg Saskia den Boon Adithya Cattamanchi J. Lucian Davis William Worodria Irene Ayakaka Ingvar Sanyu Laurence Huang International HIV-associated Opportunistic Pneumonias Study 《PloS one》2015,10(5)
BackgroundPneumonia is a major cause of mortality among HIV-infected patients. Pneumonia severity scores are promising tools to assist clinicians in predicting patients’ 30-day mortality, but existing scores were developed in populations infected with neither HIV nor tuberculosis (TB) and include laboratory data that may not be available in resource-limited settings. The objective of this study was to develop a score to predict mortality in HIV-infected adults with pneumonia in TB-endemic, resource-limited settings.MethodsWe conducted a secondary analysis of data from a prospective study enrolling HIV-infected adults with cough ≥2 weeks and <6 months and clinically suspected pneumonia admitted to Mulago Hospital in Kampala, Uganda from September 2008 to March 2011. Patients provided two sputum specimens for mycobacteria, and those with Ziehl-Neelsen sputum smears that were negative for mycobacteria underwent bronchoscopy with inspection for Kaposi sarcoma and testing for mycobacteria and fungi, including Pneumocystis jirovecii. A multivariable best subsets regression model was developed, and one point was assigned to each variable in the model to develop a clinical predictor score for 30-day mortality.ResultsOverall, 835 patients were studied (mean age 34 years, 53.4% female, 30-day mortality 18.2%). A four-point clinical predictor score was identified and included heart rate >120 beats/minute, respiratory rate >30 breaths/minute, oxygen saturation <90%, and CD4 cell count <50 cells/mm3. Patients’ 30-day mortality, stratified by score, was: score 0 or 1, 12.6%, score 2 or 3, 23.4%, score 4, 53.9%. For each 1 point change in clinical predictor score, the odds of 30-day mortality increased by 65% (OR 1.65, 95% CI 1.39-1.96, p <0.001).ConclusionsA simple, four-point scoring system can stratify patients by levels of risk for mortality. Rapid identification of higher risk patients combined with provision of timely and appropriate treatment may improve clinical outcomes. This predictor score should be validated in other resource-limited settings. 相似文献
54.
Jacek Stawiński Roger Strömberg Ingvar Lindh Tor Regberg Thomas Szabó Mats Thelin 《Nucleosides, nucleotides & nucleic acids》2013,32(5-6):799-803
Abstract Ongoing research into the potential of the H-phosphonate method for synthesising oligonucleotides is discussed. Examples include the synthesis of an artificial Haemophilus influenzae antigen and also efforts to extend the method into the automated solid support synthesis of long RNA oligomers. 相似文献
55.
Xin Mei Feng Anna-Ida Johnsson Holmberg Ingvar Sundh Thomas Ricard Petter Melin 《BioControl》2011,56(6):903-913
Several strains from the genus Trichoderma (Ascomycetes, Hypocreales) are commercially used as biocontrol agents, e.g. in formulations containing the two Trichoderma strains IMI206039 (Hypocrea parapilulifera B.S. Lu, Druzhinina & Samuels) and IMI206040 (T. atroviride P. Karst). To quantify the presence of the two isolates after application, we developed primers for SCAR markers (Sequence-Characterised
Amplified Region). In order to quantify both fungal strains simultaneously, we also designed fluorophore-labelled probes distinguishing
the two strains, to be used in combination with the SCAR primers. In incubations of two different soils, artificially inoculated
and maintained under controlled conditions, the quantification through amplification with the SCAR markers in qPCR and through
colony-forming units from plate counting correlated well. Further tests of the markers on samples taken from a golf green
treated with a product containing both strains indicated that the two biocontrol strains did not establish, either on the
golf green or in the surrounding area. 相似文献
56.
Introduction
Fatigue is prevalent in primary Sj?gren's syndrome (pSS), and contributes to the considerably reduced health related quality of life in this disease. The symptom is included in proposed disease activity and outcome measures for pSS. Several studies indicate that there is an inflammatory component of fatigue in pSS and other chronic inflammatory rheumatic diseases. The purpose of this study was to investigate fatigue change in pSS in a longitudinal study, and explore whether any clinical or laboratory variables at baseline, including serum cytokines, were associated with a change in fatigue scores over time. 相似文献57.
Gao K Brandt I Goldstone JV Jönsson ME 《Comparative biochemistry and physiology. Toxicology & pharmacology : CBP》2011,154(1):42-55
Cytochrome P450 1 (CYP1) mRNA induction patterns in three-spined stickleback (Gasterosteus aculeatus) were explored for use in environmental monitoring of aryl hydrocarbon receptor (AHR) agonists. The cDNAs of stickleback CYP1A, CYP1B1, CYP1C1, and CYP1C2 were cloned and their basal and induced expression patterns were determined in the brain, gill, liver and kidney. Also, their induction time courses were compared after waterborne exposure to a transient (indigo) or a persistent (3,3',4,4',5-pentacholorbiphenyl PCB 126) AHR agonist. The cloned stickleback CYP1s exhibited a high amino acid sequence identity compared with their zebrafish orthologs and their constitutive tissue distribution patterns largely agreed with those reported in other species. PCB 126 (100 nM) induced different CYP1 expression patterns in the four tissues, suggesting tissue-specific regulation. Both indigo (1 nM) and PCB 126 (10 nM) induced a strong CYP1 expression in gills. However, while PCB 126 gave rise to a high and persistent induction in gills and liver, induction by indigo was transient in both organs. The number of putative dioxin response elements found in each CYP1 gene promoter roughly reflected the induction levels of the genes. The high responsiveness of CYP1A, CYP1B1, and CYP1C1 observed in several organs suggests that three-spined stickleback is suitable for monitoring of pollution with AHR agonists. 相似文献
58.
Aim
The main aim of this study was to assess if the perception of thermal pain thresholds is associated with genetically inferred levels of expression of the 5-HT transporter (5-HTT). Additionally, the perception of the so-called thermal grill illusion (TGI) was assessed. Forty-four healthy individuals (27 females, 17 males) were selected a-priori based on their 5-HTTLPR/rs25531 (‘tri-allelic 5-HTTLPR’) genotype, with inferred high or low 5-HTT expression. Thresholds for heat- and cold-pain were determined along with the sensory and affective dimensions of the TGI.Results
Thresholds to heat- and cold-pain correlated strongly (rho = −0.58, p<0.001). Individuals in the low 5-HTT-expressing group were significantly less sensitive to heat-pain (p = 0.02) and cold-pain (p = 0.03), compared to the high-expressing group. A significant gender-by-genotype interaction also emerged for cold-pain perception (p = 0.02); low 5-HTT-expressing females were less sensitive. The TGI was rated as significantly more unpleasant (affective-motivational dimension) than painful (sensory-discriminatory dimension), (p<0.001). Females in the low 5-HTT expressing group rated the TGI as significantly less unpleasant than high 5-HTT expressing females (p<0.05), with no such differences among men.Conclusion/Significance
We demonstrate an association between inferred low 5-HTT expression and elevated thresholds to thermal pain in healthy non-depressed individuals. Despite the fact that reduced 5-HTT expression is a risk factor for chronic pain we found it to be related to hypoalgesia for threshold thermal pain. Low 5-HTT expression is, however, also a risk factor for depression where thermal insensitivity is often seen. Our results may thus contribute to a better understanding of the molecular underpinnings of such paradoxical hypoalgesia. The results point to a differential regulation of thermoafferent-information along the neuraxis on the basis of 5-HTT expression and gender. The TGI, suggested to rely on the central integration of thermoafferent-information, may prove a valuable tool in probing the affective-motivational dimension of these putative mechanisms. 相似文献59.
Terje Lislevand Bohumír Chutný Ingvar Byrkjedal Václav Pavel Martins Briedis Peter Adamik 《Bird Study》2013,60(4):508-515
Capsule Red-spotted Bluethroats Luscinia s. svecica from two European breeding populations spent the boreal winter on the Indian sub-continent.Aim Tracking the migration of Red-spotted Bluethroats from Europe to the hitherto unknown non-breeding areas and back.Methods Light-level geolocators were deployed on male Bluethroats at breeding sites in the Czech Republic (n?=?10) and in Norway (n?=?30). Recorded light intensity data were used to estimate the locations of non-breeding sites and migration phenology during the annual cycle.Results Bluethroats spent the boreal winter in India (n?=?3) and Pakistan (n?=?1), on average more than 6000?km from their breeding areas. Autumn migration started in August (n?=?1) or early September (n?=?2), and lasted for 26–74 days. Spring migration commenced on 8 and 9 April (n?=?2) and lasted for about a month. During both autumn and spring migration, birds stopped over two or three times for more than 3 days.Conclusion This study for the first time showed where Red-spotted Bluethroats from European breeding populations stay during the boreal winter. This seems to be the first time that a passerine bird has been tracked along the Indo-European flyway. 相似文献
60.
Lack of Adjustment Latitude at Work as a Trigger of Taking Sick Leave—A Swedish Case-Crossover Study
Hanna Hultin Johan Hallqvist Kristina Alexanderson Gun Johansson Christina Lindholm Ingvar Lundberg Jette M?ller 《PloS one》2013,8(4)