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71.
Specimens of Raja clavata were monthly collected at the coast of Havaalan? (Trabzon/Turkey) from January 2009 to December 2009 at depths between 20 and 40?m. A total of 230 individuals of thornback ray (131 females and 99 males) were collected by bottom trawls during research cruises. Using logistic regression, it was determined that TL at 50% maturity of males was 718?mm TL and of females 746?mm TL. The ovarian fecundity ranged from 27 to 60 yellow follicles in both ovaries. Females carrying egg cases were found in July and October. Variations in the gonadosomatic and hepatosomatic indices indicated a continuous reproductive cycle during the year. 相似文献
72.
Jelani Ince 《Ethnic and racial studies》2018,41(8):1428-1434
This paper focuses on the contributions of Chris Lebron's book The Making of Black Lives Matter: The History of an Idea. Specifically, I examine his discussion of James Baldwin, Martin Luther King, Jr., and Audre Lorde and their opinions about love for their community, black self-actualization, and black liberation. I consider whether or not rage should play a role in our opinions about the #BlackLivesMatter movement and discuss whether or not it hurts the pursuit of freedom. I agree with the importance to look to the past in order to inform our political behaviour moving forward. Nonetheless, if we are to align with the #BlackLivesMatter movement, we must be willing to challenge what is often considered to be “proper” dissent. The review concludes with hypotheses about what black Americans should do as we work to reimagine a society where oppression is not integral to the maintenance of the American project. 相似文献
73.
Nimodipine confers clinical improvement in two models of experimental autoimmune encephalomyelitis 下载免费PDF全文
Jens Ingwersen Lorenzo De Santi Britta Wingerath Jonas Graf Barbara Koop Reiner Schneider Christina Hecker Friederike Schröter Mary Bayer Anna Dorothee Engelke Michael Dietrich Philipp Albrecht Hans‐Peter Hartung Pasquale Annunziata Orhan Aktas Tim Prozorovski 《Journal of neurochemistry》2018,146(1):86-98
74.
In the current study, fifteen halophilic and halotolerant bacteria were isolated from salt-affected soil of ?anl?urfa, Turkey. The isolates were characterized by conventional and molecular techniques (16S rDNA sequence analyses) as belonging to seven different genus including Bacillus (5 isolates), Halobacillus (1 isolate), Oceanobacillus (2 isolates), Halomonas (3 isolate), Nesterenkonia (1 isolate), Chromohalobacter (2 isolates) and Jeotgalibacillus (2 isolates). According to the results obtained, the investigated bacterial strains have high salt tolerance and significant enzyme activities which can improve soil nutrient cycling and fertility. Furthermore, these bacterial strains have been investigated for their ability to dissolve common salts available in salt-affected soils. Salt dissolving experiments showed that two Chromohalobacter isolates were able to dissolve CaCO3 and one of the Halomonas isolate was able to dissolve both CaCO3 and MgCO3. As these bacterial isolates can dissolve CaCO3 and MgCO3, the availability of Ca2+ and Mg2+ ions may increase which can enhance the removal of the excess Na+ in soil profile. 相似文献
75.
Ince TA Ward JM Valli VE Sgroi D Nikitin AY Loda M Griffey SM Crum CP Crawford JM Bronson RT Cardiff RD 《Nature biotechnology》2008,26(9):978-9; discussion 979
76.
Balci-Peynircioglu B Waite AL Schaner P Taskiran ZE Richards N Orhan D Gucer S Ozen S Gumucio D Yilmaz E 《Experimental biology and medicine (Maywood, N.J.)》2008,233(11):1324-1333
Familial Mediterranean fever (FMF) is characterized by recurrent attacks of fever and serositis; in some cases, ensuing amyloidosis results in kidney damage. Treatment with colchicine reduces the frequency and severity of FMF attacks and prevents amyloidosis, although the mechanisms behind these effects are unknown. Pyrin, the protein product of the MEFV gene, interacts with ASC, a key molecule in apoptotic and inflammatory processes. ASC forms intracellular speck-like aggregates that presage cell death. Here we show that cell death after ASC speck formation is much slower in nonmyeloid cells than in myeloid cells. Additionally, we demonstrate that colchicine prevents speck formation and show that specks can survive in the extracellular space after cell death. Because we also found that ASC is expressed in renal glomeruli of patients with FMF but not in those of control patients, we posit that high local ASC expression may result in speck formation and that specks from dying cells may persist in the extracellular space where they have the potential (perhaps in association with pyrin) to nucleate amyloid. The fact that speck formation requires an intact microtubule network as shown here could potentially account for the ability of prophylactic colchicine to prevent or reverse amyloidosis in patients with FMF. 相似文献
77.
78.
Stefan Stich Marion Haag Thomas Häupl Orhan Sezer Michael Notter Christian Kaps Michael Sittinger Jochen Ringe 《Cell and tissue research》2009,336(2):225-236
In situ tissue engineering is a promising approach in regenerative medicine, with the possibility that adult stem or progenitor
cells will be guided chemotactically to a tissue defect and subsequently differentiate into the surrounding tissue type. Mesenchymal
stem cells (MSC) represent attractive candidate cells. Chemokines such as CXCL12 (SDF-1α) chemoattract MSC, but little is
known about the molecular processes involved in the chemotaxis and migration of MSC. In this study, MSC recruitment by CXCL12
was investigated by genome-wide microarray analysis. The dose-dependent migration potential of bone-marrow-derived MSC toward
CXCL12 was measured in an in vitro assay, with a maximum being recorded at a concentration of 1,000 nM CXCL12. Microarray
analysis of MSC stimulated with CXCL12 and non-stimulated controls showed 30 differentially expressed genes (24 induced and
six repressed). Pathway analysis revealed 11 differentially expressed genes involved in cellular movement and cytokine-cytokine
receptor interaction, including those for migratory inducers such as the chemokines CXCL8 and CCL26, the leukocyte inhibitory
factor, secretogranin II, and prostaglandin endoperoxide synthase 2. These results were confirmed by real-time polymerase
chain reaction for selected genes. The obtained data provide further insights into the molecular mechanisms involved in chemotactic
processes in cell migration and designate CXCL12 as a promising candidate for in situ recruitment in regenerative therapies.
Stefan Stich and Marion Haag contributed equally to this work.
This study was supported by the Investitionsbank Berlin and the European Regional Development Fund (grant: 10128098), Deutsche
Forschungsgemeinschaft (grant: DFG SI 569/7–1), and the Bundesministerium für Bildung und Forschung (Bioinside: 13N9817). 相似文献
79.
Ayhan Dogukan Nurhan Sahin Mehmet Tuzcu Vijaya Juturu Cemal Orhan Muhittin Onderci James Komorowski Kazim Sahin 《Biological trace element research》2009,131(2):124-132
The present study was conducted to investigate the effects of chromium histidinate (CrHis) against experimentally induced
type II diabetes and on chromium (Cr), zinc (Zn), selenium (Se), manganese (Mn), iron (Fe), and copper (Cu) in serum, liver,
and kidney of diabetic rats. The male Wistar rats (n = 60, 8 weeks old) were divided into four groups. Group I received a standard diet (12% of calories as fat); group II were
fed standard diet and received CrHis (110 mcg CrHis/kg body weight per day); group III received a high-fat diet (HFD; 40% of calories as fat) for 2 weeks and then
were injected with streptozotocin (STZ) on day 14 (STZ, 40 mg/kg i.p.; HFD/STZ); group IV were treated as group III (HFD/STZ)
but supplemented with 110 mcg CrHis/kg body weight per day. The mineral concentrations in the serum and tissue were determined
by atomic absorption spectrometry. Compared to the HFD/STZ group, CrHis significantly increased body weight and reduced blood
glucose in diabetic rats (p < 0.001). Concentrations of Cr, Zn, Se, and Mn in serum, liver, and kidney of the diabetic rats were significantly lower
than in the control rats (p < 0.0001). In contrast, higher Fe and Cu levels were found in serum and tissues from diabetic versus the non-diabetic rats
(p < 0.001). Chromium histidinate supplementation increased serum, liver, and kidney concentrations of Cr and Zn both in diabetic
and non-diabetic rats (p < 0.001). Chromium supplementation increased Mn and Se levels in diabetic rats (p < 0.001); however, it decreased Cu levels in STZ-treated group (p < 0.001). Chromium histidinate supplementation did not affect Fe levels in both groups (p > 0.05). The results of the present study conclude that supplementing Cr to the diet of diabetic rats influences serum and
tissue Cr, Zn, Se, Mn, and Cu concentrations. 相似文献
80.