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921.
Ina Schulte E-juan Zhang Zhong-ji Meng Rong-juan Pei Mengji Lu Michael Roggendorf 《中国病毒学》2008,23(2):107-115
The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infection. Recently, a new assay for cytotoxic T-cells based on detection of CD107 was established for the woodchuck model. In addition, new immunotherapeutic approaches based on combination of potent antiviral treatment and DNA-protein vaccines were proven to be useful for treatment of chronic hepatitis B. 相似文献
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Groups of Hodotermes mossambicus reproductives exhibit social behaviour. Maintenance of this behaviour by an individual depends on frequent contact of its body by the antennae of other termites. The antennae of the recipient do not play a rôle. Pairs on the other hand exhibit antisocial behaviour. Development of pair behaviour occurs when antenna to body contact is reduced or absent. Furthermore, at least the proximal parts of the antennae are required for full development of pair behaviour. Pheromones are not implicated in the change from group to pair behaviour. 相似文献
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Feng-Liu Wang Ya-Lan Tan Lukas Wallrad Xin-Qiao Du Anna Eickelkamp Zhi-Fang Wang Ge-Feng He Felix Rehms Zhen Li Jian-Pu Han Ina Schmitz-Thom Wei-Hua Wu Jörg Kudla Yi Wang 《Developmental cell》2021,56(6):781-794.e6
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Yasuo Ina Masashi Mizokami Kenichi Ohba Takashi Gojobori 《Journal of molecular evolution》1994,38(1):50-56
Molecular evolutionary analyses were carried out to elucidate the phylogenetic relationships, the evolutionary rate, and the divergence times of hepatitis C viruses. Using the nucleotide sequences of the viruses isolated from various locations in the world, we constructed phylogenetic trees. The trees showed that strains isolated from a single location were not necessarily clustered as a group. This suggests that the viruses may be transferred with blood on a worldwide scale. We estimated the evolutionary rates at synonymous and nonsynonymous sites for all genes in the viral genome. We then found that the rate (1.35 × 10–3 per site per year) at synonymous sites for the C gene was much smaller than those for the other genes (e.g., 6.29 × 10–3 per site per year for the E gene). This indicates that a special type of functional constraint on synonymous substitutions may exist in the C gene. Because we found an open reading frame (ORF) with the C gene region, the possibility exists that synonymous substitutions for the C gene are constrained by the overlapping ORF whose reading frame is different from that of the C gene. Applying the evolutionary rates to the trees, we also suggest that major groups of hepatitis C viruses diverged from their common ancestor several hundred years ago.
Correspondence to: T. Gojobori 相似文献
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