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941.
Groups of Hodotermes mossambicus reproductives exhibit social behaviour. Maintenance of this behaviour by an individual depends on frequent contact of its body by the antennae of other termites. The antennae of the recipient do not play a rôle. Pairs on the other hand exhibit antisocial behaviour. Development of pair behaviour occurs when antenna to body contact is reduced or absent. Furthermore, at least the proximal parts of the antennae are required for full development of pair behaviour. Pheromones are not implicated in the change from group to pair behaviour. 相似文献
942.
943.
Feng-Liu Wang Ya-Lan Tan Lukas Wallrad Xin-Qiao Du Anna Eickelkamp Zhi-Fang Wang Ge-Feng He Felix Rehms Zhen Li Jian-Pu Han Ina Schmitz-Thom Wei-Hua Wu Jörg Kudla Yi Wang 《Developmental cell》2021,56(6):781-794.e6
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944.
Hanjue Xia Johannes Horn Monika J. Piotrowska Konrad Sakowski Andr Karch Hannan Tahir Mirjam Kretzschmar Rafael Mikolajczyk 《PLoS computational biology》2021,17(5)
In the year 2020, there were 105 different statutory insurance companies in Germany with heterogeneous regional coverage. Obtaining data from all insurance companies is challenging, so that it is likely that projects will have to rely on data not covering the whole population. Consequently, the study of epidemic spread in hospital referral networks using data-driven models may be biased. We studied this bias using data from three German regional insurance companies covering four federal states: AOK (historically “general local health insurance company”, but currently only the abbreviation is used) Lower Saxony (in Federal State of Lower Saxony), AOK Bavaria (in Bavaria), and AOK PLUS (in Thuringia and Saxony). To understand how incomplete data influence network characteristics and related epidemic simulations, we created sampled datasets by randomly dropping a proportion of patients from the full datasets and replacing them with random copies of the remaining patients to obtain scale-up datasets to the original size. For the sampled and scale-up datasets, we calculated several commonly used network measures, and compared them to those derived from the original data. We found that the network measures (degree, strength and closeness) were rather sensitive to incompleteness. Infection prevalence as an outcome from the applied susceptible-infectious-susceptible (SIS) model was fairly robust against incompleteness. At incompleteness levels as high as 90% of the original datasets the prevalence estimation bias was below 5% in scale-up datasets. Consequently, a coverage as low as 10% of the local population of the federal state population was sufficient to maintain the relative bias in prevalence below 10% for a wide range of transmission parameters as encountered in clinical settings. Our findings are reassuring that despite incomplete coverage of the population, German health insurance data can be used to study effects of patient traffic between institutions on the spread of pathogens within healthcare networks. 相似文献
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946.
947.
Yasuo Ina Masashi Mizokami Kenichi Ohba Takashi Gojobori 《Journal of molecular evolution》1994,38(1):50-56
Molecular evolutionary analyses were carried out to elucidate the phylogenetic relationships, the evolutionary rate, and the divergence times of hepatitis C viruses. Using the nucleotide sequences of the viruses isolated from various locations in the world, we constructed phylogenetic trees. The trees showed that strains isolated from a single location were not necessarily clustered as a group. This suggests that the viruses may be transferred with blood on a worldwide scale. We estimated the evolutionary rates at synonymous and nonsynonymous sites for all genes in the viral genome. We then found that the rate (1.35 × 10–3 per site per year) at synonymous sites for the C gene was much smaller than those for the other genes (e.g., 6.29 × 10–3 per site per year for the E gene). This indicates that a special type of functional constraint on synonymous substitutions may exist in the C gene. Because we found an open reading frame (ORF) with the C gene region, the possibility exists that synonymous substitutions for the C gene are constrained by the overlapping ORF whose reading frame is different from that of the C gene. Applying the evolutionary rates to the trees, we also suggest that major groups of hepatitis C viruses diverged from their common ancestor several hundred years ago.
Correspondence to: T. Gojobori 相似文献
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949.
Ronan Sulpice Agata Sienkiewicz-Porzucek Sonia Osorio Ina Krahnert Mark Stitt Alisdair R. Fernie Adriano Nunes-Nesi 《Amino acids》2010,39(4):1055-1066
Transgenic tomato (Solanum lycopersicum) plants were generated targeting the cytosolic NADP-dependent isocitrate dehydrogenase gene (SlICDH1) via the RNA interference approach. The resultant transformants displayed a relatively mild reduction in the expression
and activity of the target enzyme in the leaves. However, biochemical analyses revealed that the transgenic lines displayed
a considerable shift in metabolism, being characterized by decreases in the levels of the TCA cycle intermediates, total amino
acids, photosynthetic pigments, starch and NAD(P)H. The plants showed little change in photosynthesis with the exception of
a minor decrease in maximum photosynthetic efficiency (F
v/F
m), and a small decrease in growth compared to the wild type. These results reveal that even small changes in cytosolic NADP-dependent
isocitrate dehydrogenase activity lead to noticeable alterations in the activities of enzymes involved in primary nitrate
assimilation and in the synthesis of 2-oxoglutarate derived amino acids. These data are discussed within the context of current
models for the role of the various isoforms of isocitrate dehydrogenase within plant amino acid metabolism. 相似文献
950.