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331.
Molecular Biology Reports - Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related death mainly due to its high metastatic rate. Impairment of redox homeostasis mechanisms...  相似文献   
332.
The synthesis, characterization, crystal structure, thermal stability, optical spectroscopic, electronic structure, and second-order nonlinear optical (NLO) properties of a novel class of materials, based on planar [N4]Ni(II) complexes, are reported. The single-crystal X-ray structure of the dichloro derivative indicates a planar structure of the molecule. The Ni(II) ion is tetracoordinated in a square planar environment, with the four nitrogen atoms as donors. The unsubstituted derivative exhibits efficiency 1.2 times that of urea in second-harmonic generation at 1.9 μm. INDO/SCI-SOS quantum-chemical calculations predict a sizeable molecular response and a significant octupolar contribution to optical nonlinearity.  相似文献   
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334.
K+ -dependent p-nitrophenylphosphatase (pNPPase) and Ca++ -stimulated adenosine triphosphatase (ATPase) activities were studied in human parotid and submandibular glands using cytochemical methods at the ultrastructural level. In both glands, only the striated-duct epithelium showed K+ -pNPPase reaction product, thereby indicating the localization of Na+, K+ -ATPase. The precipitate was concentrated on the deep invaginations of the basolateral plasma membranes, in close association with their cytoplasmic surface. Ca++ -ATPase activity was also found on the basolateral plasma membranes, but two striking differences from the K+ -pNPPase distribution were observed: firstly, Ca++ -ATPase appeared in both acinar and ductal cells, and secondly, it was localized on the outer side of the plasma membranes.  相似文献   
335.
Limb bud cells were isolated from HH stage 22–23 chick embryos and were grown as a ‘spot culture’ in in vitro conditions which support their differentiation into chondrocytes and myotubes. By day 4 of culture, numerous chondrocyte nodules developed and were scattered mainly in the very centre of the cell spot. In contrast, multinucleated myotubes formed at both the centre and the periphery of the cell spot. Treatment with vitamin A starting on day 1, inhibited chondrogenesis in these cultures, and by day 4–6 chondrocyte nodules could not be detected histologically. In contrast, no dose of vitamin A tested was effective in suppressing the development of multi-nucleated myotubes. These data show that vitamin A selectively inhibits chondrogenesis but not myogenesis in limb bud cell cultures.  相似文献   
336.
Species distributions are structured by regional and local determinants, which operate at multiple spatial and temporal scales. The purpose of our work was to distinguish the relative roles of local variables, climate, geographical location and post glaciation condition (i.e., delineation between supra- and subaquatic lakes during the post-glacial Ancylus Lake) in explaining variation in macrophyte community composition of all taxa, helophytes and hydrophytes. In addition, we investigated how these four explanatory variable groups affected macrophyte strategy groups based on Grime’s classification. Using partial linear regression and variation partitioning, we found that macrophyte communities are primarily filtered by local determinants together with regional characteristics at the studied spatial scale. We further evidenced that post glaciation condition indirectly influenced on local water quality variables, which in turn directly contributed to the macrophyte communities. We thus suggest that regional determinants interact with local-scale abiotic factors in explaining macrophyte community patterns and examining only regional or local factors is not sufficient for understanding how aquatic macrophyte communities are structured locally and regionally.  相似文献   
337.
The composition of neutral lipids and phospholipids was determined in normal (Cb7) and dystrophic (DyA4) cell lines, derived from cloned satellite cells from control and dystrophic C57BL/6J/dydy mice. The results obtained showed that dystrophic cells contain a higher relative distribution of phospholipids than their normal counterparts. Moreover, the distribution of individual phospholipids differs between normal and dystrophic cells, with increased percentage of acidic phospholipids and reduced proportion of phosphatidylcholine in dystrophic cells. Cholesterol was increased but free fatty acids decreased in dystrophic cells. The possible pathogenetic significance and functional consequences of these abnormalities are discussed.  相似文献   
338.
Satellite cells were isolated from leg skeletal muscles of adult mice and grown in culture. During the first few days in culture, satellite cells actively proliferated and starting on day 4 began to fuse into multinucleated myotubes. At various time points during the culture period, the biosynthesis of total cellular proteins and glycoproteins was analysed by pulse-labelling with radioactive leucine or sugars followed by electrophoretic analysis on two-dimensional gels. Our findings are: (1) Replicating mononucleated satellite cells on day 1 of culture did not synthesize detectable amounts of α and β tropomyosins, α-actin, and myosin light chains 1 and 2; (2) the synthesis of these polypeptides was readily detectable in multinucleated myotubes that formed by day 5–6 of culture; (3) other qualitative and quantitative differences in as yet unidentified proteins were observed in replicating cells as compared with multinucleated myotubes as well as to muscle fibroblasts; and (4) at least two distinct glucosamine-containing acidic glycoproteins of about 70 000 D and pI 5 were synthesized by myotubes, but not by replicating satellite cells.These data demonstrate that the biosynthetic programs for proteins and glycoproteins of cultured replicating satellite cells can be distinguished from those of multinucleated myotubes and from those of muscle fibroblasts. These data are interpreted to indicate that during muscle histogenesis in vivo, satellite cells become arrested prior to the expression of terminally differentiated traits.  相似文献   
339.
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