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51.
52.
V A Kashkin N A Patkina A Ia Bagrov Ia Iu Bagrov E E Zvartau 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2001,87(5):665-669
Intraperitoneal administration of marinobufagenin resulted in a reliable and dose-dependent suppression of ethanol self-administration in drug- and experimentally naive DBA/2 mice. The findings suggest that Na/K-ATPase contributes to both mediation of the ethanol reinforcing properties and the mood regulation. 相似文献
53.
V Ia Bykhovski? N I Za?tseva A F Mironov N S Osin E V Pecherskikh V D Rumiantseva G M Sukhin 《Prikladnaia biokhimiia i mikrobiologiia》2001,37(6):660-668
Methods of synthesis of coproporphyrin and uroporphyrin by using bacteria of the genus Arthrobacter are proposed. Metal complexes of coproporphyrin and uroporphyrin with Pt, Pd, and Zn were synthesized. Their structures were identified by spectrophotometry, IR spectrometry, 1H-NMR, mass spectrometry, and HPLC. Data showing the possibility to use coproporphyrin III-metal complexes as luminophores for fluorescence detection of tumors. The current and prospective uses of metal complexes of water-soluble natural porphyrins in advanced immunofluorescence assays are discussed. 相似文献
54.
A A Lipanov I Ia Skuratovski? V I Poltev A G Golovinskaia V P Chuprina 《Molekuliarnaia biologiia》1987,21(6):1645-1654
The results of X-ray diffraction studies of poly(dA).poly(dT) have been compared with the results of energy optimization and with the NMR data in solution. Slight refinement of the X-ray and energetically optimal models leads to a very good quantitative agreement with the NMR data, that suggests similarity of the poly(dA).poly(dT) structure in a condensed state and in solution. One of the features distinguishing these models from the classic B form is a narrowed minor groove of the double helix. The anomalous properties of DNA with this sequence can be related specific organization of the water molecules near the polynucleotide. 相似文献
55.
Complex studies of parasitic cenoses of four species of gerbils were carried out in Turkmenia. Over 60 forms of parasites were found out as follows: three species of blood parasites, 12 species of Coccidia, 8 species of cestodes, 12 species of nematodes, one species of Acanthocephalus, three species of chigger mites, 15 species of gamasid mites, 6 species of ixodid ticks, fleas and lice. The list of species of parasites with regard to their hosts is provided. 相似文献
56.
A study was made of the structural changes in different organoids of enterocytes of the rat small intestine at "rest" and during lipid absorption using ultrathin sections, impregnation with Ur-Pb-Cu, and continuous impregnation with OsO4. With the latter technique a specific canalicular system was found in the enterocytes, which we failed to observe on ultrathin sections. During lipid absorption the canalicular system underwent fragmentation. The vesicules on the trans-surface of the Golgi apparatus were enlarged, and the number of flattened cisterns was significantly lower. The changes in cellular organoids and their interrelations observed in the present study support the earlier hypothesis of the resynthesis of triglycerides within the enterocytes, the formation of chylomicrons and their transfer into the intercellular space. 相似文献
57.
A Ia Kaplan 《Zhurnal evoliutsionno? biokhimii i fiziologii》1987,23(4):492-496
In acute experiments on immobilized carps, under dark adaptation conditions, studies have been made on the electrical activity of the telencephalon and midbrain tectum. It was found that in the latter photostimulation evokes local rhythmic activity which includes fast (30-50 Hz) phasic (200-300 ms) and slow (8-14 Hz) tonic (up to 3-4 s) components. High rhythm of this activity may be observed only in "healthy" preparations, coinciding with on-rhythm in the midbrain tectum. Low rhythm does not depend on the presence of rhythmic activity in the tectum. Various aspects of the development of the thalamo-telencephalic system in vertebrates are discussed. 相似文献
58.
Changes in the total number of hepatocytes, their distribution by the ploidy classes, as well as changes in the protein content of the cells were studied in 0.5-6 month old mice. The data obtained made it possible to estimate quantitatively the contribution of different growth components: increase in cell number, hypertrophy and polyploidization of cells, to the total increase of the liver mass. From 2 weeks to 1 month, the liver mass is increased via polyploidization (by 70%) and hypertrophy (by 30%). From 1 to 2 months, the liver mass increases due to hyperplasia (by 65%) and polyploidization (35%). After 2 months, the liver growth is practically terminated. The calculated equivalent mass of the liver, i. e. derivative of all three growth components, coincides fairly well with the factual changes in the liver mass. 相似文献
59.
V V Tsibinogin A A Kraevski? R Sh Bibilashvili E Ia Gren L L Kiselev 《Molekuliarnaia biologiia》1989,23(4):983-987
Several nucleoside 5'-triphosphate analogs were investigated as inhibitors of human hepatitis B virus replication. Different analogs inhibited DNA synthesis differently, 3'-azido-2',3'-dideoxythymidine 5'triphosphate being the most active compound. This inhibitor blocked DNA synthesis by 50% at inhibitor: substrate molar ratio 1:8, and by 80% - at 1:1. The hypothesis is formulated that 3'-azido-2',3'-dideoxythymidine 5'-triphosphate inhibits RNA directed viral DNA replication due to incorporation of this compound into 3'-termini of newly synthesized DNA chains. The phenomenon observed opens new possibilities for chemotherapy of acute and chronic human hepatitis B. 相似文献
60.