A cultured concentrated inactivated vaccine against tick-borne encephalitis studied during the immunization of children and adolescents

The word deals with the results obtained in the study of the reactogenicity and immunological activity of concentrated and inactivated tissue-culture tick-borne encephalitis vaccine, manufactured by the Chumakov Institute of Poliomyelitis and Viral Encephalitides, in the immunization of children and adolescents. The vaccine proved to be moderately reactogenic and exhibited pronounced immunological activity. In 91.5% of the immunized children the fourfold increase of the antibody level was observed. On the basis of the data obtained in this study the tick-borne encephalitis vaccine was recommended for use in medical practice for the prophylaxis of tick-borne encephalitis among children and adolescents.     

Adaptive changes in fatty acid compositions of whitefish Coregonus lavaretus L. tissue lipids induced by anthropogenic factors]

Adaptive processes in the body of whitefish (Coregonus lavaretus L.) caused by anthropogenic effects on aquatic systems were studied. It was demonstrated that the content of fatty acid acyls correlated with the water pollution level. The role of a decrease in the content of arachidonic acid in fish reproduction under adverse conditions is discussed. It is underlined that the quantitative alterations in the gonad and liver fatty acid patterns are unidirectional. A compensatory character of the changes discovered is hypothesized.     

Effects of combined influence of ionizing radiation and light on the retina

The continuous irradiation of rats with a light (3500 1x) for 48 hours led to destruction of 7.5 +/- 0.43% of neurosensoric cells (the control value was 0.2 +/- (0.02%). Longer photodamage caused progressing decrease in a population of the cells, narrowing followed by disappearance of corresponding layers of retina by the 30th day of the experiment. Preliminary exposure to X-rays with a dose of 5 Gy modified light damages of retina. The combination of two factors caused death of more than 30% of neurosensoric cells and redused the number of rows of nucleis of the external nuclear layer twice for the first 48 hours of illumination. After a longer influence of light a preliminary ionizing irradiation increased the number of destructively changed neurosensoric cells, reaching minimun of 41.7% by 30th day of the experiment. At the same time after a long combined irradiation less changes in row number quantity, numerical density of nucleus of the external nuclear layer and a population of neurosesoric cells in general was observed than after only one light exposure. Changes of choriocapillaries (thrombosis, obliteration, narrowing of a gap) which were more expressed at a combination of factors, led to infringement of blood circulation and played the important role in mechanisms of retina degeneration. Radial glia and neurons of internal layers of retina showed relative resistance to the investigated influences.     

Radioprotective efficacy of chitosan, dissolved in aqueous extract of Abies Sibirica

In experiments on rats it has been shown, that radioprotective efficacy of water-soluble low-molecular chitosan (MM 23 kDa) used in a dose 5 mg/kg (per os 5 ml/kg, daily ten-day treatment after whole-body irradiation with LD90/30) is higher, when it is dissolved in Abisib (aqueous extract of Abies Sibirica fir-needles) in comparison with chitosan dissolved in distilled water. Survival rate and average life significantly increase. Radioprotective efficacy of water-soluble low-molecular chitosan in a dose 5 mg/kg dissolved in distilled water or in Abisib (Chitabis) has been estimated. In comparison with control rats exposed to LD90/30, Chitabis administration (per os 5 ml/kg, daily ten-day treatment) leads to increase of average life from 15.44 +/- 2.31 to 28.37 +/- 3.09 days and of survival rate from 9.75 +/- 7.75% to 34.0 +/- 3.6%.     

Polysystemic assessment of the state of sanogenesis in workers employed in nuclear fuel plants. The analysis of functional state of cardiovascular, respiratory, and psychomotor systems

The state of the cardiovascular, respiratory, and psychomotor systems of workers employed in nuclear fuel plant was evaluated using a computer-assisted laboratory complex. It was found that neuroendocrine regulation of the peripheral circulation and muscular activity responsible for fine motions are most vulnerable to industrial hazardous factors.