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61.
Seipke RF Crossman L Drou N Heavens D Bibb MJ Caccamo M Hutchings MI 《Journal of bacteriology》2011,193(16):4270-4271
Streptomyces spp. are common symbionts of the leaf-cutting ant species Acromyrmex octospinosus, which feeds on basidiomycete fungus leaf matter and harvests the lipid- and carbohydrate-rich gongylidia as a food source. A. octospinosus and other ant genera use antifungal compounds produced by Streptomyces spp. and other actinomycetes in order to help defend their fungal gardens from parasitic fungi. Herein, we report the draft genome sequence of Streptomyces strain S4, an antifungal-producing symbiont of A. octospinosus. 相似文献
62.
The nature of fisheries- and farming-induced evolution 总被引:3,自引:1,他引:2
Humans have a penchant for unintentionally selecting against that which they desire most. In fishes, unprecedented reductions in abundance have been associated with unprecedented changes in harvesting and aquaculture technologies. Fishing, the predominant cause of fish-population collapses, is increasingly believed to generate evolutionary changes to characters of import to individual fitness, population persistence and levels of sustainable yield. Human-induced genetic change to wild populations can also result from interactions with their domesticated counterparts. Our examination of fisheries- and farming-induced evolution includes factors that may influence the magnitude, rate and reversibility of genetic responses, the potential for shifts in reaction norms and reduced plasticity, loss of genetic variability, outbreeding depression and their demographic consequences to wild fishes. We also suggest management initiatives to mitigate the effects of fisheries- and farming-induced evolution. Ultimately, the question of whether fishing or fish farming can cause evolutionary change is moot. The key issue is whether such change is likely to have negative conservation- or socio-economic consequences. Although the study of human-induced evolution on fishes should continue to include estimates of the magnitude and rate of selection, there is a critical need for research that addresses short- and long-term demographic consequences to population persistence, plasticity, recovery and productivity. 相似文献
63.
G protein-coupled receptors (GPCRs) are one of the most important classes of targets for small molecule drug discovery, but many current GPCRs of interest are proving intractable to small molecule discovery and may be better approached with bio-therapeutics. GPCRs are implicated in a wide variety of diseases where antibody therapeutics are currently used. These include inflammatory diseases such as rheumatoid arthritis and Crohn disease, as well as metabolic disease and cancer. Raising antibodies to GPCRs has been difficult due to problems in obtaining suitable antigen because GPCRs are often expressed at low levels in cells and are very unstable when purified. A number of new developments in overexpressing receptors, as well as formulating stable pure protein, are contributing to the growing interest in targeting GPCRs with antibodies. This review discusses the opportunities for targeting GPCRs with antibodies using these approaches and describes the therapeutic antibodies that are currently in clinical development.Key words: G protein-coupled receptor, transmembrane spanning domain, chemokine receptor, extracellular domain, extracellular loop 相似文献
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65.
M. R. Hutchings I. Kyriazakis T. G. Papachristou I. J. Gordon F. Jackson 《Oecologia》2000,124(2):242-251
An experiment was carried out using a trade-off framework to determine the rules of sward selection, in relation to gastrointestinal
parasite dispersion, used by mammalian herbivores, and the effect of level of feeding motivation and parasitic status on these
rules. Twenty-four sheep divided into four animal treatment groups resulting from two levels of feeding motivation (high and
moderate) and two parasitic states (parasitised with Ostertagia circumcincta and non-parasitised) were presented with pairs of experimental swards which varied in N content (high and low), sward height
(tall and short) and level of contamination with faeces and thus parasites (contaminated and non-contaminated). The selection
for tall swards outweighed both the selection for N-rich swards and the avoidance of faecal contaminated swards. The selection
for N-rich swards could not completely overcome faecal avoidance. Parasitism in animals with a moderate feeding motivation
reduced their bite rates and grazing depths, thereby probably reducing the rate of ingestion of parasitic larvae. In contrast,
highly feeding-motivated animals (including those parasitised) increased their bite rates and grazing depths, thereby increasing
the rate of ingestion of parasites. The inclusion of parasite distributions, both in the environment and within herbivore
host populations, is likely to advance optimal foraging theory by enhancing its predictive power.
Received: 30 November 1999 / Accepted: 14 February 2000 相似文献
66.
J. Langbein ‡ M. R. Hutchings § S. Harris C. Stoate † S. C. Tapper† S. Wray 《Mammal Review》1999,29(2):93-116
Over the last few decades, there have been significant declines in Brown Hare Lepus europaeus numbers throughout Europe, leading to concern for their status in many countries. In Britain, there were no quantified data on the extent of this decline, on current population levels, or any baseline against which to monitor future population changes. The need for a quantified national hare survey led to this evaluation of the techniques available to assess hare numbers. Published information on counting hares is reviewed, and various techniques compared by applying them to a number of sites in southern England. Three basic approaches are available: counts of inactive hares, counts of active hares and indirect methods. Counts of inactive hares include total clearance, wide belt and line transect counts. Total clearance counts give an absolute figure, but are labour intensive and can only be applied to restricted areas. Wide-belt assessments are difficult to apply in certain habitats and even in open areas tend to produce a substantial over-estimate. Line transect counts are easy to undertake and are not labour intensive but should only be applied to large areas, or data from several small areas combined. Counts based on active hares are more problematical, because it is difficult to determine what proportion of the population is inactive at any one time. Spotlight counts based on variable circular plots are the most accurate but difficult to apply widely, and twilight counts are very subjective in their interpretation, especially when surveying small areas or areas with a large proportion of concealing habitats. Of the indirect methods, dung pellet counts can be valuable in specific areas but are difficult to apply across a range of habitats. We concluded that, of the various techniques considered, line transect counts have the greatest potential for a national survey, but need to be stratified so that enough transects are undertaken within each habitat stratum to obtain a reliable mean population estimate for each stratum. 相似文献
67.
Sara L Goodacre Oliver Y Martin Dries Bonte Linda Hutchings Chris Woolley Kamal Ibrahim CF George Thomas Godfrey M Hewitt 《BMC biology》2009,7(1):32-8
Background
Dispersal plays a key role in shaping biological and ecological processes such as the distribution of spatially-structured populations or the pace and scale of invasion. Here we have studied the relationship between long-distance dispersal behaviour of a pest-controlling money spider,Erigone atra, and the distribution of maternally acquired endosymbionts within the wider meta-population. This spider persists in heterogeneous environments because of its ability to recolonise areas through active long-distance airborne dispersal using silk as a sail, in a process termed 'ballooning'. 相似文献68.
69.
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