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81.
Methylglyoxal‐induced apoptosis is dependent on the suppression of c‐FLIPL expression via down‐regulation of p65 in endothelial cells 下载免费PDF全文
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Vascular endothelial cells: Targets for studying the activity of hair follicle cell-produced VEGF 总被引:1,自引:0,他引:1
S. Lachgar M. Charvéron Y. Gall J. Plouët J. L. Bonafé 《Cell biology and toxicology》1996,12(4-6):331-334
Fetal bovine aortic endothelial cells (FBAEC) were exposed to purified fractions of conditioned medium from cultures of hair dermal papilla cells (DPC) to determine the existence of any vascular endothelial growth factor (VEGF)-like paracrine activity of the latter. Such fractions were tested for stimulation of growth and migration of cultured FBAEC. In addition, VEGF secretion by DPC was measured by radioassay of VEGF receptors using FBAEC as target cells. The results showed that stimulation of FBAEC proliferation and migration following exposure to purified conditioned medium was dose-dependent. Radioreceptor assays of recombinant VEGF and purified DPC-conditioned medium showed competitive VEGF binding in FBAEC.Abbreviations CM
conditioned medium
- DMEM
Dulbecco's modified eagle's medium
- DPC
dermal papilla cells
- EDTA
ethylenediaminetetra-acetic acid
- FBAEC
fetal bovine aortic endothelial cells
- FCS
fetal calf serum
- VEGF
vascular endothelial growth factor 相似文献
84.
K. Böjthe-Horváth F. Hetényi Á. Kocsis L. Szabó M. Varga-Balázs I. Máthé P. Tétényi 《Phytochemistry》1980,21(12):2917-2919
From the aerial parts of Galium verum in flower, asperuloside and V1 iridoid were isolated. From the mother liquor obtained on recrystallizatio 相似文献
85.
Juaristi Inés Contreras Laura González-Sánchez Paloma Pérez-Liébana Irene González-Moreno Luis Pardo Beatriz del Arco Araceli Satrústegui Jorgina 《Neurochemical research》2019,44(10):2385-2391
Neurochemical Research - The brain uses mainly glucose as fuel with an index of glucose to oxygen utilization close to 6, the maximal index if all glucose was completely oxidized. However, this... 相似文献
86.
Říčan Oldřich Říčanová Štěpánka Dragová Klára Piálek Lubomír Almirón Adriana Casciotta Jorge 《Hydrobiologia》2019,832(1):331-354
Hydrobiologia - We address the diversity of two species groups of the cichlid genus Gymnogeophagus in the Middle Paraná basin using molecular phylogeography and traditional morphological... 相似文献
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Background
Pancreatic-tail duct ligation (PDL) in adult rodents has been reported to induce beta cell generation and increase beta cell mass but increases in beta cell number have not been demonstrated. This study examines whether PDL increases beta cell number and whether this is caused by neogenesis of small clusters and/or their growth to larger aggregates.Methodology
Total beta cell number and its distribution over small (<50 µm), medium, large (>100 µm) clusters was determined in pancreatic tails of 10-week-old mice, 2 weeks after PDL or sham.Principal findings
PDL increased total beta cell mass but not total beta cell number. It induced neogenesis of small beta cell clusters (2.2-fold higher number) which contained a higher percent proliferating beta cells (1.9% Ki67+cells) than sham tails (<0.2%); their higher beta cell number represented <5% of total beta cell number and was associated with a similar increase in alpha cell number. It is unknown whether the regenerative process is causally related to the inflammatory infiltration in PDL-tails. Human pancreases with inflammatory infiltration also exhibited activation of proliferation in small beta cell clusters.Conclusions/significance
The PDL model illustrates the advantage of direct beta cell counts over beta cell mass measurements when assessing and localizing beta cell regeneration in the pancreas. It demonstrates the ability of the adult mouse pancreas for neogenesis of small beta cell clusters with activated beta cell proliferation. Further studies should investigate conditions under which neoformed small beta cell clusters grow to larger aggregates and hence to higher total beta cell numbers. 相似文献89.