全文获取类型
收费全文 | 156003篇 |
免费 | 24232篇 |
国内免费 | 11771篇 |
专业分类
192006篇 |
出版年
2024年 | 312篇 |
2023年 | 1794篇 |
2022年 | 3915篇 |
2021年 | 6779篇 |
2020年 | 6228篇 |
2019年 | 8690篇 |
2018年 | 8504篇 |
2017年 | 7618篇 |
2016年 | 9231篇 |
2015年 | 11716篇 |
2014年 | 12843篇 |
2013年 | 13875篇 |
2012年 | 13956篇 |
2011年 | 12534篇 |
2010年 | 9779篇 |
2009年 | 7943篇 |
2008年 | 7967篇 |
2007年 | 6849篇 |
2006年 | 6099篇 |
2005年 | 4987篇 |
2004年 | 4319篇 |
2003年 | 3898篇 |
2002年 | 3384篇 |
2001年 | 2473篇 |
2000年 | 2146篇 |
1999年 | 2061篇 |
1998年 | 1305篇 |
1997年 | 1219篇 |
1996年 | 1102篇 |
1995年 | 954篇 |
1994年 | 914篇 |
1993年 | 738篇 |
1992年 | 933篇 |
1991年 | 723篇 |
1990年 | 571篇 |
1989年 | 516篇 |
1988年 | 408篇 |
1987年 | 396篇 |
1986年 | 323篇 |
1985年 | 356篇 |
1984年 | 218篇 |
1983年 | 203篇 |
1982年 | 139篇 |
1981年 | 131篇 |
1980年 | 95篇 |
1979年 | 113篇 |
1978年 | 71篇 |
1977年 | 85篇 |
1975年 | 69篇 |
1973年 | 78篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
991.
992.
Li J Ji C Zheng H Fei X Zheng M Dai J Gu S Xie Y Mao Y 《Cellular & molecular biology letters》2005,10(1):185-193
Ankyrin repeat, one of the most important protein motifs, plays a wide variety of roles in protein-protein interactions and in the signal pathways. Via large-scale sequencing, a novel 941-bp gene was isolated from an 18-week old human fetal brain cDNA library. It encodes a putative protein of 158 amino acid residues with four conserved ankyrin repeat domains. It displays a high degree of homology with rat low-density lipoprotein receptor-related protein 2-binding protein (Lrp2bp), and was therefore was named hLrp2bp (human Lrp2bp). The hLrp2bp gene was located in chromosome 4q35 and the conserved ankyrin repeat domains were located between amino acid residues 10 and 116. RT-PCR revealed that hLrp2bp was mainly expressed in the human testis, small intestine, colon and blood leukocytes, and in human pancreatic adenocarcinoma cells. A HEK293 cell was transfected with the ORF of hLrp2bp, and analyses showed that the protein was distributed both in the cytoplasm and nucleus. 相似文献
993.
994.
995.
996.
997.
998.
Chiakang Ho Ya Gao Danning Zheng Yanjun Liu Shengzhou Shan Bin Fang Yixuan Zhao Dingzhong Song Yifan Zhang Qingfeng Li 《Journal of cellular and molecular medicine》2019,23(8):5108-5118
Obesity and its associated metabolic disorders such as diabetes, hepatic steatosis and chronic heart diseases are affecting billions of individuals. However there is no satisfactory drug to treat such diseases. In this study, we found that alisol A, a major active triterpene isolated from the Chinese traditional medicine Rhizoma Alismatis, could significantly attenuate high‐fat‐diet‐induced obesity. Our biochemical detection demonstrated that alisol A remarkably decreased lipid levels, alleviated glucose metabolism disorders and insulin resistance in high‐fat‐diet‐induced obese mice. We also found that alisol A reduced hepatic steatosis and improved liver function in the obese mice model.In addition, protein expression investigation revealed that alisol A had an active effect on AMPK/ACC/SREBP‐1c pathway. As suggested by the molecular docking study, such bioactivity of alisol A may result from its selective binding to the catalytic region of AMPK.Therefore, we believe that Alisol A could serve as a promising agent for treatment of obesity and its related metabolic diseases. 相似文献
999.
1000.
The p38 mitogen-activated protein kinase (MAPK) is involved in various processes, including stress responses, development, and differentiation. However, little information on p38 MAPK in insects is available. In this study, a p38 MAPK gene, Accp38b, was isolated from Apis cerana cerana and characterized. The quantitative real-time PCR (Q-PCR) analysis revealed that Accp38b was induced by multiple stressors. Notably, the expression of Accp38b was relatively higher in the pupae phase than in other developmental phases. During the pupae phase, Accp38b expression was higher in the thorax than in the head and abdomen and higher in the fat body than in the muscle and midgut. Immunohistochemisty showed significant positive staining of Accp38b in sections from the brain, eyes, fat body, and midgut of A. cerana cerana. These results suggest that Accp38b may play a crucial role in stress responses and have multiple aspects function during development. 相似文献