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Schmid AK Lipton MS Mottaz H Monroe ME Smith RD Lidstrom ME 《Journal of proteome research》2005,4(3):709-718
The results of previous studies indicated that D. radiodurans mounts a regulated protective response to heat shock, and that expression of more than 130 genes, including classical chaperones such as the groESL and dnaKJ operons and proteases such as clpB are induced in response to elevated temperature. In addition, previous qualitative whole-cell mass spectrometric studies conducted under heat shock conditions indicated global changes in the D. radiodurans proteome. To enable the discovery of novel heat shock inducible proteins as well as gain greater biological insight into the classical heat shock response at the protein level, we undertook the global whole-cell FTICR mass spectrometric proteomics study reported here. We have greatly increased the power of this approach by conducting a large number of replicate experiments in addition to taking a semiquantitative approach to data analysis, finding good reproducibility between replicates. Through this analysis, we have identified with high confidence a core set of classical heat shock proteins whose expression increases dramatically and reproducibly in response to elevated temperature. In addition, we have found that the heat shock proteome includes a large number of induced proteins that have not been identified previously as heat responsive, and have therefore been designated as candidate responders. Finally, our results are consistent with the hypothesis that elevated temperature stress could lead to cross-protection against other related stresses. 相似文献
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Ancient DNA Provides New Insights into the Evolutionary History of New Zealand's Extinct Giant Eagle
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Michael Bunce Marta Szulkin Heather R. L Lerner Ian Barnes Beth Shapiro Alan Cooper Richard N Holdaway 《PLoS biology》2005,3(1)
Prior to human settlement 700 years ago New Zealand had no terrestrial mammals—apart from three species of bats—instead, approximately 250 avian species dominated the ecosystem. At the top of the food chain was the extinct Haast's eagle, Harpagornis moorei. H. moorei (10–15 kg; 2–3 m wingspan) was 30%–40% heavier than the largest extant eagle (the harpy eagle, Harpia harpyja), and hunted moa up to 15 times its weight. In a dramatic example of morphological plasticity and rapid size increase, we show that the H. moorei was very closely related to one of the world's smallest extant eagles, which is one-tenth its mass. This spectacular evolutionary change illustrates the potential speed of size alteration within lineages of vertebrates, especially in island ecosystems. 相似文献
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Bedell JA Budiman MA Nunberg A Citek RW Robbins D Jones J Flick E Rholfing T Fries J Bradford K McMenamy J Smith M Holeman H Roe BA Wiley G Korf IF Rabinowicz PD Lakey N McCombie WR Jeddeloh JA Martienssen RA 《PLoS biology》2005,3(1):e13
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