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41.
Bell JR Porrello ER Huggins CE Harrap SB Delbridge LM 《American journal of physiology. Heart and circulatory physiology》2008,294(4):H1514-H1522
Important sex differences in cardiovascular disease outcomes exist, including conditions of hypertrophic cardiomyopathy and cardiac ischemia. Studies of sex differences in the extent to which load-independent (primary) hypertrophy modulates the response to ischemia-reperfusion (I/R) damage have not been characterized. We have previously described a model of primary genetic cardiac hypertrophy, the hypertrophic heart rat (HHR). In this study the sex differences in HHR cardiac function and responses to I/R [compared to control normal heart rat (NHR)] were investigated ex vivo. The ventricular weight index was markedly increased in HHR female (7.82 +/- 0.49 vs. 4.80 +/- 0.10 mg/g; P < 0.05) and male (5.76 +/- 0.22 vs. 4.62 +/- 0.07 mg/g; P < 0.05) hearts. Female hearts of both strains exhibited a reduced basal contractility compared with strain-matched males [maximum first derivative of pressure (dP/dt(max)): NHR, 4,036 +/- 171 vs. 4,258 +/- 152 mmHg/s; and HHR, 3,974 +/- 160 vs. 4,540 +/- 259 mmHg/s; P < 0.05]. HHR hearts were more susceptible to I/R (I = 25 min, and R = 30 min) injury than NHR hearts (decreased functional recovery, and increased lactate dehydrogenase efflux). Female NHR hearts exhibited a significantly greater recovery (dP/dt(max)) post-I/R relative to male NHR (95.0 +/- 12.2% vs. 60.5 +/- 9.4%), a resistance to postischemic dysfunction not evident in female HHR (29.0 +/- 5.6% vs. 25.9 +/- 6.3%). Ventricular fibrillation was suppressed, and expression levels of Akt and ERK1/2 were selectively elevated in female NHR hearts. Thus the occurrence of load-independent primary cardiac hypertrophy undermines the intrinsic resistance of female hearts to I/R insult, with the observed abrogation of endogenous cardioprotective signaling pathways consistent with a potential mechanistic role in this loss of protection. 相似文献
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Pamela B. Moore Darrell R. Anderson John W. Huggins Kermit L. Carraway 《Biochemical and biophysical research communications》1976,72(1):288-294
Membrane envelopes prepared from Zn++-treated Sarcoma 180 cells contain polypeptides which appear to be related to the putative cellular cytoskeletal elements responsible for control of cell shape and motility. These include actin, myosin, α-actinin and a large polypeptide (mol wt 250,000) with some similarities to spectrin of the erythrocyte membrane. If the envelopes are vesiculated by extraction with alkaline EDTA solutions at low ionic strength, four major polypeptides are released, including the actin and spectrin-like materials; myosin is not extracted. The stabilized envelopes offer a useful source of material for the characterization of cytoskeletal elements and for the investigation of their associations with the membrane. 相似文献
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Anomalous staining of membrane lipids on acrylamide gels 总被引:4,自引:0,他引:4
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