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51.
When physiological adaptation is insufficient, hosts have developed behavioral responses to avoid or limit contact with parasites. One such behavior, leaf-swallowing, occurs widely among the African great apes. This behavior involves the slow and deliberate swallowing without chewing of whole bristly leaves. Folded one at a time between tongue and palate, the leaves pass through the gastro-intestinal (GI) tract visibly unchanged. Independent studies in two populations of chimpanzees (Pan troglodytes schweinfurthii) showed significant correlations between the swallowing of whole leaves and the expulsion of the nodule worm Oesophagostomum stephanostomum and a species of tapeworm (Bertiella studeri). We integrate behavioral, parasitological and physiological observations pertaining to leaf-swallowing to elucidate the behavioral mechanism responsible for the expulsion and control of nodule worm infections by the ape host. Physical irritation produced by bristly leaves swallowed on an empty stomach, increases motility and secretion resulting in diarrhea which rapidly moves leaves through the GI tract. In the proximal hindgut, the site of third-stage larvae (L3) cyst formation and adult worm attachment, motility, secretion and the scouring effect of rough leaves is enhanced by haustral contractions and peristalsis-antiperistalsis. Frequently, at the peak of reinfection, a proportion of nonencysted L3 is also predictably vulnerable. These factors should result in the disruption of the life cycle of Oesophagostomum spp. Repeated flushing during peak periods of reinfection is probably responsible for long-run reduction of worm burdens at certain times of the year. Accordingly, leaf-swallowing can be viewed as a deliberate adaptive behavioral strategy with physiological consequences for the host. The expulsion of worms based on the activation of basic physiological responses in the host is a novel hitherto undescribed form of parasitic control. 相似文献
52.
Takahata Yukio Huffman Michael A. Bardi Massimo 《International journal of primatology》2002,23(2):399-410
In a long-term study of sexual behavior in Japanese macaques, we found that matrilineal inbreeding accounted for 2.9% of the copulations recorded for the Arashiyama B troop during 7 mating seasons between 1968 and 1984. Of the 906 copulatory dyads, 46 (5.1%) occurred among kin. Close matrilineal kin dyads (r = 1/2–1/8, 1.1% of the total of copulatory dyads) strongly avoided matrilineal inbreeding, but for remote kin dyads (r > 1/8, 4.0% of the total) the tendency was weaker in some years. Among the possible determinants of matrilineal inbreeding, we found that it tended to occur among younger and lower-ranking males as an effect of troop demographic changes. There is no significant association between female rank and matrilineal inbreeding. Our results are consistent with the hypothesis that different degrees of kin relatedness are discriminated by individuals with respect to mate choice. 相似文献
53.
John W. Huffman Simon M. Bushell John R. A. Miller Jenny L. Wiley Billy R. Martin 《Bioorganic & medicinal chemistry》2002,10(12):7809
Three series of new cannabinoids were prepared and their affinities for the CB1 and CB2 cannabinoid recptors were determined. These are the 1-methoxy-3-(1′,1′-dimethylalkyl)-, 1-deoxy-11-hydroxy-3-(1′,1′-dimethylalkyl)- and 11-hydroxy-1-methoxy-3-(1′,1′-dimethylalkyl)-Δ8-tetrahydrocannabinols, which contain alkyl chains from dimethylethyl to dimethylheptyl appended to C-3 of the cannabinoid. All of these compounds have greater affinity for the CB2 receptor than for the CB1 receptor, however only 1-methoxy-3-(1′,1′-dimethylhexyl)-Δ8-THC (JWH-229, 6e) has effectively no affinity for the CB1 receptor (Ki=3134±110 nM) and high affinity for CB2 (Ki=18±2 nM). 相似文献
54.
In this study, we monitored episodic luteinizing hormone (LH) secretion throughout development in eight April-born ewe lambs to determine if a change in LH pulse patterns preceded first ovulation at puberty. LH pulses were measured in samples collected every 12 min for 6 h once in July, twice a month from 22 August to 2 October, and then weekly until puberty. Progesterone concentrations, measured in samples taken 3/wk, were used as an index of first ovulation, which occurred at 29.3 +/- 0.7 wk of age. LH pulse frequencies throughout most of this period ranged from 0 to 2 pulses/6 h, with no change over time. However, during the week prior to the first progesterone rise, there was a significant increase in pulse frequency to a level seen during the follicular phase in post-pubertal lambs. This increase in pulse frequency was evident in 7 of 8 lambs; pulses were not analyzed in the last lamb because samples were taken during the LH surge. In contrast, LH pulse amplitude did not increase prior to puberty. In fact, pulse amplitude declined linearly during the 3 wk before first ovulation and then increased during the follicular phase in post-pubertal animals. These results support the hypothesis that an increase in the frequency of episodic LH secretion is a key event leading to the onset of ovarian cycles in the lamb. Whether an increase in pulse amplitude is also necessary remains unclear. If so, it must occur just before the LH surge, since it was not detected in any samples taken before puberty in this study. 相似文献
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56.
Quantitative evaluation of health impairments in wild chimpanzees was explored using fractal long‐range correlations of behavioural sequences. The health status of 13 chimpanzees in the Mahale Mountains National Park, Tanzania was evaluated non‐invasively using standard behavioural observation and parasitological analysis of stool samples. Based on these data, individuals were classified as being either healthy or sick. Behavioural sequences were analysed and shown to exhibit long‐range power law correlations. The behavioural sequences of individuals in healthy and sick states were quantitatively evaluated using detrended fluctuation analysis of social and non‐social behaviours within behavioural sequences. These values were compared and significant differences in long‐range correlations were found between health states. Sex differences were also noted, with female social behaviour displaying a larger fractal dimension than male social behaviour. The fractal dimension of females declined significantly in sick individuals. This analysis of behaviour provides a new and effective non‐invasive method to record and evaluate the general state of health and related stress of animals in the wild. Possible applications of this method in captive situations include the monitoring and evaluating of stress levels over time. 相似文献
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58.
Zaira Aversa Thomas A. White Amanda A. Heeren Cassondra A. Hulshizer Dominik Saul Xu Zhang Anthony J. A. Molina Leanne M. Redman Corby K. Martin Susan B. Racette Kim M. Huffman Manjushri Bhapkar Sundeep Khosla Sai Krupa Das Roger A. Fielding Elizabeth J. Atkinson Nathan K. LeBrasseur 《Aging cell》2024,23(2):e14038
Calorie restriction (CR) with adequate nutrient intake is a potential geroprotective intervention. To advance this concept in humans, we tested the hypothesis that moderate CR in healthy young-to-middle-aged individuals would reduce circulating biomarkers of cellular senescence, a fundamental mechanism of aging and aging-related conditions. Using plasma specimens from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) phase 2 study, we found that CR significantly reduced the concentrations of several senescence biomarkers at 12 and 24 months compared to an ad libitum diet. Using machine learning, changes in biomarker concentrations emerged as important predictors of the change in HOMA-IR and insulin sensitivity index at 12 and 24 months, and the change in resting metabolic rate residual at 12 months. Finally, using adipose tissue RNA-sequencing data from a subset of participants, we observed a significant reduction in a senescence-focused gene set in response to CR at both 12 and 24 months compared to baseline. Our results advance the understanding of the effects of CR in humans and further support a link between cellular senescence and metabolic health. 相似文献
59.
Geographic isolation facilitates the evolution of reproductive isolation and morphological divergence 下载免费PDF全文
McLean L. D. Worsham Eric P. Julius Chris C. Nice Peter H. Diaz David G. Huffman 《Ecology and evolution》2017,7(23):10278-10288
Geographic isolation is known to contribute to divergent evolution, resulting in unique phenotypes. Oftentimes morphologically distinct populations are found to be interfertile while reproductive isolation is found to exist within nominal morphological species revealing the existence of cryptic species. These disparities can be difficult to predict or explain especially when they do not reflect an inferred history of common ancestry which suggests that environmental factors affect the nature of ecological divergence. A series of laboratory experiments and observational studies were used to address what role biogeographic factors may play in the ecological divergence of Hyalella amphipods. It was found that geographic isolation plays a key role in the evolution of reproductive isolation and divergent morphology and that divergence cannot be explained by molecular genetic variation. 相似文献
60.
Muzumdar R Allison DB Huffman DM Ma X Atzmon G Einstein FH Fishman S Poduval AD McVei T Keith SW Barzilai N 《Aging cell》2008,7(3):438-440
Caloric restriction (CR) can delay many age-related diseases and extend lifespan, while an increase in adiposity is associated with enhanced disease risk and accelerated aging. Among the various fat depots, the accrual of visceral fat (VF) is a common feature of aging, and has been shown to be the most detrimental on metabolic syndrome of aging in humans. We have previously demonstrated that surgical removal of VF in rats improves insulin action; thus, we set out to determine if VF removal affects longevity. We prospectively studied lifespan in three groups of rats: ad libitum-fed (AL-fed), CR (Fed 60% of AL) and a group of AL-fed rats with selective removal of VF at 5 months of age (VF-removed rats). We demonstrate that compared to AL-fed rats, VF-removed rats had a significant increase in mean (p < 0.001) and maximum lifespan (p < 0.04) and significant reduction in the incidence of severe renal disease (p < 0.01). CR rats demonstrated the greatest mean and maximum lifespan (p < 0.001) and the lowest rate of death as compared to AL-fed rats (0.13). Taken together, these observations provide the most direct evidence to date that a reduction in fat mass, specifically VF, may be one of the possible underlying mechanisms of the anti-aging effect of CR. 相似文献