Cylindrically Rotatable Designs of Type 3: Further Considerations

The cylindrically rotatable designs of type 3 are generalised to consider the factors split up into any number of groups. The conditions which must be satisfied by such a design are derived from the moment generating function of the design. A method of construction of second-order cylindrically rotatable designs of type 3 with three or more groups of factors is provided.     

Some Third-Order Rotatable Designs

Some new third-order rotatable designs are obtained in 5, 6, 7 and 8 dimensions. Many of these designs are of a sequential type and some require fewer experiments than the known designs with minimal number of experiments.     

Behavioral effects of dynorphin1–13 in the mouse and rat: Initial observations

Dynorphin is a recently identified, pharmacologically potent endogenous opioid peptide. Heretofore it has not been characterized for its behavioral effects. The effects of centrally infused dynorphin upon a variety of behaviors were therefore examined in mice and rats. The present findings point to a specific profile of behavioral activity. The peptide was active in facilitating feeding and grooming, but was inactive in modifying pain sensitivity and rearing behavior. Naloxone was generally ineffective in reversing behavioral effects. Dynorphin thus appears to have some opiate-like effects upon exogenous administration but may be rapidly broken down into a behaviorally potent non-opiate peptide fragment.