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171.
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EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
Jeremiah J Bearss Sathish KR Padi Neha Singh Marina CardoVila Jin H Song Ghassan Mouneimne Nikita Fernandes Yang Li Matthew R Harter Jaime MC Gard Anne E Cress Wolfgang Peti Andrew DL Nelson J Ross Buchan Andrew S Kraft Koichi Okumura 《EMBO reports》2021,22(4)
Regulation of mRNA stability and translation plays a critical role in determining protein abundance within cells. Processing bodies (P‐bodies) are critical regulators of these processes. Here, we report that the Pim1 and 3 protein kinases bind to the P‐body protein enhancer of mRNA decapping 3 (EDC3) and phosphorylate EDC3 on serine (S)161, thereby modifying P‐body assembly. EDC3 phosphorylation is highly elevated in many tumor types, is reduced upon treatment of cells with kinase inhibitors, and blocks the localization of EDC3 to P‐bodies. Prostate cancer cells harboring an EDC3 S161A mutation show markedly decreased growth, migration, and invasion in tissue culture and in xenograft models. Consistent with these phenotypic changes, the expression of integrin β1 and α6 mRNA and protein is reduced in these mutated cells. These results demonstrate that EDC3 phosphorylation regulates multiple cancer‐relevant functions and suggest that modulation of P‐body activity may represent a new paradigm for cancer treatment. 相似文献
173.
Sarah Habran Cathy Debier Daniel E. Crocker Dorian S. Houser Gilles Lepoint Jean-Marie Bouquegneau Krishna Das 《Marine Mammal Science》2010,26(4):880-895
Effects of physiological processes such as gestation, lactation and nutritional stress on stable isotope ratios remain poorly understood. To determine their impact, we investigated these processes in simultaneously fasting and lactating northern elephant seals (Mirounga angustirostris). Stable carbon and nitrogen isotope values were measured in blood and milk of 10 mother-pup pairs on days 5 and 22 of lactation. As long- and short-term integrators of diet, blood cells and serum may reflect foraging data or energy reserves from late gestation and lactation, respectively. Limited changes in isotopic signatures of maternal blood over the lactating period were highlighted. Nitrogen isotope fractionation associated with mother-to-offspring transfer of nutrients was generated between mother and offspring during gestation and lactation. This fractionation was tissue and time-specific, it varied between early and late lactation from +0.6‰ to +1.3‰ in blood cells and from +1.1‰ to nonsignificant value in serum. Therefore, if pups appear to be good proxies to investigate the female trophic ecology especially for C sources, much more caution is required in using δ15N values. Further studies are also needed to better define the relative impact of fasting and lactation on the enrichment or depletion of isotopes in different tissues. 相似文献
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Prompted progression order in a troop of captive rhesus monkeys 总被引:1,自引:0,他引:1
V Reinhardt A Reinhardt D Houser 《Folia primatologica; international journal of primatology》1987,48(3-4):121-124
It is a routine practice to subject captive groups of primates to single-file movement; yet no records on the sequences of such progressions have been published. The present study analyzes the progression sequence during prompted single-file movement for the purpose of routine weighing in a captive troop of rhesus monkeys (Macaca mulatta). The animals had to overcome fear before leaving their home pen; nonetheless, they left in a well-defined, stable sequence. An individual's position in this progression order as well as the consistency with which it retained its place were dependent on its age but not on its dominance status. It was suggested that the monkeys gradually learned with age to master their fear with the prospect of quickly returning to their home pen. 相似文献