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61.
J. L. Horner 《BMJ (Clinical research ed.)》1965,1(5430):317-318
62.
Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy 下载免费PDF全文
Luo J McMullen JR Sobkiw CL Zhang L Dorfman AL Sherwood MC Logsdon MN Horner JW DePinho RA Izumo S Cantley LC 《Molecular and cellular biology》2005,25(21):9491-9502
Class I(A) phosphoinositide 3-kinases (PI3Ks) are activated by growth factor receptors, and they regulate, among other processes, cell growth and organ size. Studies using transgenic mice overexpressing constitutively active and dominant negative forms of the p110alpha catalytic subunit of class I(A) PI3K have implicated the role of this enzyme in regulating heart size and physiological cardiac hypertrophy. To further understand the role of class I(A) PI3K in controlling heart growth and to circumvent potential complications from the overexpression of dominant negative and constitutively active proteins, we generated mice with muscle-specific deletion of the p85alpha regulatory subunit and germ line deletion of the p85beta regulatory subunit of class I(A) PI3K. Here we show that mice with cardiac deletion of both p85 subunits exhibit attenuated Akt signaling in the heart, reduced heart size, and altered cardiac gene expression. Furthermore, exercise-induced cardiac hypertrophy is also attenuated in the p85 knockout hearts. Despite such defects in postnatal developmental growth and physiological hypertrophy, the p85 knockout hearts exhibit normal contractility and myocardial histology. Our results therefore provide strong genetic evidence that class I(A) PI3Ks are critical regulators for the developmental growth and physiological hypertrophy of the heart. 相似文献
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BACKGROUND AND AIMS: Prunus, subgenus Padus, exhibits two completely different calcium oxalate crystal macropatterns in mature leaves. Foliar macropattern development has been described previously in P. virginiana, representing one version. Prunus serotina, in the group exhibiting the second macropattern, is described here. The goal was to describe developmental details for comparison with P. virginiana, and to extend the sparse current knowledge of crystal macropatterns. METHODS: Leaves at various developmental stages were removed from local trees and from herbarium specimens. Early leaf stages and freehand leaf and stem sections were mounted directly in aqueous glycerine; larger leaves were processed whole or in representative pieces in household bleach, dehydrated in alcohol/xylol, and mounted in Permount. Crystals were detected microscopically between crossed polarizers. KEY RESULTS: Bud scales have a dense druse population. Druses appear first at the stipule tip and proliferate basipetally but soon stop forming; growing stipules therefore have a declining density of druses. Druses appear at the tip of leaves <1 mm long, then proliferate basipetally in the midrib. Lamina druses appear in the distal marginal teeth of leaves 3 cm long; from here they proliferate basipetally and towards midrib along major veins. In about two-thirds-grown leaves (6-9 cm length) druses are all adaxial to veins of most orders; a shift occurs then to formation of prisms, which appear first abaxial to, then all around, veins. Mature leaves have virtually all prisms encrusting all major veins, more sparsely along smaller minor veins. Late season leaves form epitactic crystals on existing prismatics. CONCLUSIONS: The developing and mature macropattern of P. serotina is almost the reverse of the pattern described previously in P. virginiana, and shows that two closely related species can develop radically different modes of crystallization. The few detailed macropattern studies to date reveal striking variations that indicate a new level of organization that must be integrated with the anatomical, physiological and molecular approaches that have been dominant so far. 相似文献
66.
Caribbean spiny lobsters display a diversity of social behaviors, one of the most prevalent of which is gregarious diurnal sheltering. Previous research has demonstrated that shelter selection is chemically mediated, but the source of release and the identity of the aggregation signal are unknown. In this study, we investigated the source and specificity of the aggregation signal in Caribbean spiny lobsters, Panulirus argus. We developed a relatively rapid test of shelter choice in a 5000-l laboratory flume that simulated flow conditions in the spiny lobster's natural environment, and used it to examine the shelter preference of the animals in response to a variety of odorants. We found that both males and females associated preferentially with shelters emanating conspecific urine of either sex, but not with shelters emanating seawater, food odors, or the scent of a predatory octopus. These results demonstrate specificity in the cues mediating sheltering behavior and show that urine is at least one source of the aggregation signal. 相似文献
67.
R. W. Thornburg C. Carter A. Powell R. Mittler L. Rizhsky H. T. Horner 《Plant Systematics and Evolution》2003,238(1-4):211-218
We have characterized the major nectar protein (Nectarin I) from ornamental tobacco as a superoxide dismutase that functions
to generate high levels of hydrogen peroxide in nectar. Other nectar functions include an anti-polygalacturonase activity
that may be due to a polygalacturonase inhibiting protein (PGIP). We also examined the expression of defense related genes
in the nectary gland by two independent methods. We isolated a sample of nectary-expressed cDNAs and found that 21% of these
cDNAs were defense related clones. Finally, we examined the expression of a number of specific defense-related genes by hybridization
to specific cDNAs. These results demonstrated that a number of specific defense genes were more strongly expressed in the
floral nectary than in the foliage. Taken together these results indicate that the floral nectary gland can have specific
functions in plant defense.
Received August 8, 2002; accepted January 7, 2003
Published online: June 2, 2003 相似文献
68.
J Servière K C Horner C Granier-Deferre 《Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie》1986,302(1):37-42
Pregnant guinea pigs injected with 2-DG between 10 to 2 days before birth, were exposed to loud free field pure tones (nine frequencies tested from 0.8 to 20 kHz). Specific bands of labeling were observed in the Inferior Colliculi of most of the fetuses whatever the frequency tested. The location of these isofrequency laminae shifted with stimulus frequency, their orientation were similar to those observed in the mothers. No such bands were found either in the control females or their fetuses. These results demonstrate that the auditory system of the fetus responds to frequencies up to 20 kHz, exhibits frequency selectivity and tonotopic organization in utero. 相似文献
69.
The nature of two components of pig mucosal heparin, separated by electrophoresis in agarose gel 总被引:1,自引:0,他引:1
A A Horner 《Canadian journal of biochemistry》1967,45(7):1015-1020
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