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821.
Horacio G. Rotstein 《Journal of computational neuroscience》2017,42(2):133-166
The generation of intrinsic subthreshold (membrane potential) oscillations (STOs) in neuronal models requires the interaction between two processes: a relatively fast positive feedback that favors changes in voltage and a slower negative feedback that opposes these changes. These are provided by the so-called resonant and amplifying gating variables associated to the participating ionic currents. We investigate both the biophysical and dynamic mechanisms of generation of STOs and how their attributes (frequency and amplitude) depend on the model parameters for biophysical (conductance-based) models having qualitatively different types of resonant currents (activating and inactivating) and an amplifying current. Combinations of the same types of ionic currents (same models) in different parameter regimes give rise to different types of nonlinearities in the voltage equation: quasi-linear, parabolic-like and cubic-like. On the other hand, combinations of different types of ionic currents (different models) may give rise to the same type of nonlinearities. We examine how the attributes of the resulting STOs depend on the combined effect of these resonant and amplifying ionic processes, operating at different effective time scales, and the various types of nonlinearities. We find that, while some STO properties and attribute dependencies on the model parameters are determined by the specific combinations of ionic currents (biophysical properties), and are different for models with different such combinations, others are determined by the type of nonlinearities and are common for models with different types of ionic currents. Our results highlight the richness of STO behavior in single cells as the result of the various ways in which resonant and amplifying currents interact and affect the generation and termination of STOs as control parameters change. We make predictions that can be tested experimentally and are expected to contribute to the understanding of how rhythmic activity in neuronal networks emerge from the interplay of the intrinsic properties of the participating neurons and the network connectivity. 相似文献
822.
Cecilia Smith-Ramírez Iván Díaz Patricio Pliscoff Claudio Valdovinos Marco A. Méndez Juan Larraín Horacio Samaniego 《Biodiversity and Conservation》2007,16(9):2627-2648
Knowledge of species richness centers is necessary for the design of conservation areas. In this study, we present a GIS analysis
of two years of field data on animal and plant diversity distributions in evergreen, coastal rain forests of southern Chile
(39°30′–41°25′ S). Despite their high endemism, these forests have remained largely unprotected. Field records were complemented
with data from museum collections and scientific literature. We used selected environmental variables (evapotranspiration,
altitude) and, in some cases, forest types as predictors of species distributions. Our study focused on the distribution of
forest bryophytes, vascular plants, soil invertebrates, amphibians and birds. We generated distributional maps for each taxa
based on their field records in the study area, complemented by natural history information, except in the case of bryophytes
and soil invertebrates. In general, species richness was lower at 600 m elevation or above for all the taxa studied. Species
richness tends to increase in the northern sector of the study area. We observed a greater richness of vascular plants near
rivers and streams, and noted important floristic differences between west and east-facing slopes of the Coastal Range, with
more species in the oriental side. Because species in high altitude forests are not a subset of those found at lower elevations,
we propose that conservation strategies should prioritize the protection of the entire altitudinal gradient of the southern
Coastal Range, especially in the more diverse oriental and northern sectors. 相似文献