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981.
Young Hoon Song Jeong Chan Park Chang Sup Kim Dong Soo Hwang Hyung Joon Cha Jeong Hyun Seo 《Biotechnology and Bioprocess Engineering》2018,23(3):341-348
Due to their environmental friendliness, woodbased biomass pellets are widely used as conventional fuel sources in daily life and in various industries. Durability and proper mechanical strength are important quality factors for practical applications of biomass pellets as they enable their easy handling, transportation, and storage. In the present study, to increase mechanical strength of sawdust biomass pellet fuels, sucrose was employed as a main binder material. In addition, calcium ions were included as cross-linkers, which improved capability of modified binders. Even though sucrose alone enabled production of pellets with comparatively high compressive strength, addition of several calcium-containing substances further improved mechanical properties of sawdust pellets. Interestingly, we found that a combination of sucrose with CaCl2 (acidic blended solution) decreased, whereas addition of CaO or Ca(OH)2 (basic blended solution) considerably enhanced pellet strength. Thus, we concluded that calcium ions are able to form stable complexes with sucrose at basic pH levels (>10). Therefore, materials incorporating sucrose-calcium complexes can be successfully used as eco-friendly novel binders for the construction of durable biomass pellet fuels. Furthermore, their applications can be extended to formulations of nutritional or pharmaceutical substances. 相似文献
982.
Havid Aqoma Muhibullah Al Mubarok Wooseop Lee Wisnu Tantyo Hadmojo Cheolwoo Park Tae Kyu Ahn Du Yeol Ryu Sung‐Yeon Jang 《Liver Transplantation》2018,8(23)
High‐efficiency solid‐state‐ligand‐exchange (SSE) step‐free colloidal quantum dot photovoltaic (CQDPV) devices are developed by employing CQD ink based active layers and organic (Polythieno[3,4‐b]‐thiophene‐co‐benzodithiophene (PTB7) and poly(3‐hexylthiophene) (P3HT)) based hole transport layers (HTLs). The device using PTB7 as an HTL exhibits superior performance to that using the current leading organic HTL, P3HT, because of favorable energy levels, higher hole mobility, and facilitated interfacial charge transfer. The PTB7 based device achieves power conversion efficiency (PCE) of 9.60%, which is the highest among reported CQDPVs using organic HTLs. This result is also comparable to the PCE of an optimized device based on a thiol‐exchanged p‐type CQD, the current‐state‐of‐the‐art HTL. From the viewpoint of device processing, the fabrication of CQDPVs is achieved by direct single‐coating of CQD active layers and organic HTLs at low temperature without SSE steps. The experimental results and device simulation results in this work suggest that further engineering of organic HTL materials can open new doors to improve the performance and processing of CQDPVs. 相似文献
983.
Large‐Scale Conductive Yarns Based on Twistable Korean Traditional Paper (Hanji) for Supercapacitor Applications: Toward High‐Performance Paper Supercapacitors 下载免费PDF全文
Young‐Jung Heo Ji Won Lee Yeong‐Rae Son Jong‐Hoon Lee Chang Su Yeo Tran Dai Lam Sang Yoon Park Soo‐Jin Park Le Hoang Sinh Min Kyoon Shin 《Liver Transplantation》2018,8(27)
A simple and scalable method to fabricate a yarn‐type supercapacitor with a large specific capacitance without the aid of traditional pseudocapacitive electrode materials such as conducting polymers and metal oxides is reported. The yarn‐type supercapacitors are made from twisting reduced graphene oxide (rGO) or/and single‐walled carbon nanotubes (SWNTs)‐coated Korean traditional paper (KTP). The yarn‐type paper supercapacitor displays surprisingly enhanced electrochemical capacitance values, showing synergistic effect between rGO and SWNTs (500 times larger than performance of yarn‐type rGO‐coated paper supercapacitors). Coating rGO or/and SWNTs on KTP gives good morphology to the composite film, in which porosity increases and mean pore diameter decreases. The yarn‐type rGO/SWNT paper supercapacitor shows good mechanical strength, high flexibility, excellent electrochemical performance, and long‐life operation. The yarn‐type supercapacitor has an excellent electrochemical performance with a specific capacitance of 366 F g?1 at scan rate of 25 mV s?1 and high stability without any degradation in electrical performance up to 10 000 charge–discharge cycles. The average capacitance of rGO/SWNT@KTP yarn‐type supercapacitors is seven times higher than that of sheet‐type supercapacitors at scan rate of 500 mV s?1. The lighting of a red light‐emitting diode (LED) is demonstrated by the yarn‐type paper supercapacitor without connecting supercapacitors in series. 相似文献
984.
Superlattice Formation of Crystal Water in Layered Double Hydroxides for Long‐Term and Fast Operation of Aqueous Rechargeable Batteries 下载免费PDF全文
Ji Hoon Lee Hyeon Jeong Lee Sun Hee Choi Jaeho Shin Sung‐Yoon Chung Jang Wook Choi 《Liver Transplantation》2018,8(18)
Aqueous rechargeable batteries (ARBs) are gaining increasing attention as alternatives to conventional nonaqueous lithium ion batteries. However, finding electrode materials with competitive electrochemical properties in various aspects is challenging. Moreover, the operation mechanism of some of high performance electrode materials is not fully understood. Here, an α‐phase layered double hydroxide (α‐LDH) working in alkaline electrolytes as an ARB cathode is reported. On charge, OH? carrier ions intercalate into the interlayer space and react with protons detached from the host structure to yield crystal water. This crystal water is then arranged in a superlattice during charging to accommodate carrier ions and stabilize the structure. The solid solution mixing of cobalt and nickel also stabilizes the structure during the wide range of redox swing of Ni from 2+ to 4+. In pairing with Fe3O4/Fe(OH)2 mixture, the α‐LDH exhibits 198.0 mA h g?1 at 3 A g?1, 68.3% capacity retention after 10 000 cycles, and 172.5 mA h g?1 at 1 min charge, demonstrating the promise of hydrated compounds for ARB electrodes. The present study elucidates that the arrangement of crystal water within the host framework plays a critical role in determining the electrochemical performance of the corresponding hydrated active compound in aqueous media. 相似文献
985.
986.
TANK‐binding kinase 1 and Janus kinase 2 play important roles in the regulation of mitogen‐activated protein kinase phosphatase‐1 expression after toll‐like receptor 4 activation 下载免费PDF全文
987.
Sang Hoon Joo Charles W. Pemble Eun Gyeong Yang Christian R.H. Raetz Hak Suk Chung 《Journal of molecular biology》2018,430(21):4036-4048
During lipopolysaccharide biosynthesis in several pathogens, including Burkholderia and Yersinia, 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) 3-hydroxylase, otherwise referred to as KdoO, converts Kdo to d-glycero-d-talo-oct-2-ulosonic acid (Ko) in an Fe(II)/α-ketoglutarate (α-KG)/O2-dependent manner. This conversion renders the bacterial outer membrane more stable and resistant to stresses such as an acidic environment. KdoO is a membrane-associated, deoxy-sugar hydroxylase that does not show significant sequence identity with any known enzymes, and its structural information has not been previously reported. Here, we report the biochemical and structural characterization of KdoO, Minf_1012 (KdoMI), from Methylacidiphilum infernorum V4. The de novo structure of KdoMI apoprotein indicates that KdoOMI consists of 13 α helices and 11 β strands, and has the jelly roll fold containing a metal binding motif, HXDX111H. Structures of KdoMI bound to Co(II), KdoMI bound to α-KG and Fe(III), and KdoMI bound to succinate and Fe(III), in addition to mutagenesis analysis, indicate that His146, His260, and Asp148 play critical roles in Fe(II) binding, while Arg127, Arg162, Arg174, and Trp176 stabilize α-KG. It was also observed that His225 is adjacent to the active site and plays an important role in the catalysis of KdoOMI without affecting substrate binding, possibly being involved in oxygen activation. The crystal structure of KdoOMI is the first completed structure of a deoxy-sugar hydroxylase, and the data presented here have provided mechanistic insights into deoxy-sugar hydroxylase, KdoO, and lipopolysaccharide biosynthesis. 相似文献
988.
Satoshi Kazuma Yasuyuki Tokinaga Yukimasa Takada Ryu Azumaguchi Motonobu Kimizuka Shunsuke Hayashi Michiaki Yamakage 《Biochemical and biophysical research communications》2018,495(1):217-222
The effects of desflurane on endothelium-dependent vasodilation remain uncertain, whereas sevoflurane is known to inhibit it. Endothelium-dependent vasodilation is mainly mediated by endothelial nitric oxide synthase. The effects of desflurane on endothelium-dependent vasodilation were compared with those of sevoflurane, and inhibition mechanisms, including phosphorylation of endothelial nitric oxide synthase and the calcium pathway, were evaluated for the two anesthetics. We hypothesized that desflurane would inhibit endothelium-dependent vasodilation in a concentration-dependent manner more than sevoflurane, with inhibition of a calcium pathway.Isolated rat aortic rings were randomly assigned to treatment with desflurane or sevoflurane for measurements of the vasodilation ratio. To determine NO production with desflurane and sevoflurane, an in vitro assay was performed with cultured bovine aortic endothelial cells. These cells were also used for measurement of intracellular calcium or Western blotting.For endothelium-dependent vasodilation, the ratio of vasodilation was more significantly inhibited by 11.4% desflurane than by 4.8% sevoflurane. Inhibition did not between 5.7% desflurane and 2.4% sevoflurane. No inhibitory effect of desflurane or sevoflurane was observed in endothelium-denuded aorta. Desflurane inhibited nitric oxide production caused by stimulation of bradykinin significantly more than sevoflurane. Desflurane had a greater suppressive effect on the bradykinin-induced increase in intracellular calcium concentration than did sevoflurane. Sevoflurane, but not desflurane, inhibited phosphorylation of the serine 1177 residue by bradykinin stimulation.Desflurane inhibited endothelium-dependent vasodilation more than sevoflurane through inhibition of a calcium pathway. Sevoflurane inhibited endothelium-dependent vasodilation by inhibition of phosphorylation of the serine 1177 residue of endothelial nitric oxide synthase. 相似文献
989.
Huynh Nhu Mai Naveen Sharma Eun-Joo Shin Bao Trong Nguyen Ji Hoon Jeong Choon-Gon Jang Eun-Hee Cho Seung Yeol Nah Nam Hun Kim Toshitaka Nabeshima Hyoung-Chun Kim 《Neurochemical research》2018,43(5):1118-1135
Evidence indicates that stress conditions might lead to drug dependence. Recently, we have demonstrated that exposure to far infrared ray (FIR) attenuates acute restraint stress via induction of glutathione peroxidase-1 (GPx-1) gene. We investigated whether FIR affects methamphetamine (MA)-induced behavioral sensitization and whether FIR-mediated pharmacological activity requires interaction between dopamine receptor and GPx-1 gene. We observed that MA treatment significantly increased GPx-1 expression in the striatum of wild-type (WT) mice. Interestingly, exposure to FIR potentiated MA-induced increase in GPx-1 expression. This phenomenon was also observed in animals receiving MA with dopamine D1 receptor antagonist SCH23390. However, dopamine D2 receptor antagonist sulpiride did not affect MA-induced GPx-1 expression. FIR exposure or SCH23390, but not sulpiride, significantly attenuated MA-induced behavioral sensitization. Exposure to FIR significantly attenuated MA-induced dopamine D1 receptor expression, c-Fos induction and oxidative burdens. FIR-mediated antioxidant effects were also more pronounced in mitochondrial- than cytosolic-fraction. In addition, FIR significantly attenuated against MA-induced changes in mitochondrial superoxide dismutase and mitochondrial GPx activities, mitochondrial transmembrane potential, intramitochondrial Ca2+ level, mitochondrial complex-I activity, and mitochondrial oxidative burdens. The attenuation by FIR was paralleled that by SCH23390. Effects of FIR or SCH23390 were more sensitive to GPx-1 KO than WT mice, while SCH23390 treatment did not exhibit any additive effects on the protective activity mediated by FIR, indicating that dopamine D1 receptor constitutes a molecular target of FIR. Our result suggests that exposure to FIR ameliorates MA-induced behavioral sensitization via possible interaction between dopamine D1 receptor and GPx-1 gene. 相似文献
990.
June Bryan de la Peña Irene Joy dela Peña Raly James Custodio Chrislean Jun Botanas Hee Jin Kim Jae Hoon Cheong 《Molecular neurobiology》2018,55(5):3739-3754
Attention-deficit/hyperactivity disorder (ADHD) is a common, behavioral, and heterogeneous neurodevelopmental condition characterized by hyperactivity, impulsivity, and inattention. Symptoms of this disorder are managed by treatment with methylphenidate, amphetamine, and/or atomoxetine. The cause of ADHD is unknown, but substantial evidence indicates that this disorder has a significant genetic component. Transgenic animals have become an essential tool in uncovering the genetic factors underlying ADHD. Although they cannot accurately reflect the human condition, they can provide insights into the disorder that cannot be obtained from human studies due to various limitations. An ideal animal model of ADHD must have face (similarity in symptoms), predictive (similarity in response to treatment or medications), and construct (similarity in etiology or underlying pathophysiological mechanism) validity. As the exact etiology of ADHD remains unclear, the construct validity of animal models of ADHD would always be limited. The proposed transgenic animal models of ADHD have substantially increased and diversified over the years. In this paper, we compiled and explored the validity of proposed transgenic animal models of ADHD. Each of the reviewed transgenic animal models has strengths and limitations. Some fulfill most of the validity criteria of an animal model of ADHD and have been extensively used, while there are others that require further validation. Nevertheless, these transgenic animal models of ADHD have provided and will continue to provide valuable insights into the genetic underpinnings of this complex disorder. 相似文献