全文获取类型
收费全文 | 92687篇 |
免费 | 6751篇 |
国内免费 | 6447篇 |
专业分类
105885篇 |
出版年
2024年 | 204篇 |
2023年 | 1262篇 |
2022年 | 2955篇 |
2021年 | 4874篇 |
2020年 | 3203篇 |
2019年 | 4031篇 |
2018年 | 3967篇 |
2017年 | 2875篇 |
2016年 | 4060篇 |
2015年 | 5859篇 |
2014年 | 6903篇 |
2013年 | 7270篇 |
2012年 | 8508篇 |
2011年 | 7755篇 |
2010年 | 4493篇 |
2009年 | 4194篇 |
2008年 | 4789篇 |
2007年 | 4158篇 |
2006年 | 3539篇 |
2005年 | 2836篇 |
2004年 | 2316篇 |
2003年 | 2108篇 |
2002年 | 1704篇 |
2001年 | 1473篇 |
2000年 | 1344篇 |
1999年 | 1409篇 |
1998年 | 819篇 |
1997年 | 893篇 |
1996年 | 813篇 |
1995年 | 775篇 |
1994年 | 673篇 |
1993年 | 570篇 |
1992年 | 682篇 |
1991年 | 535篇 |
1990年 | 455篇 |
1989年 | 331篇 |
1988年 | 278篇 |
1987年 | 219篇 |
1986年 | 185篇 |
1985年 | 210篇 |
1984年 | 124篇 |
1983年 | 118篇 |
1982年 | 54篇 |
1981年 | 23篇 |
1980年 | 20篇 |
1979年 | 18篇 |
1976年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Xiao Xiao Bai Peng Cao Shuqiang Jiang Youjing Liang Weibo Wang Tao Luo Xiaolei Guan Qiaozhi Gao Linbo Zhang Lin 《Neurochemical research》2020,45(4):928-939
Neurochemical Research - High-throughput and bioinformatics technology have been broadly applied to demonstrate the key molecules involved in traumatic brain injury (TBI), while no study has... 相似文献
992.
Chen Mi Yang Yang Zhang Wenqi Li Xinning Wu Jinli Zou Xiaohua Zeng Xianggang 《Neurochemical research》2020,45(7):1566-1575
Neurochemical Research - Neuropathic pain is an unneglectable pain condition with limited treatment options owing to its enigmatic underlying mechanisms. Long noncoding RNA small nucleolar RNA host... 相似文献
993.
Qiuxia Cui Jianing Tang Dan Zhang Deguang Kong Xing Liao Jiangbo Ren Yan Gong Conghua Xie Gaosong Wu 《Journal of cellular biochemistry》2020,121(8-9):3923-3934
Breast cancer is a popularly diagnosed malignant tumor. Genomic profiling studies suggest that breast cancer is a disease with heterogeneity. Chemotherapy is one of the chief means to treat breast cancer, while its responses and clinical outcomes vary largely due to the conventional clinicopathological factors and inherent chemosensitivity of breast cancer. Using the least absolute shrinkage and selection operator (LASSO) Cox regression model, our study established a multi-mRNA-based signature model and constructed a relative nomogram in predicting distant-recurrence-free survival for patients receiving surgery and following chemotherapy. We constructed a signature of eight mRNAs (IPCEF1, SYNDIG1, TIGIT, SPESP1, C2CD4A, CLCA2, RLN2, and CCL19) with the LASSO model, which was employed to separate subjects into groups with high- and low-risk scores. Obvious differences of distant-recurrence-free survival were found between these two groups. This eight-mRNA-based signature was independently associated with the prognosis and had better prognostic value than classical clinicopathologic factors according to multivariate Cox regression results. Receiver operating characteristic results demonstrated excellent performance in diagnosing 3-year distant-recurrence by the eight-mRNA signature. A nomogram that combined both the eight-mRNA-based signature and clinicopathological risk factors was constructed. Comparing with an ideal model, the nomograms worked well both in the training and validation sets. Through the results that the eight-mRNA signature effectively classified patients into low- and high-risk of distant recurrence, we concluded that this eight-mRNA-based signature played a promising predictive role in prognosis and could be clinically applied in breast cancer patients receiving adjuvant chemotherapy. 相似文献
994.
Matthew R. Femia Rochelle M. Evans Jibo Zhang Xiaopeng Sun Caroline J. Lebegue Vincent R. Roggero Lizabeth A. Allison 《Journal of cellular biochemistry》2020,121(4):2909-2926
The thyroid hormone receptors (TRs) mediate thyroid hormone (T3)-dependent gene expression. The nuclear import and export signals that direct TR shuttling are well characterized, but little is known about factors modulating nuclear retention. We used fluorescence-based nucleocytoplasmic scoring and fluorescence recovery after photobleaching in transfected cells to investigate whether Mediator subunits MED1 and MED13 play a role in nuclear retention of TR. When MED1 was overexpressed, there was a striking shift towards a greater nuclear localization of TRβ1 and the oncoprotein v-ErbA, subtypes with cytosolic populations at steady-state, and TRβ1 intranuclear mobility was reduced. For TRα1, there was no observable change in its predominantly nuclear distribution pattern or mobility. Consistent with a role for MED1 in nuclear retention, the cytosolic TRα1 and TRβ1 population were significantly greater in MED1−/− cells, compared with MED1+/+ cells. Exposure to T3 and epidermal growth factor, which induces MED1 phosphorylation, also altered TR intranuclear dynamics. Overexpression of miR-208a, which downregulates MED13, led to a more cytosolic distribution of nuclear-localized TRα1; however, overexpression of MED13 had no effect on TRβ1 localization. The known binding site of MED1 overlaps with a transactivation domain and nuclear export signal in helix 12 of TR's ligand-binding domain (LBD). Coimmunoprecipitation assays demonstrated that TR's LBD interacts directly with exportins 5 and 7, suggesting that binding of exportins and MED1 to TR may be mutually exclusive. Collectively, our data provide evidence that MED1 promotes nuclear retention of TR, and highlight the dual functionality of helix 12 in TR transactivation and nuclear export. 相似文献
995.
996.
Xian Zhang Qiuqing Chen Jian Shen Li Wang Yi Cai Kai-Run Zhu 《Journal of cellular biochemistry》2020,121(5-6):3278-3285
The emerging role of microRNAs (miRNAs) have been deeply explored in multiple diseases including neuropathic pain. miR-194 was widely reported to be a tumor suppressor and was related to the inflammatory response. The critical role of neuroinflammation on neuropathic pain leads to a thinking about the relationship between miR-194 and neuropathic pain. However, the function of miR-194 in neuropathic pain remains unknown. This study was aimed to explore the relationship between miR-194 and neuropathic pain progression by chronic sciatic nerve injury (CCI). miR-194 abnormally downregulated in the CCI model rat and its overexpression significantly alleviates neuroinflammation in vivo. We predict Forkhead box protein A1 (FOXA1) as a direct target of miR-194, whose restoration can markedly reverse the effects of miR-194 on neuropathic pain. Overall, our study demonstrated a novel mechanism of neuropathic pain progression that miR-194 alleviates neuropathic pain via targeting FOXA1 and preventing neuroinflammation by downregulating inflammatory cytokines containing cyclooxygenase 2, interleukin 6 (IL-6), and IL-10 in vivo, which can be reversed by the overexpression of FOXA1. 相似文献
997.
998.
999.
Zhao Zhang Zeyan Li Zhao Liu Xiang Zhang Nengwang Yu Zhonghua Xu 《Journal of cellular biochemistry》2020,121(7):3606-3615
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney tumor. Previous studies have shown that the interaction between tumor cells and microenvironment has an important impact on prognosis. Immune and stromal cells are two vital components of the tumor microenvironment. Our study aimed to better understand and explore the genes involved in immune/stromal cells on prognosis. We used the Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data algorithm to calculate immune/stromal scores. According to the scores, we divided ccRCC patients from The Cancer Genome Atlas database into low and high groups and identified the genes which were differentially expressed and significantly associated with prognosis. The result of functional enrichment analysis and protein-protein interaction networks indicated that these genes mainly were involved in extracellular matrix and regulation of cellular activities. Then another independent cohort from the International Cancer Genome Consortium database was used to validate these genes. Finally, we acquired a list of microenvironment-related genes that can predict prognosis for ccRCC patients. 相似文献
1000.
Plant Molecular Biology Reporter - Previously, we cloned the full sequence of masson pine (Pinus massoniana) phosphate transporter gene (PmPT1) from a phosphorus (Pi) deficiency tolerant strain. To... 相似文献