排序方式: 共有372条查询结果,搜索用时 171 毫秒
41.
Nanoporous CaCO3 Coatings Enabled Uniform Zn Stripping/Plating for Long‐Life Zinc Rechargeable Aqueous Batteries
下载免费PDF全文
![点击此处可从《Liver Transplantation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Litao Kang Mangwei Cui Fuyi Jiang Yanfeng Gao Hongjie Luo Jianjun Liu Wei Liang Chunyi Zhi 《Liver Transplantation》2018,8(25)
Zn‐based batteries are safe, low cost, and environmentally friendly, as well as delivering the highest energy density of all aqueous battery systems. However, the application of Zn‐based batteries is being seriously hindered by the uneven electrostripping/electroplating of Zn on the anodes, which always leads to enlarged polarization (capacity fading) or even cell shorting (low cycling stability). How a porous nano‐CaCO3 coating can guide uniform and position‐selected Zn stripping/plating on the nano‐CaCO3‐layer/Zn foil interfaces is reported here. This Zn‐deposition‐guiding ability is mainly ascribed to the porous nature of the nano‐CaCO3‐layer, since similar functionality (even though relatively inferior) is also found in Zn foils coated with porous acetylene black or nano‐SiO2 layers. Furthermore, the potential application of this strategy is demonstrated in Zn|ZnSO4+MnSO4|CNT/MnO2 rechargeable aqueous batteries. Compared with the ones with bare Zn anodes, the battery with a nano‐CaCO3‐coated Zn anode delivers a 42.7% higher discharge capacity (177 vs 124 mAh g?1 at 1 A g?1) after 1000 cycles. 相似文献
42.
The O-antigen gene cluster of Escherichia coli O86:B7 was sequenced previously in our lab. One UDP-hexose 4-epimerase gene (named gne2 in this paper) was found and later characterized to be able to catalyze the interconversion between UDP-GlcNAc/GalNAc and UDP-Glc/Gal with almost equal efficiency. However, sequencing of the flanking gene region upstream of the traditional O-antigen gene cluster revealed an open reading frame (gne1), sharing 100% identity with Gne from E. coli O55, previously identified as UDP-GlcNAc 4-epimerase. Furthermore, we also located the traditional galE gene in the gal operon of O86:B7, which can catalyze the interconversion of UDP-Glc to UDP-Gal. Thus, for the first time, three UDP-hexose 4-epimerases with overlapping substrate specificity were found to coexist in one bacterium. Deletion of gne1 and gne2 in O86:B7 produced two different LPS phenotypes: the gne1 mutant exhibited rough LPS, while the gne2 mutant showed semi-rough LPS phenotype. These findings provide new clues for understanding the mechanism of O-antigen biosynthesis. 相似文献
43.
Huifang Zhou Qichun Zhang Chao Gu Salma Jabeen Jiangye Li Hongjie Di 《Applied microbiology and biotechnology》2017,101(17):6659-6669
The anaerobic ammonium oxidation (anammox) process is globally an important nitrogen-cycling process mediated by specialized microbes. However, still little information is documented about anammox microbial community structure under agricultural soils. The anaerobic incubation experiment was conducted to study the impacts of different land use soils fertilized by 13C-urea on the activity and diversity of anammox bacteria using stable isotope to probe the phospholipid fatty acid (PLFA-SIP). The 13C was preferentially incorporated in ratios PLFAs 16:1ω7c, 16:1ω5c, and 16:0. The results revealed that the abundance of the anammox bacteria (both hzs-β and hzo) were observed in vegetable soil V1 and paddy soils (R1 and R2) means that they were positively correlated with 13C-urea but were negatively correlated with NO3
−-N and NH4
+-N concentrations. Thus, 13C-PLFAs 16:1ω7c, 16:1ω5c, and 16:0 could be the biomarker as soil anammox. The anaerobic microbial community composition of soils under different land use systems was diverse, and V1, R1, and R2 had similar microbial diversity and higher microbial biomass. The principal component analysis between soil properties and gene abundance suggested that not only pH but also soil organic matter, available P, and available K were important factors for the anammox process. This study suggested that 13C-Urea-PLFA for anaerobic incubation was a simple method to study anammox microbial community structure through affecting the soil nutrients, and the different land use systems played important roles in determining the microbial composition of soils. 相似文献
44.
Mona Elbadawi-Sidhu Rebecca A. Baillie Hongjie Zhu Yii-Der Ida Chen Mark O. Goodarzi Jerome I. Rotter Ronald M. Krauss Oliver Fiehn Rima Kaddurah-Daouk 《Metabolomics : Official journal of the Metabolomic Society》2017,13(1):11
Introduction
Statins, widely prescribed drugs for treatment of cardiovascular disease, inhibit the biosynthesis of low density lipoprotein cholesterol (LDL-C). Despite providing major benefits, sub populations of patients experience adverse effects, including muscle myopathy and development of type II diabetes mellitus (T2DM) that may result in premature discontinuation of treatment. There are no reliable biomarkers for predicting clinical side effects in vulnerable individuals. Pharmacometabolomics provides powerful tools for identifying global biochemical changes induced by statin treatment, providing insights about drug mechanism of action, development of side effects and basis of variation of response.Objective
To determine whether statin-induced changes in intermediary metabolism correlated with statin-induced hyperglycemia and insulin resistance; to identify pre-drug treatment metabolites predictive of post-drug treatment increased diabetic risk.Methods
Drug-naïve patients were treated with 40 mg/day simvastatin for 6 weeks in the Cholesterol and Pharmacogenetics (CAP) study; metabolomics by gas chromatography-time-of-flight mass-spectrometry (GC–TOF–MS) was performed on plasma pre and post treatment on 148 of the 944 participants.Results
Six weeks of simvastatin treatment resulted in 6.9% of patients developing hyperglycemia and 25% developing changes consistent with development of pre-diabetes. Altered beta cell function was observed in 53% of patients following simvastatin therapy and insulin resistance was observed in 54% of patients. We identified initial signature of simvastatin-induced insulin resistance, including ethanolamine, hydroxylamine, hydroxycarbamate and isoleucine which, upon further replication and expansion, could be predictive biomarkers of individual susceptibility to simvastatin-induced new onset pre-type II diabetes mellitus. No patients were clinically diagnosed with T2DM.Conclusion
Within this short 6 weeks study, some patients became hyperglycemic and/or insulin resistant. Diabetic markers were associated with decarboxylated small aminated metabolites as well as a branched chain amino acid directly linked to glucose metabolism and fatty acid biosynthesis. Pharmacometabolomics provides powerful tools for precision medicine by predicting development of drug adverse effects in sub populations of patients. Metabolic profiling prior to start of drug therapy may empower physicians with critical information when prescribing medication and determining prognosis.45.
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases 总被引:1,自引:0,他引:1
46.
47.
Chunqiu Ran Fengjie Zhang Hongjie Sun Budiao Zhao 《Biotechnology and Bioprocess Engineering》2009,14(6):835-841
To study the effect of culture medium on hydrogen production by the marine green algae, Platymonas subcordiformis under sulfur deprivation, cell growth, hydrogen production, and starch and protein catabolism was investigated in the work. Algae cells cultured only in optimized medium required 6~8 days to reach the late logarithmic at the approximate density of (2.00 ± 0.18) × 106 cells/mL, which in traditional medium needed 18~22 days to reach (1.85 ± 0.20) × 106 cells/mL. Increased levels of Chlorophyll (10.74 ± 0.20 μg/mL), starch (149.50 ± 6.15 μg/mL), and protein (213.00 ± 7.36 μg/mL) were accumulated in optimized medium, which were 1.06, 1.47, and 1.87-fold of the algae cells cultured in traditional medium, respectively. The sealed culture of algae cells in sulfur-deprived optimized medium shifted to anaerobic conditions after 96 h of light illumination and produced 0.45 ± 0.12 mL H2, but in traditional medium maintained aerobic condition and no hydrogen was produced. In addition, changes in starch and protein content during continuous light illumination indicated that more endogenous substrate was consumed in the sulfur-deprived optimized medium than that in the sulfur-deprived traditional medium. 相似文献
48.
Hongjie Duan Jiake Chai Zhiyong Sheng Yongming Yao Huinan Yin Liming Liang Chuanan Shen Jing Lin 《Apoptosis : an international journal on programmed cell death》2009,14(1):52-65
The purpose of this study was to investigate the occurrence and possible mechanisms of apoptosis in skeletal muscles after
burn injury. After a 40% body surface area burn to rats, TA muscles were examined for apoptosis at varying times by TEM, TUNEL
and cell death ELISA assay. Thermal injury was found to induce apoptosis in skeletal muscle on the first day and maximal apoptosis
appeared 4 days post-injury. Apoptotic ligands in serum assessed by ELISA revealed rapidly increase of TNF-α and subsequent
increase of sFasL to sFas ratio after burn injury. It implied TNF-α induced apoptosis in early stage and FasL induced apoptosis
in later stage after burn injury. Apoptosis-related genes/proteins in skeletal muscles examined by real-time PCR array and
Western blotting showed pro-apoptotic genes/proteins, including Tnfrsf1a, Tnfrsf1b and Tnfsf6 in TNF ligand and receptor family,
Bax and Bid in Bcl-2 family, caspase-3 and caspase-6 in caspase family, Dapk1, FADD and Cidea in death and CIDE domain family,
Apaf-1 in CARD family, and Gadd45a were up-regulated, while anti-apoptotic gene Bnip1 was down-regulated compared with that
of time-matched controls. In addition, increment of caspase-3, caspase-8 and caspase-9 activity provided further evidence
for their role in apoptosis in skeletal muscle. Significant increase in expression in pro-apoptotic genes/proteins and activity
of caspases suggested that death receptor-mediated signaling pathways and other apoptotic related pathways participated in
apoptosis in skeletal muscle after burn injury. However, it was found that some anti-apoptotic genes such as Bcl2l1, Mcl-1,
Nol-3, Il-10 and Prok2 were also up-regulated, which might imply the co-existence of protective response of the body after
burns. In conclusion, the data suggest that apoptosis and pro-apoptotic signaling are enhanced in muscles of burned rats.
To further elucidate the underlying apoptotic mechanisms mediating the atrophic response is important in establishing potential
therapeutic interventions that could prevent and/or reduce skeletal muscle wasting and preserve its physiological function. 相似文献
49.
Lingyun Zhu Guoxun Sun Hongjie Zhang Yan Zhang Xi Chen Xiaohong Jiang Xueyuan Jiang Stefan Krauss Junfeng Zhang Yang Xiang Chen-Yu Zhang 《PloS one》2009,4(1)
Background
Atherosclerosis is a complex pathological condition caused by a number of mechanisms including the accelerated proliferation of vascular smooth muscle cells (VSMCs). Diabetes is likely to be an important risk factor for atherosclerosis, as hyperglycemia induces vascular smooth muscle cell (VSMC) proliferation and migration and may thus contribute to the formation of atherosclerotic lesions. This study was performed to investigate whether PGC-1α, a PPARγ coactivator and metabolic master regulator, plays a role in regulating VSMC proliferation and migration induced by high glucose.Methodology/Principal Findings
PGC-1α mRNA levels are decreased in blood vessel media of STZ-treated diabetic rats. In cultured rat VSMCs, high glucose dose-dependently inhibits PGC-1α mRNA expression. Overexpression of PGC-1α either by infection with adenovirus, or by stimulation with palmitic acid, significantly reduces high glucose-induced VSMC proliferation and migration. In contrast, suppression of PGC-1α by siRNA mimics the effects of glucose on VSMCs. Finally, mechanistic studies suggest that PGC-1α-mediated inhibition of VSMC proliferation and migration is regulated through preventing ERK1/2 phosphorylation.Conclusions/Significance
These results indicate that PGC-1α is a key regulator of high glucose-induced proliferation and migration in VSMCs, and suggest that elevation of PGC-1α in VSMC could be a useful strategy in preventing the development of diabetic atherosclerosis. 相似文献50.
Vitamin E is important for human and animal health. Many human diseases, such as certain cancers and neurodegenerative and cardiovascular disease, are associated with the insufficient intake of vitamin E. The daily requirements for vitamin E in men and women have been increased to 15–30 mg. Because the primary source of dietary vitamin E comes from plants, there is a need to increase vitamin E production through plant engineering in order to meet the demand in human consumption. Numerous studies have been carried out in this field, leading to many successful examples. In this review, we summarized the recent progress in vitamin E metabolic engineering in plants aimed at improving the vitamin E content and regulating composition of vitamin E. 相似文献