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221.
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Karim Aghcheli Haji-Amin Marjani Dariush Nasrollahzadeh Farhad Islami Ramin Shakeri Masoud Sotoudeh Behnoush Abedi-Ardekani Mohammad-Reza Ghavamnasiri Ezzatollah Razaei Elias Khalilipour Samira Mohtashami Yasha Makhdoomi Rabea Rajabzadeh Shahin Merat Rasoul Sotoudehmanesh Shahryar Semnani Reza Malekzadeh 《PloS one》2011,6(7)
223.
Sousan Mousavi Roya Moallem Seyed Mahdi Hassanian Mahsa Sadeghzade Ramin Mardani Gordon A. Ferns Majid Khazaei Amir Avan 《Journal of cellular physiology》2019,234(8):12422-12432
Colorectal cancer (CRC) is the third most common cause of cancer-related death in men and women in many countries. Early detection of CRC helps to prevent the advanced stages of the disease, and may thereby improve the survival of these patients. A noninvasive test with high specificity and sensitivity is required for this. Exosomes are lipid bilayer membrane nanovesicles that are released into most body fluids and especially in the microenvironment of cancer. They carry various proteins, lipids, and nucleic materials such as DNA, RNA, messenger RNA (mRNA), and microRNA (miRNA), and may also alter the function of target cells. In this review, we aimed to describe the biogenesis, composition, function, and the role of tumor-derived exosomes in cancer progression. Moreover, their applications in tumor diagnosis and treatment are described, with a particular focus on CRC. 相似文献
224.
Dystrophin Dp71 is expressed in all tissues, with the exception of skeletal muscle, and is the main Duchenne muscular dystrophy
(DMD) gene product in brain. As full-length dystrophin does in skeletal muscle, Dp71 associates with dystroglycans, sarcoglycans,
dystrobrevins, syntrophins, and accessory proteins to form the dystrophin-associated protein complex (DAPC) in non-muscle
tissues. Although it has been nearly 20 years since the discovery of Dp71, its study has become relevant only recently due
to its direct involvement with the two main DMD non-muscular phenotypes: cognitive impairment and abnormal retinal physiology.
In this review, we describe the historical background of Dp71 and the experimental models developed for its study. Additionally,
we present and discuss the experimental evidence supporting the participation of Dp71 in different cellular processes, including
cell adhesion, water homeostasis, cell division, and nuclear architecture. The functional diversity of Dp71 is attributed
to the formation of Dp71-containing DAPC in numerous cell types and different subcellular compartments, including in plasma
membrane and nucleus, as well as to the capability of Dp71-containing DAPC to work as the scaffold for proper clustering and
anchoring of structural and signaling proteins to the plasma membrane and of nuclear envelope proteins to the inner nuclear
membrane. 相似文献
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Karimi MH Daneshmandi S Pourfathollah AA Geramizadeh B Malekhosseini SA Nikeghbalian S Yaghobi R Bolandparvaz S 《Molecular biology reports》2011,38(7):4437-4443
Liver transplantation is one of the most important therapies for end-stage liver diseases and is associated with major problems
including infections and acute rejection. The outcome of transplantation can be determined by immune responses as a key role
in response to the graft. Inflammatory and anti-inflammatory mediators especially cytokines influence the graft microenvironment.
Th1 and Th2 immune responses in contrast to regulatory responses cause acute rejection or help graft survival. In this study,
we evaluated the gene polymorphisms of IL-6 G-174C, TGF-β T + 869C, IL-4 C-590T, and IFN-γ T + 874A cytokines in liver transplant patients. ARMS-PCR method was used to characterize IL-6 G-174C, TGF-β T + 869C and IFN-γ T + 874A polymorphisms and PCR-RFLP using AvaII restriction enzyme was done for IL-4 C-590T characterization in 70 liver transplant patients. Acute rejection episodes were diagnosed according to standard criteria.
The analysis of the results showed that IL-6-174 GG genotype (
P = 0.009, OR = 4.333, 95% CI = 1.043–18.000), IL-6-174G allele (P = 0.011, OR = 5.273, 95% CI = 1.454–19.127) was more frequent and IFN-γ +874 TT genotype was less frequent (P = 0.043, OR = 0.143, 95% CI = 0.0118–1.190) in acute rejection than in non-rejection patients. TGF-β T + 869C and IL-4 C-590T
frequencies were not significantly different (P > 0.05). According to the results, it can be conclude that IL-6 G-174C and IFN-γ T + 874A gene polymorphisms have predictive values for acute rejection after liver transplantation. High producer genotype of IL-6
is a genetic risk factor and IFN-γ is a protective factor for acute rejection development. 相似文献
230.
Shiau TP Turtle ED Francavilla C Alvarez NJ Zuck M Friedman L O'Mahony DJ Low E Anderson MB Najafi RR Jain RK 《Bioorganic & medicinal chemistry letters》2011,21(10):3025-3028
Antimicrobial resistance against many known therapeutics is on the rise. We examined derivatives of 3-chlorooxazolidin-2-one 1a (X = H) as antibacterial and antifungal agents. The key findings were that the activity and apparent in vitro cytotoxicity could be controlled by the substitution of charged solubilizers at the 4- and 5- positions. These changes both significantly increase the antifungal potency and decrease cytotoxicity. Particularly effective were trialkylammonium groups which led to 400- to 600-fold increases in the antifungal therapeutic index when compared to their unsubstituted counterparts. 相似文献