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51.
Wolf C Kusch H Monecke S Albrecht D Holtfreter S von Eiff C Petzl W Rainard P Bröker BM Engelmann S 《Proteomics》2011,11(12):2491-2502
Staphylococcus aureus colonizes and infects humans as well as animals. In the present study, 17 S. aureus strains isolated from cows suffering from mastitis were characterized. The well-established multilocus sequence typing (MLST) technique and a diagnostic microarray covering 185 S. aureus virulence and resistance genes were used for genetic and epidemiological analyses. Virulence gene expression studies were performed by analyzing the extracellular protein pattern of each isolate on 2-D gels. By this way, a pronounced heterogeneity of the extracellular proteome between the bovine isolates has been observed which was attributed to genome plasticity and variation of gene expression. Merely 12 proteins were expressed in at least 80% of the isolates, i.e. Atl, Aur, GlpQ, Hla, LtaS, Nuc, PdhB, SAB0846, SAB2176, SAB0566, SspA, and SspB forming the core exoproteome. Fifteen extracellular proteins were highly variably expressed and only present in less than 20% of the isolates. This includes the serine proteases SplB, C, and F, and the superantigens SEC-bov, SEL and TSST-1. Compared to human isolates we identified at least six proteins with significantly different expression frequencies. While SAB0846 was expressed more frequently in bovine isolates, LytM, EbpS, Spa, Geh, and LukL1 were seen less frequently in these isolates. 相似文献
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54.
J. Holtfreter 《Development genes and evolution》1938,138(3-4):522-656
Ohne ZusammenfassungAusgeführt mit Hilfe einer Unterstützung durch die Deutsche Forschungsgemeinschaft. 相似文献
55.
J. Holtfreter 《Development genes and evolution》1936,134(3):466-550
Ohne Zusammenfassung 相似文献
56.
Johannes Holtfreter 《Development genes and evolution》1935,133(3):367-426
Ohne Zusammenfassung 相似文献
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The respiratory sensation and some routine cardiorespiratory parameters were studied on native Highlanders from the Argentine
Andes and on Lowlanders from Europe, already tested during previous high altitude expeditions. The tests were performed at
various altitude levels from 2688m e.i., the village altitude for Highlanders, to 5600m during an expedition to Mt. Aconcagua
(6990m). At rest, the perception of 4 external inspiratory resistive loads (ranged between 2.5 and 13 cm.H2O.L-1.s) can allow
us to fix by discrimination the sensitivity index P(A) independently of response bias (B) according to Sensory Decision Theory
(SDT). The Andean highlanders did not experience the respiratory sensation at the same limits as the European lowlanders well
adaptated to high altitude. At higher altitudes than their village altitude, their respiratory sensation presented a lower
threshold of perception and a weaker discrimination which might be partly explained by the evolution of some parameters of
their cardio-respiratory function when altitude increased. Indeed, in response to high altitude hypoxia (5600m), they increased
their respiratory frequency and not their minuteventilation or mouth pressure. This chosen ventilatory pattern was opposite
to the one chosen by the Lowlanders and did not allow for sufficient adaptation to a more important altitude hypoxia than
that of their village altitude. In conclusion, the Andean highlanders wellbeing adapted to their village altitude, exhibited
a difficult acclimatization to higher altitudes which might be due to the characteristics of their respiratory sensation.
These results might explain their weak physical performances during ascent to the Mt. Aconcagua summit in spite of special
training. 相似文献
60.
M.C. Holtfreter M. Loebermann S. Klammt M. Sombetzki P. Bodammer D. Riebold R. Kinzelbach E.C. Reisinger 《Experimental parasitology》2011,127(1):270-276
We investigated the effects of the anti-malarials mefloquine and primaquine against the juvenile and adult life stages of Schistosoma mansoniin vitro. Cercariae were incubated with 0.5 μg/ml, 1 μg/ml and 2 μg/ml mefloquine or primaquine and with 1 μg/ml praziquantel for 12 h. Schistosomula, pre-adults and adults were incubated with 0.5 μg/ml, 1 μg/ml and 2 μg/ml mefloquine or primaquine and with 1 μg/ml praziquantel for 7 days. The viability status was classified as viable, damaged or dead and was checked every 3 h for cercariae and every 12 h for schistosomula, pre-adults and adults. Both, mefloquine and primaquine show time and dose-dependent schistosomicidal effects on the four life stages of S. mansoni. The promising in vitro effects on all stages of the blood fluke S. mansoni warrants further evaluation of both anti-malarials and their derivatives for their prophylactic and therapeutic values in early and late schistosomiasis in field trials. 相似文献