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641.
Background
The impressive increase of novel RNA structures, during the past few years, demands automated methods for structure comparison. While many algorithms handle only small motifs, few techniques, developed in recent years, (ARTS, DIAL, SARA, SARSA, and LaJolla) are available for the structural comparison of large and intact RNA molecules. 相似文献642.
Shawn J. Stachel Craig A. Coburn Diane Rush Kristen L.G. Jones Hong Zhu Hemaka Rajapakse Samuel L. Graham Adam Simon M. Katharine Holloway Tim J. Allison Sanjeev K. Munshi Amy S. Espeseth Paul Zuck Dennis Colussi Abigail Wolfe Beth L. Pietrak Ming-Tain Lai Joseph P. Vacca 《Bioorganic & medicinal chemistry letters》2009,19(11):2977-2980
We have developed a novel series of heteroaromatic BACE-1 inhibitors. These inhibitors interact with the enzyme in a unique fashion that allows for potent binding in a non-traditional paradigm. In addition to the elucidation of their binding profile, we have discovered a pH dependent effect on the binding affinity as a result of the intrinsic pKa of these inhibitors and the pH of the BACE-1 enzyme binding assay. 相似文献
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Brazma A Parkinson H Sarkans U Shojatalab M Vilo J Abeygunawardena N Holloway E Kapushesky M Kemmeren P Lara GG Oezcimen A Rocca-Serra P Sansone SA 《Nucleic acids research》2003,31(1):68-71
ArrayExpress is a new public database of microarray gene expression data at the EBI, which is a generic gene expression database designed to hold data from all microarray platforms. ArrayExpress uses the annotation standard Minimum Information About a Microarray Experiment (MIAME) and the associated XML data exchange format Microarray Gene Expression Markup Language (MAGE-ML) and it is designed to store well annotated data in a structured way. The ArrayExpress infrastructure consists of the database itself, data submissions in MAGE-ML format or via an online submission tool MIAMExpress, online database query interface, and the Expression Profiler online analysis tool. ArrayExpress accepts three types of submission, arrays, experiments and protocols, each of these is assigned an accession number. Help on data submission and annotation is provided by the curation team. The database can be queried on parameters such as author, laboratory, organism, experiment or array types. With an increasing number of organisations adopting MAGE-ML standard, the volume of submissions to ArrayExpress is increasing rapidly. The database can be accessed at http://www.ebi.ac.uk/arrayexpress. 相似文献
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A bacterial mutation, risA, in Pseudomonas aeruginosa caused growth inhibition at 43 degrees C of risA strains containing P2 plasmids. Incubation at 43 degrees C resulted in selection for clones that had lost P2 plasmids. 相似文献
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W. G. Holloway 《BMJ (Clinical research ed.)》1903,1(2199):466-467
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Isolation of α-tubulin genes from the human malaria parasite, Plasmodium falciparum: sequence analysis of α-tubulin 总被引:1,自引:1,他引:0
S. P. Holloway P. F. G. Sims C. J. Delves J. G. Scaife J. E. Hyde 《Molecular microbiology》1989,3(11):1501-1510
As a step towards identifying exploitable differences between host and parasite at the molecular level, we have isolated and sequenced genomic clones encompassing an entire alpha-tubulin gene (designated alpha-tubulin I) from the human malaria parasite, Plasmodium falciparum. The gene, which contains two introns, encodes a product with a predicted length of 453 amino acid residues (50.3 kD). The protein sequence shows a high degree of homology to other alpha-tubulins, particularly that of the coccidian parasite, Toxoplasma gondii (94%), whose gene carries introns in identical positions. Only one copy of the alpha-tubulin I gene itself was found, although a second gene designated alpha-II was also identified which is closely related but which differs at both the nucleotide and amino acid sequence levels. The alpha-I and beta-tubulin genes were found to reside on different chromosomes. 相似文献
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Sara E. Howden Sean B. Wilson Ella Groenewegen Lakshi Starks Thomas A. Forbes Ker Sin Tan Jessica M. Vanslambrouck Emily M. Holloway Yi-Hsien Chen Sanjay Jain Jason R. Spence Melissa H. Little 《Cell Stem Cell》2021,28(4):671-684.e6
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